Reference - PMID:33888556 - Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I.
Reference summary
- PubMed ID
- PMID:33888556
- Title
- Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I.
- Authors
- Ma W, Zhou J, Chen J, Carr AM, Watanabe Y
- Citation
- Genes Dev 2021 May 01;35(9-10):692-697
- Publication year
- 2021
- Abstract
- The conserved meiosis-specific kinetochore regulator, meikin (Moa1 in fission yeast) plays a central role in establishing meiosis-specific kinetochore function. However, the underlying molecular mechanisms remain elusive. Here, we show how Moa1 regulates centromeric cohesion protection, a function that has been previously attributed to shugoshin (Sgo1). Moa1 is known to associate with Plo1 kinase. We explore Plo1-dependent Rec8 phosphorylation and identify a key phosphorylation site required for cohesion protection. The phosphorylation of Rec8 by Moa1-Plo1 potentiates the activity of PP2A associated with Sgo1. This leads to dephosphorylation of Rec8 at another site, which thereby prevents cleavage of Rec8 by separase.
