Reference - PMID:28103117 - Wee1 and Cdc25 are controlled by conserved PP2A-dependent mechanisms in fission yeast.

Reference summary

PubMed ID

PMID:28103117

Title

Wee1 and Cdc25 are controlled by conserved PP2A-dependent mechanisms in fission yeast.

Authors

Lucena R, Alcaide-Gavilán M, Anastasia SD, Kellogg DR

Citation

Cell Cycle 2017 Mar 04;16(5):428-435

Publication year

2017

Abstract

Wee1 and Cdc25 are conserved regulators of mitosis. Wee1 is a kinase that delays mitosis via inhibitory phosphorylation of Cdk1, while Cdc25 is a phosphatase that promotes mitosis by removing the inhibitory phosphorylation. Although Wee1 and Cdc25 are conserved proteins, it has remained unclear whether their functions and regulation are conserved across diverse species. Here, we analyzed regulation of Wee1 and Cdc25 in fission yeast. Both proteins undergo dramatic cell cycle-dependent changes in phosphorylation that are dependent upon PP2A associated with the regulatory subunit Pab1. The mechanisms that control Wee1 and Cdc25 in fission yeast appear to share similarities to those in budding yeast and vertebrates, which suggests that there may be common mechanisms that control mitotic entry in all eukaryotic cells.

Annotation