Reference - PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.

Reference summary

PubMed ID

PMID:9671458

Title

An RNA binding protein negatively controlling differentiation in fission yeast.

Authors

Tsukahara K, Yamamoto H, Okayama H

Citation

Mol Cell Biol 1998 Aug;18(8):4488-98

Publication year

1998

Abstract

The fission yeast Schizosaccharomyces pombe starts sexual development when starved for nutrients and simultaneously activated by mating pheromones. We have identified a new gene regulating the onset of this process. This gene, called nrd1(+), encodes a typical RNA binding protein that preferentially binds poly(U). Deletion of nrd1(+) causes cells to initiate sexual development without nutrient starvation. We have found that the biological role of nrd1(+) is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.

Annotation