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Reference - PMID:7851743 - Mutations which reduce levels of pyruvate dehydrogenase in Schizosaccharomyces pombe cause a requirement for arginine or glutamine.

Reference summary

PubMed ID
PMID:7851743
Title
Mutations which reduce levels of pyruvate dehydrogenase in Schizosaccharomyces pombe cause a requirement for arginine or glutamine.
Authors
Cavan G, MacDonald D
Citation
FEMS Microbiol Lett 1994 Dec 15;124(3):361-5
Publication year
1994
Abstract
Forty-four mutants of Schizosaccharomyces pombe were isolated which required supplementation with arginine or glutamine. These mutants appear to define three genes, provisionally named agg1, agg2 and agg3 (arginine, glutamine requiring). Mutants in all three genes were found to have reduced levels of pyruvate dehydrogenase compared to wild-type.

Annotation

GO biological process

GO:0006086 - pyruvate decarboxylation to acetyl-CoA

Genes:

Single locus phenotype

FYPO:0000983 - decreased glutamate dehydrogenase (NADP+) activity

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Genotypes:

FYPO:0000916 - decreased pyruvate dehydrogenase activity

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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FYPO:0000921 - increased aconitate hydratase activity

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FYPO:0000919 - increased citrate (Si)-synthase activity

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FYPO:0000923 - increased isocitrate dehydrogenase (NAD+) activity

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FYPO:0000981 - normal glutamate dehydrogenase (NAD+) activity

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FYPO:0000914 - normal glutamate-ammonia ligase activity

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FYPO:0001357 - normal vegetative cell population growth

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