Reference - PMID:18535244 - Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.
Reference summary
- PubMed ID
- PMID:18535244
- Title
- Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.
- Authors
- Miyoshi T, Kanoh J, Saito M, Ishikawa F
- Citation
- Science 2008 Jun 06;320(5881):1341-4
- Publication year
- 2008
- Abstract
- Telomeres are specialized chromatin structures that protect chromosomal ends. Protection of telomeres 1 (Pot1) binds to the telomeric G-rich overhang, thereby protecting telomeres and regulating telomerase. Mammalian POT1 and TPP1 interact and constitute part of the six-protein shelterin complex. Here we report that Tpz1, the TPP1 homolog in fission yeast, forms a complex with Pot1. Tpz1 binds to Ccq1 and the previously undiscovered protein Poz1 (Pot1-associated in Schizosaccharomyces pombe), which protect telomeres redundantly and regulate telomerase in positive and negative manners, respectively. Thus, the Pot1-Tpz1 complex accomplishes its functions by recruiting effector molecules Ccq1 and Poz1. Moreover, Poz1 bridges Pot1-Tpz1 and Taz1-Rap1, thereby connecting the single-stranded and double-stranded telomeric DNA regions. Such molecular architectures are similar to those of mammalian shelterin, indicating that the overall DNA-protein architecture is conserved across evolution.
Orthologs
- ACD (HGNC:25070) Homo sapiens
