Reference - PMID:9774280 - Two modes of survival of fission yeast without telomerase.
Reference summary
- PubMed ID
- PMID:9774280
- Title
- Two modes of survival of fission yeast without telomerase.
- Authors
- Nakamura TM, Cooper JP, Cech TR
- Citation
- Science 1998 Oct 16;282(5388):493-6
- Publication year
- 1998
- Abstract
- Deletion of the telomerase catalytic subunit gene trt1+ in Schizosaccharomyces pombe results in death for the majority of cells, but a subpopulation survives. Here it is shown that most survivors have circularized all of their chromosomes, whereas a smaller number maintain their telomeres presumably through recombination. When the telomeric DNA-binding gene taz1+ is also deleted, trt1- taz1- survivors use the recombinational mode more frequently. Moreover, the massive elongation of telomeres in taz1- cells is absent in the double mutant. Thus, Taz1p appears to regulate telomeric recombination as well as telomerase activity in fission yeast.
