PomBase home

Reference - PMID:9730284 - The uracil permease of Schizosaccharomyces pombe: a representative of a family of 10 transmembrane helix transporter proteins of yeasts.

Reference summary

PubMed ID
PMID:9730284
Title
The uracil permease of Schizosaccharomyces pombe: a representative of a family of 10 transmembrane helix transporter proteins of yeasts.
Authors
de Montigny J, Straub ML, Wagner R, Bach ML, Chevallier MR
Citation
Yeast 1998 Aug;14(11):1051-9
Publication year
1998
Abstract
The uracil permease gene of Schizosaccharomyces pombe was cloned and sequenced. The deduced protein sequence shares strong similarities with five open reading frames from Saccharomyces cerevisiae, namely the uracil permease encoded by the FUR4 gene, the allantoin permease encoded by DAL4, a putative uridine permease (YBL042C) and two unknown ORFs YOR071c and YLR237w. A topological model retaining ten transmembrane helices, based on predictions and on experimental data established for the uracil permease of S. cerevisiae by Galan and coworkers (1996), is discussed for the four closest proteins of this family of transporters. The sequence of the uracil permease gene of S. pombe has been deposited in the EMBL data bank under Accession Number X98696.

Annotation

GO molecular function

GO:0015505 - uracil:monoatomic cation symporter activity

Genes:

Single locus phenotype

FYPO:0001986 - resistance to 5-fluorouracil

Genes:

Genotypes: