Reference - PMID:9459302 - Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe.
Reference summary
- PubMed ID
- PMID:9459302
- Title
- Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe.
- Authors
- Motegi F, Nakano K, Kitayama C, Yamamoto M, Mabuchi I
- Citation
- FEBS Lett 1997 Dec 29;420(2-3):161-6
- Publication year
- 1997
- Abstract
- We cloned the myo3+ gene of Schizosaccharomyces pombe which encodes a type-II myosin heavy chain. myo3 null cells showed a defect in cytokinesis under certain conditions. Overproduction of Myo3 also showed a defect in cytokinesis. Double mutant analysis indicated that Myo3 genetically interacts with Cdc8 tropomyosin and actin. Myo3 may be implicated in cytokinesis and stabilization of F-actin cables. Moreover, the function of Myo2 can be replaced by overexpressed Myo3. We observed a modest synthetic interaction between Myo2 and Myo3. Thus, Myo2 and Myo3 seem to cooperate in the formation of the F-actin ring in S. pombe.
