Reference - PMID:32317395 - Translesion synthesis polymerases contribute to meiotic chromosome segregation and cohesin dynamics in S chizosaccharomyces pombe .
Reference summary
- PubMed ID
- PMID:32317395
- Title
- Translesion synthesis polymerases contribute to meiotic chromosome segregation and cohesin dynamics in S chizosaccharomyces pombe .
- Authors
- Mastro TL, Tripathi VP, Forsburg SL
- Citation
- J Cell Sci 2020 May 22;133(10)
- Publication year
- 2020
- Abstract
- Translesion synthesis polymerases (TLSPs) are non-essential error-prone enzymes that ensure cell survival by facilitating DNA replication in the presence of DNA damage. In addition to their role in bypassing lesions, TLSPs have been implicated in meiotic double-strand break repair in several systems. Here, we examine the joint contribution of four TLSPs to meiotic progression in the fission yeast Schizosaccharomyces pombe. We observed a dramatic loss of spore viability in fission yeast lacking all four TLSPs, which is accompanied by disruptions in chromosome segregation during meiosis I and II. Rec8 cohesin dynamics are altered in the absence of the TLSPs. These data suggest that the TLSPs contribute to multiple aspects of meiotic chromosome dynamics.
