Reference - PMID:42024429 - Mitochondrial NADP+-isocitrate dehydrogenase Idp1 involves CoQ biosynthesis in parallel with NAD kinase Pos5.
Reference summary
- PubMed ID
- PMID:42024429
- Title
- Mitochondrial NADP+-isocitrate dehydrogenase Idp1 involves CoQ biosynthesis in parallel with NAD kinase Pos5.
- Authors
- Nishihara S, Matsuo Y, Kawamukai M
- Citation
- Biosci Biotechnol Biochem 2026 Apr 23;
- Publication year
- 2026
- Abstract
- Mitochondrial NADPH is synthesized by isocitrate dehydrogenase (Idp1) from NADP+ and NAD kinase (Pos5) from NADH. Coenzyme Q levels in Schizosaccharomyces pombe were decreased by deletion of idp1 and further lowered by deletion of pos5. The NADP+/NADPH ratio of the ∆idp1 strain shifted to an oxidized state. The mitochondrial NADPH pool and its redox state are critical for CoQ biosynthesis.
