Reference - PMID:32723864 - Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.
Reference summary
- PubMed ID
- PMID:32723864
- Title
- Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.
- Authors
- Zheng F, Dong F, Yu S, Li T, Jian Y, Nie L, Fu C
- Citation
- J Biol Chem 2020 Sep 18;295(38):13287-13298
- Publication year
- 2020
- Abstract
- The spindle apparatus segregates bi-oriented sister chromatids during mitosis but mono-oriented homologous chromosomes during meiosis I. It has remained unclear if similar molecular mechanisms operate to regulate spindle dynamics during mitosis and meiosis I. Here, we employed live-cell microscopy to compare the spindle dynamics of mitosis and meiosis I in fission yeast cells and demonstrated that the conserved kinesin-14 motor Klp2 plays a specific role in maintaining metaphase spindle length during meiosis I but not during mitosis. Moreover, the maintenance of metaphase spindle stability during meiosis I requires the synergism between Klp2 and the conserved microtubule cross-linker Ase1, as the absence of both proteins causes exacerbated defects in metaphase spindle stability. The synergism is not necessary for regulating mitotic spindle dynamics. Hence, our work reveals a new molecular mechanism underlying meiotic spindle dynamics and provides insights into understanding differential regulation of meiotic and mitotic events.
