Reference - PMID:17369398 - A novel checkpoint mechanism regulating the G1/S transition.
Reference summary
- PubMed ID
- PMID:17369398
- Title
- A novel checkpoint mechanism regulating the G1/S transition.
- Authors
- Tvegård T, Soltani H, Skjølberg HC, Krohn M, Nilssen EA, Kearsey SE, Grallert B, Boye E
- Citation
- Genes Dev 2007 Mar 15;21(6):649-54
- Publication year
- 2007
- Abstract
- Ultraviolet irradiation of fission yeast cells in G1 phase induced a delay in chromatin binding of replication initiation factors and, consistently, a transient delay in S-phase entry. The cell cycle delay was totally dependent on the Gcn2 kinase, a sensor of the nutritional status, and was accompanied by phosphorylation of the translation initiation factor eIF2alpha and by a general depression of translation. However, the G1-specific synthesis of factors required for DNA replication was not reduced by ultraviolet radiation. The cell cycle delay represents a novel checkpoint with a novel mechanism of action that is not activated by ionizing radiation.
