Reference - PMID:38415071 - The Cdc14 phosphatase, Clp1, does not affect genome expression.

Reference summary

PubMed ID

PMID:38415071

Title

The Cdc14 phosphatase, Clp1, does not affect genome expression.

Authors

Lopez Maury L, Ren L, Hassan S, Bähler J, Gould KL

Citation

MicroPubl Biol 2024;2024

Publication year

2024

Abstract

Schizosaccharomyces pombe Clp1 is a Cdc14-family phosphatase that reverses mitotic Cdk1 phosphorylation. Despite evolutionary conservation, Clp1 's mammalian orthologs do not share this function. Rather, higher eukaryotic Cdc14 enzymes act in DNA repair, ciliogenesis, and gene regulation. To examine if Clp1 regulates gene expression, we compared the transcriptional profiles of cells lacking Clp1 function to that of wildtype. Because clp1∆ cells are sensitive to the actin depolymerizing drug, LatrunculinA, we also investigated whether a transcriptional response was involved. Our results indicate that Clp1 does not detectably affect gene expression and highlight the organism-specific functions of this conserved phosphatase family.

Annotation