Reference - PMID:37156916 - Fast and accurate protein structure search with Foldseek.
Reference summary
- PubMed ID
- PMID:37156916
- Title
- Fast and accurate protein structure search with Foldseek.
- Authors
- van Kempen M, Kim SS, Tumescheit C, Mirdita M, Lee J, Gilchrist CLM, Söding J, Steinegger M
- Citation
- Nat Biotechnol 2024 Feb;42(2):243-246
- Publication year
- 2024
- Abstract
- As structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a structural alphabet. Foldseek decreases computation times by four to five orders of magnitude with 86%, 88% and 133% of the sensitivities of Dali, TM-align and CE, respectively.
Orthologs
- CETN2 (HGNC:1867) Homo sapiens
- CAF130 (YGR134W) Saccharomyces cerevisiae
- MVK (HGNC:7530) Homo sapiens
- MISO1 (HGNC:26434) Homo sapiens
- PEX26 (HGNC:22965) Homo sapiens
