Reference - PMID:32406497 - Establishing correct kinetochore-microtubule attachments in mitosis and meiosis.
Reference summary
- PubMed ID
- PMID:32406497
- Title
- Establishing correct kinetochore-microtubule attachments in mitosis and meiosis.
- Authors
- Cairo G, Lacefield S
- Citation
- Essays Biochem 2020 Sep 04;64(2):277-287
- Publication year
- 2020
- Abstract
- Faithful chromosome segregation in mitosis and meiosis requires that chromosomes properly attach to spindle microtubules. Initial kinetochore-microtubule attachments are often incorrect and rely on error correction mechanisms to release improper attachments, allowing the formation of new attachments. Aurora B kinase and, in mammalian germ cells, Aurora C kinase function as the enzymatic component of the Chromosomal Passenger Complex (CPC), which localizes to the inner centromere/kinetochore and phosphorylates kinetochore proteins for microtubule release during error correction. In this review, we discuss recent findings of the molecular pathways that regulate the chromosomal localization of Aurora B and C kinases in human cell lines, mice, fission yeast, and budding yeast. We also discuss differences in the importance of localization pathways between mitosis and meiosis.
