Reference - PMID:25763975 - Kinesin-8 motors improve nuclear centering by promoting microtubule catastrophe.
Reference summary
- PubMed ID
- PMID:25763975
- Title
- Kinesin-8 motors improve nuclear centering by promoting microtubule catastrophe.
- Authors
- Glunčić M, Maghelli N, Krull A, Krstić V, Ramunno-Johnson D, Pavin N, Tolić IM
- Citation
- Phys Rev Lett 2015 Feb 20;114(7):078103
- Publication year
- 2015
- Abstract
- In fission yeast, microtubules push against the cell edge, thereby positioning the nucleus in the cell center. Kinesin-8 motors regulate microtubule catastrophe; however, their role in nuclear positioning is not known. Here we develop a physical model that describes how kinesin-8 motors affect nuclear centering by promoting a microtubule catastrophe. Our model predicts the improved centering of the nucleus in the presence of motors, which we confirmed experimentally in living cells. The model also predicts a characteristic time for the recentering of a displaced nucleus, which is supported by our experiments where we displaced the nucleus using optical tweezers.
