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Reference - PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Reference summary

PubMed ID
PMID:23697806
Title
A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Authors
Hayles J, Wood V, Jeffery L, Hoe KL, Kim DU, Park HO, Salas-Pino S, Heichinger C, Nurse P
Citation
Open Biol 2013 May 22;3(5):130053
Publication year
2013
Abstract
To identify near complete sets of genes required for the cell cycle and cell shape, we have visually screened a genome-wide gene deletion library of 4843 fission yeast deletion mutants (95.7% of total protein encoding genes) for their effects on these processes. A total of 513 genes have been identified as being required for cell cycle progression, 276 of which have not been previously described as cell cycle genes. Deletions of a further 333 genes lead to specific alterations in cell shape and another 524 genes result in generally misshapen cells. Here, we provide the first eukaryotic resource of gene deletions, which describes a near genome-wide set of genes required for the cell cycle and cell shape.

Annotation

Single locus phenotype

FYPO:0000190 - abnormal actin cortical patch localization during vegetative growth

Genes:

Genotypes:

FYPO:0002398 - abnormal actin cytoskeleton during vegetative growth

Genes:

Genotypes:

FYPO:0000350 - abnormal actin cytoskeleton morphology during vegetative growth

Genes:

Genotypes:

FYPO:0000164 - abnormal cell separation after cytokinesis

Genes:

Genotypes:

FYPO:0001971 - abnormal cell separation after cytokinesis resulting in chained cells

Genes:

Genotypes:

FYPO:0002399 - abnormal microtubule cytoskeleton

Genes:

Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

Genes:

Genotypes:

FYPO:0000117 - abnormal septum assembly

Genes:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

Genes:

Genotypes:

FYPO:0001018 - abolished NETO

Genes:

Genotypes:

FYPO:0001512 - branched, elongated cell

Genes:

Genotypes:

FYPO:0002296 - cone-shaped colony morphology

Genes:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

Genes:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

Genes:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

Genes:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

Genes:

Genotypes:

FYPO:0001122 - elongated vegetative cell

Genes:

Genotypes:

FYPO:0000741 - increased cellular pigment accumulation

Genes:

Genotypes:

FYPO:0000650 - increased septation index

Genes:

Genotypes:

FYPO:0000252 - increased spontaneous diploidization

Genes:

Genotypes:

FYPO:0002281 - inviable after spore germination with abnormal germ tube morphology

Genes:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

Genes:

Genotypes:

FYPO:0002294 - inviable after spore germination with elongated germ tube and cell lysis

Genes:

Genotypes:

FYPO:0000312 - inviable after spore germination with normal, septated germ tube morphology

Genes:

Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

Genes:

Genotypes:

FYPO:0002429 - inviable after spore germination, multiple cell divisions, abnormal cell shape, normal cell size

Genes:

Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

Genes:

Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

Genes:

Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

Genes:

Genotypes:

FYPO:0001110 - inviable after spore germination, multiple cell divisions, normal morphology

Genes:

Genotypes:

FYPO:0002280 - inviable after spore germination, single cell division

Genes:

Genotypes:

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

Genes:

Genotypes:

FYPO:0000320 - inviable after spore germination, single cell division, normal cell morphology

Genes:

Genotypes:

FYPO:0002409 - inviable after spore germination, single cell division, with elongated germ tube

Genes:

Genotypes:

FYPO:0002279 - inviable after spore germination, single cell division, with elongated, curved germ tube

Genes:

Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

Genes:

Genotypes:

FYPO:0002421 - inviable after spore germination, single or double cell division, abnormal cell shape

Genes:

Genotypes:

FYPO:0002724 - inviable after spore germination, single or double cell division, elongated cell

Genes:

Genotypes:

FYPO:0001991 - inviable after spore germination, without cell division

Genes:

Genotypes:

FYPO:0002423 - inviable after spore germination, without cell division, septated cells with abnormal cell shape

Genes:

Genotypes:

FYPO:0002987 - inviable after spore germination, without cell division, swollen binucleate cell with central constriction

Genes:

Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

Genes:

Genotypes:

FYPO:0002515 - inviable after spore germination, without cell division, with branched, elongated germ tube

Genes:

Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

Genes:

Genotypes:

FYPO:0002212 - inviable after spore germination, without cell division, with elongated, curved germ tube

Genes:

Genotypes:

FYPO:0000315 - inviable after spore germination, without cell division, with elongated, septated germ tube

Genes:

Genotypes:

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

Genes:

Genotypes:

FYPO:0002911 - inviable after spore germination, without cell division, with swollen elongated germ tube

Genes:

Genotypes:

FYPO:0003005 - inviable after spore germination, without cell division, with swollen, branched, elongated germ tube

Genes:

Genotypes:

FYPO:0002463 - inviable branched, curved, elongated vegetative cell

Genes:

Genotypes:

FYPO:0002462 - inviable branched, elongated vegetative cell

Genes:

Genotypes:

FYPO:0002411 - inviable curved elongated vegetative cell

Genes:

Genotypes:

FYPO:0002282 - inviable curved septated vegetative cell

Genes:

Genotypes:

FYPO:0002250 - inviable curved vacuolated vegetative cell

Genes:

Genotypes:

FYPO:0002113 - inviable curved vegetative cell

Genes:

Genotypes:

FYPO:0002242 - inviable elongated tapered vegetative cell

Genes:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

Genes:

Genotypes:

FYPO:0002193 - inviable normal volume septated spheroid vegetative cell

Genes:

Genotypes:

FYPO:0002187 - inviable normal volume spheroid vegetative cell

Genes:

Genotypes:

FYPO:0002483 - inviable small tapered vegetative cell

Genes:

Genotypes:

FYPO:0000951 - inviable small vegetative cell

Genes:

Genotypes:

FYPO:0002482 - inviable spheroid vegetative cell

Genes:

Genotypes:

FYPO:0002151 - inviable spore

Genes:

Genotypes:

FYPO:0002427 - inviable spore with abnormal shape

Genes:

Genotypes:

FYPO:0002200 - inviable stubby septated vegetative cell

Genes:

Genotypes:

FYPO:0002107 - inviable stubby vegetative cell

Genes:

Genotypes:

FYPO:0002230 - inviable swollen curved vegetative cell

Genes:

Genotypes:

FYPO:0002083 - inviable swollen elongated cell with enlarged nucleus

Genes:

Genotypes:

FYPO:0002251 - inviable swollen elongated vegetative cell

Genes:

Genotypes:

FYPO:0002207 - inviable swollen spore

Genes:

Genotypes:

FYPO:0002415 - inviable swollen vegetative cell with abnormal cell shape

Genes:

Genotypes:

FYPO:0002109 - inviable tapered cell

Genes:

Genotypes:

FYPO:0002111 - inviable tapered vegetative cell

Genes:

Genotypes:

FYPO:0002410 - inviable vacuolated vegetative cell, abnormal cell shape, normal cell size

Genes:

Genotypes:

FYPO:0001489 - inviable vegetative cell

Genes:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

Genes:

Genotypes:

FYPO:0002273 - inviable vegetative cell with abnormal cell morphology

Genes:

Genotypes:

FYPO:0002451 - inviable vegetative cell with abnormal cell shape

Genes:

Genotypes:

FYPO:0002199 - inviable vegetative cell with normal cell morphology

Genes:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

Genes:

Genotypes:

FYPO:0001404 - irregular colony morphology

Genes:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

Genes:

Genotypes:

FYPO:0001864 - mating without glucose starvation

Genes:

Genotypes:

FYPO:0001886 - meiotic cell cycle entry and sporulation in haploid

Genes:

Genotypes:

FYPO:0002401 - microtubule bundles present in increased numbers

Genes:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

Genes:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

Genes:

Genotypes:

FYPO:0002115 - normal transmembrane transporter activity

Genes:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

Genes:

Genotypes:

FYPO:0000946 - normal volume spheroid vegetative cell

Genes:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

Genes:

Genotypes:

FYPO:0002400 - single microtubule bundle during mitotic interphase

Genes:

Genotypes:

FYPO:0000021 - spheroid vegetative cell

Genes:

Genotypes:

FYPO:0002489 - spore lysis

Genes:

Genotypes:

FYPO:0002240 - swollen septated spheroid vegetative cell

Genes:

Genotypes:

FYPO:0000013 - T-shaped vegetative cell with normal cell length

Genes:

Genotypes:

FYPO:0000647 - vegetative cell lysis

Genes:

Genotypes:

FYPO:0002480 - viable after spore germination with elongated germ tube

Genes:

Genotypes:

FYPO:0002460 - viable branched, curved, elongated vegetative cell

Genes:

Genotypes:

FYPO:0002459 - viable branched, elongated vegetative cell

Genes:

Genotypes:

FYPO:0002215 - viable curved elongated vegetative cell

Genes:

Genotypes:

FYPO:0002457 - viable curved elongated vegetative cell with abnormal septum

Genes:

Genotypes:

FYPO:0002406 - viable curved stubby septated vegetative cell

Genes:

Genotypes:

FYPO:0002405 - viable curved stubby vegetative cell

Genes:

Genotypes:

FYPO:0002478 - viable curved vacuolated vegetative cell

Genes:

Genotypes:

FYPO:0002112 - viable curved vegetative cell

Genes:

Genotypes:

FYPO:0002456 - viable curved vegetative cell with abnormal septum

Genes:

Genotypes:

FYPO:0001496 - viable elongated multiseptate vegetative cell

Genes:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

Genes:

Genotypes:

FYPO:0000648 - viable small vegetative cell

Genes:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

Genes:

Genotypes:

FYPO:0002380 - viable spheroid vegetative cell

Genes:

Genotypes:

FYPO:0002106 - viable stubby vegetative cell

Genes:

Genotypes:

FYPO:0002402 - viable swollen vegetative cell with abnormal cell shape

Genes:

Genotypes:

FYPO:0002110 - viable tapered vegetative cell

Genes:

Genotypes:

FYPO:0002476 - viable vacuolated vegetative cell, abnormal cell shape, normal cell size

Genes:

Genotypes:

FYPO:0002060 - viable vegetative cell population

Genes:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

Genes:

Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

Genes:

Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

Genes:

Genotypes: