Reference - PMID:34864879 - Complementation of fission yeast kinesin-5/Cut7 with human Eg5 provides a versatile platform for screening of anticancer compounds.
Reference summary
- PubMed ID
- PMID:34864879
- Title
- Complementation of fission yeast kinesin-5/Cut7 with human Eg5 provides a versatile platform for screening of anticancer compounds.
- Authors
- Hwang W, Toda T, Yukawa M
- Citation
- Biosci Biotechnol Biochem 2022 Jan 24;86(2):254-259
- Publication year
- 2022
- Abstract
- Kinesin-5 family proteins are essential for bipolar spindle assembly to ensure mitotic fidelity. Here, we demonstrate evolutionary functional conservation of kinesin-5 between human and fission yeast. Human Eg5 expressed in the nucleus replaces fission yeast counterpart Cut7. Intriguingly, Eg5 overproduction results in cytotoxicity. This phenotype provides a useful platform for the development of novel kinesin-5 inhibitors as anticancer drugs.
