Reference - PMID:17898859 - Overexpression of a metacaspase gene stimulates cell growth and stress response in Schizosaccharomyces pombe.

Reference summary

PubMed ID

PMID:17898859

Title

Overexpression of a metacaspase gene stimulates cell growth and stress response in Schizosaccharomyces pombe.

Authors

Lim HW, Kim SJ, Park EH, Lim CJ

Citation

Can J Microbiol 2007 Aug;53(8):1016-23

Publication year

2007

Abstract

A unique gene named pca1(+), encoding a metacaspase, was cloned from the fission yeast Schizosaccharomyces pombe and was used to create a recombinant plasmid, pPMC. The metacaspase mRNA level was markedly elevated in the fission yeast cells harboring the plasmid pPMC. Overexpressed Pca1(+) appeared to stimulate the growth of the fission yeast cells instead of arresting their growth. Its expression was enhanced by stress-inducing agents such as H(2)O(2), sodium nitroprusside, and CdCl(2), and it conferred cytoprotection, especially against CdCl(2). However, such protection was not reproducible in the budding yeast Saccharomyces cerevisiae harboring pPMC. Taken together, these results propose that Pca1(+) may be involved in the growth and stress response of the fission yeast.

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