Reference - PMID:42136729 - Cmp7-dependent recruitment of Alx1 to a mitotic nuclear envelope hole in Schizosaccharomyces pombe .
Reference summary
- PubMed ID
- PMID:42136729
- Title
- Cmp7-dependent recruitment of Alx1 to a mitotic nuclear envelope hole in Schizosaccharomyces pombe .
- Authors
- Genereux KD, Walker ON, Benders SO, Le TT, Ader NR
- Citation
- MicroPubl Biol 2026;2026
- Publication year
- 2026
- Abstract
-  The nuclear envelope maintains nucleocytoplasmic compartmentalization. Divergent strategies exist to accommodate the nuclear envelope during mitotic chromatin segregation. While the endosomal sorting complexes required for transport (ESCRT) machinery drives nuclear envelope remodeling during this process, recent work in Schizosaccharomyces japonicus suggests an ESCRT-independent pathway promoting nucleocytoplasmic compartmentalization mediated by Alx1 . We investigate if this ESCRT-independent pathway is conserved in Schizosaccharomyces pombe. We find Alx1-GFP is recruited to a mitotic nuclear envelope hole in S. pombe , but that recruitment depends on the ESCRT machinery. Our data suggest diverse strategies of mitotic nuclear envelope remodeling necessitate varying strategies of promoting nucleocytoplasmic compartmentalization.
