Reference - PMID:20699567 - Vacuolar amino acid transporter Avt5p is responsible for lithium uptake in Schizosaccharomyces pombe.
Reference summary
- PubMed ID
- PMID:20699567
- Title
- Vacuolar amino acid transporter Avt5p is responsible for lithium uptake in Schizosaccharomyces pombe.
- Authors
- Iwaki T, Sekito T, Kakinuma Y
- Citation
- Biosci Biotechnol Biochem 2010;74(8):1719-21
- Publication year
- 2010
- Abstract
- The fission yeast Schizosaccharomyces pombe was sensitive to salinity; cell growth was stopped by 0.5 M NaCl and by 10 mM LiCl. The avt5+ gene encodes a vacuolar transporter with a broad specificity for amino acids. We found that the avt5Delta mutant became highly tolerant of Li+ and Na+ in growth. Concanamycin A-sensitive Li+ uptake as well as cellular Li+ content was lower in the avt5 mutant, suggesting a role of Avt5p in cellular uptake of toxic Li+.
