Reference - PMID:30294483 - LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast.
Reference summary
- PubMed ID
- PMID:30294483
- Title
- LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast.
- Authors
- Park YD, Kwon SJ, Bae KS, Park HM
- Citation
- Mycobiology 2018;46(3):236-241
- Publication year
- 2018
- Abstract
- The cation-dependent galactose-specific flocculation activity of the Schizosaccharomyces pombe null mutant of lkh1 + , the gene encoding LAMMER kinase homolog, has previously been reported by our group. Here, we show that disruption of prk1 + , another flocculation associated regulatory kinase encoding gene, also resulted in cation-dependent galactose-specific flocculation. Deletion of prk1 increased the flocculation phenotype of the lkh1 + null mutant and its overexpression reversed the flocculation of cells caused by lkh1 deletion. Transcript levels of prk1 + were also decreased by lkh1 + deletion. Cumulatively, these results indicate that Lkh1 is one of the negative regulators acting upstream of Prk1, regulating non-sexual flocculation in fission yeast.
