Reference - PMID:33164662 - Atg11-mediated activation of Atg1 kinase in fission yeast.
Reference summary
- PubMed ID
- PMID:33164662
- Title
- Atg11-mediated activation of Atg1 kinase in fission yeast.
- Authors
- Pan ZQ, Du LL
- Citation
- Autophagy 2021 Feb;17(2):584-585
- Publication year
- 2021
- Abstract
- The protein kinase Atg1 is a key player in macroautophagy/autophagy, but how its activity is regulated in various organisms is inadequately understood. Our recent study showed that in the fission yeast Schizosaccharomyces pombe , Atg1 kinase activity depends on Atg11, but not Atg13, Atg17, or Atg101. Notably, a 62 amino acid region of S. pombe Atg11 is sufficient for activating Atg1. This region is composed of two parts: an Atg1-binding domain and a homodimerization domain. Atg11 uses this region to dimerize Atg1. Dimerized Atg1 is activated through cis-autophosphorylation.
