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Reference - PMID:18438419 - The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

Reference summary

PubMed ID
PMID:18438419
Title
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
Authors
Gabel HW, Ruvkun G
Citation
Nat Struct Mol Biol 2008 May;15(5):531-3
Publication year
2008
Abstract
The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.

Annotation

GO biological process

GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Genes:

GO molecular function

GO:0000175 - 3'-5'-RNA exonuclease activity

Genes:

Single locus phenotype

FYPO:0006298 - abnormal 5.8S rRNA 3'-end processing

Genes:

Genotypes:

FYPO:0006297 - increased 5.8S rRNA length

Genes:

Genotypes: