Reference - PMID:21307582 - Atg22p, a vacuolar membrane protein involved in the amino acid compartmentalization of Schizosaccharomyces pombe.

Reference summary

PubMed ID

PMID:21307582

Title

Atg22p, a vacuolar membrane protein involved in the amino acid compartmentalization of Schizosaccharomyces pombe.

Authors

Sugimoto N, Iwaki T, Chardwiriyapreecha S, Shimazu M, Kawano M, Sekito T, Takegawa K, Kakinuma Y

Citation

Biosci Biotechnol Biochem 2011;75(2):385-7

Publication year

2011

Abstract

The fission yeast Schizosaccharomyces pombe has a homolog of the budding yeast Atg22p, which is involved in spore formation (Mukaiyama H. et al., Microbiology, 155, 3816-3826 (2009)). GFP-tagged Atg22p in the fission yeast was localized to the vacuolar membrane. Upon disruption of atg22, the amino acid levels of the cellular fraction as well as the vacuolar fraction decreased. The uptake of several amino acids, such as lysine, histidine, and arginine, was impaired in atg22Δ cells. S. pombe Atg22p plays an important role in the compartmentalization of amino acids.

Annotation