Reference - PMID:17998401 - Nuclear size control in fission yeast.
Reference summary
- PubMed ID
- PMID:17998401
- Title
- Nuclear size control in fission yeast.
- Authors
- Neumann FR, Nurse P
- Citation
- J Cell Biol 2007 Nov 19;179(4):593-600
- Publication year
- 2007
- Abstract
- A long-standing biological question is how a eukaryotic cell controls the size of its nucleus. We report here that in fission yeast, nuclear size is proportional to cell size over a 35-fold range, and use mutants to show that a 16-fold change in nuclear DNA content does not influence the relative size of the nucleus. Multi-nucleated cells with unevenly distributed nuclei reveal that nuclei surrounded by a greater volume of cytoplasm grow more rapidly. During interphase of the cell cycle nuclear growth is proportional to cell growth, and during mitosis there is a rapid expansion of the nuclear envelope. When the nuclear/cell (N/C) volume ratio is increased by centrifugation or genetic manipulation, nuclear growth is arrested while the cell continues to grow; in contrast, low N/C ratios are rapidly corrected by nuclear growth. We propose that there is a general cellular control linking nuclear growth to cell size.
