Reference - PMID:35416247 - Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast.

Reference summary

PubMed ID

PMID:35416247

Title

Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast.

Authors

Ohtsuka H, Matsumoto T, Mochida T, Shimasaki T, Shibuya M, Yamamoto Y, Aiba H

Citation

Biosci Biotechnol Biochem 2022 May 24;86(6):775-779

Publication year

2022

Abstract

Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition effect. Based on the comparative analysis of these compounds, we propose that Tschimganine has at least 2 targets: one extends the lifespan and the other inhibits growth.

Annotation