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Reference - PMID:8121488 - Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.

Reference summary

PubMed ID
PMID:8121488
Title
Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.
Authors
Moreno S, Nurse P
Citation
Nature 1994 Jan 20;367(6460):236-42
Publication year
1994
Abstract
The rum1+ gene is identified as a new regulator of G1 progression in fission yeast. It influences three aspects of G1 regulation: determination of the length of G1, dependence of S phase upon completion of mitosis, and restraint of mitosis until G1 is finished. We propose that it has a central role in regulating the G1 phase of the cell cycle.

Annotation

GO biological process

GO:0031568 - mitotic G1 cell size control checkpoint signaling

Genes:

GO:0007089 - traversing start control point of mitotic cell cycle

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GO molecular function

GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity

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Multi-locus phenotype

FYPO:0001425 - abnormal negative regulation of mitotic DNA replication initiation resulting in complete rereplication

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Genotypes:

FYPO:0001053 - cut, normal size cell

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Genotypes:

FYPO:0007476 - decreased duration of cell cycle arrest in mitotic G1 phase

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Genotypes:

FYPO:0000453 - DNA content decreased during vegetative growth

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Single locus phenotype

FYPO:0005097 - abnormal cell cycle arrest in mitotic G1 phase

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Genotypes:

FYPO:0001425 - abnormal negative regulation of mitotic DNA replication initiation resulting in complete rereplication

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FYPO:0003345 - abolished cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

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Genotypes:

FYPO:0002083 - inviable swollen elongated cell with enlarged nucleus

Genes:

Genotypes:

FYPO:0000333 - mitotic G1/S phase transition delay

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Genotypes:

FYPO:0000398 - premature mitotic G1/S phase transition

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FYPO:0000280 - sterile

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