Reference - PMID:38424265 - Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe.
Reference summary
- PubMed ID
- PMID:38424265
- Title
- Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe.
- Authors
- Maekawa Y, Matsui K, Okamoto K, Shimasaki T, Ohtsuka H, Tani M, Ihara K, Aiba H
- Citation
- Mol Genet Genomics 2024 Feb 29;299(1):20
- Publication year
- 2024
- Abstract
- To understand the lifespan of higher organisms, including humans, it is important to understand lifespan at the cellular level as a prerequisite. So, fission yeast is a good model organism for the study of lifespan. To identify the novel factors involved in longevity, we are conducting a large-scale screening of long-lived mutant strains that extend chronological lifespan (cell survival in the stationary phase) using fission yeast. One of the newly acquired long-lived mutant strains (No.98 mutant) was selected for analysis and found that the long-lived phenotype was due to a missense mutation (92Phe → Ile) in the plb1 + gene. plb1 + gene in fission yeast is a nonessential gene encoding a homolog of phospholipase B, but its functions under normal growth conditions, as well as phospholipase B activity, remain unresolved. Our analysis of the No.98 mutant revealed that the plb1 mutation reduces the integrity of the cellular membrane and cell wall and activates Sty1 via phosphorylation.
