Reference - PMID:7889932 - Crystal structure of casein kinase-1, a phosphate-directed protein kinase.
Reference summary
- PubMed ID
- PMID:7889932
- Title
- Crystal structure of casein kinase-1, a phosphate-directed protein kinase.
- Authors
- Xu RM, Carmel G, Sweet RM, Kuret J, Cheng X
- Citation
- EMBO J 1995 Mar 01;14(5):1015-23
- Publication year
- 1995
- Abstract
- The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.
