Reference - PMID:9857180 - Fission yeast Csk1 is a CAK-activating kinase (CAKAK).
Reference summary
- PubMed ID
- PMID:9857180
- Title
- Fission yeast Csk1 is a CAK-activating kinase (CAKAK).
- Authors
- Hermand D, Pihlak A, Westerling T, Damagnez V, Vandenhaute J, Cottarel G, Mäkelä TP
- Citation
- EMBO J 1998 Dec 15;17(24):7230-8
- Publication year
- 1998
- Abstract
- Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe, CAK has been identified as a complex homologous to CDK7-cyclin H (Mcs6-Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6-Mcs2 CAK defining Csk1 as a CAK-activating kinase (CAKAK).
