Reference - PMID:24530531 - Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips.
Reference summary
- PubMed ID
- PMID:24530531
- Title
- Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips.
- Authors
- Zheng F, Li T, Cheung M, Syrovatkina V, Fu C
- Citation
- FEBS Lett 2014 Mar 18;588(6):859-65
- Publication year
- 2014
- Abstract
- Microtubule plus ends are dynamically regulated by a wide variety of proteins for performing diverse cellular functions. Here, we show that the fission yeast Schizosaccharomyces pombe uncharacterized protein mcp1p is a microtubule plus-end tracking protein which depends on the kinesin-8 klp6p for transporting along microtubules towards microtubule plus ends. In the absence of mcp1p, microtubule catastrophe and rescue frequencies decrease, leading to an increased dwell time of microtubule plus ends at cell tips. Thus, these findings suggest that mcp1p may synergize with klp6p at microtubule plus-ends to destabilize microtubules.
