Reference - PMID:8557102 - Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast.
Reference summary
- PubMed ID
- PMID:8557102
- Title
- Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast.
- Authors
- Kato T, Okazaki K, Murakami H, Stettler S, Fantes PA, Okayama H
- Citation
- FEBS Lett 1996 Jan 15;378(3):207-12
- Publication year
- 1996
- Abstract
- We identified the phh1+ gene that encodes a MAP kinase as the effector of Wis1 MAP kinase kinase in fission yeast, which is highly homologous with HOG1 of S. cerevisiae. Heterothalic phh1 dsiruptant is phenotypically indistinguishable from wis1 deletion mutant, both displaying the same extent of partial sterility and enhanced sensitivity to a variety of stress. In phh1 disruptant, nitrogen starvation-induced expression of ste11+, a key controller of sexual differentiation, is markedly diminished. Ectopic expression of ste11+ effectively restores fertility, but not stress resistance, to the phh1 disruptant. These data show that stress signal, mediated by a MAP kinase, is required for efficient start of sexual differentiation.
