id: gomodel:678073a900003902
title: L-proline biosynthetic process (GO:0055129),  proline catabolic process to
  glutamate (GO:0010133), glutamine biosynthetic process (GO:0006542)
taxon: NCBITaxon:4896
status: production
activities:
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    term: CHEBI:36080
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    term: GO:0031966
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      reference: GO_REF:0000033
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      - PomBase:SPAC3H1.07
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    term: PomBase:SPBP26C9.02c
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      date: '2025-03-21'
      provided_by:
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    term: GO:0005829
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      reference: PMID:20460254
      provenances:
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      date: '2025-03-21'
      provided_by:
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      date: '2025-03-21'
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    term: PomBase:SPAPYUG7.05
  molecular_function:
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    evidence:
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    term: PomBase:SPBC21C3.08c
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      provenances:
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      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58066
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:29985
- id: gomodel:678073a900003902/67e5e74400003980
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-09'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:36080
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0015193
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-09'
      provided_by:
      - http://www.pombase.org
    term: GO:0031966
  part_of:
    type: BiologicalProcessAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-09'
      provided_by:
      - http://www.pombase.org
    term: GO:0015824
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-09'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:17203
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-09'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:17203
- id: gomodel:678073a900003902/678073a900004029
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000357758
      - FB:FBgn0003423
      - RGD:1590932
      - TAIR:locus:2166645
      - SGD:S000004132
      - TAIR:locus:2089706
      - UniProtKB:O43272
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC70.03c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004657
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - UniProtKB:P09368
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000357758
      - SGD:S000004132
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0010133
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-22'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:17203
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:15893
- id: gomodel:678073a900003902/678073a900003943
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000115542
      - SGD:S000002708
      - UniProtKB:P0A7B5
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC17H9.13c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004349
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000115542
      - UniProtKB:P0A7B5
      - TAIR:locus:2200580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000269
      reference: PMID:17248775
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0055129
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:29985
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58274
- id: gomodel:678073a900003902/678073a900003934
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000115463
      - UniProtKB:P07004
      - FB:FBgn0037146
      - UniProtKB:P54886
      - SGD:S000005850
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC821.11
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004350
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000269
      reference: PMID:17248775
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0055129
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000115463
      - UniProtKB:P07004
      - FB:FBgn0037146
      - UniProtKB:P54886
      - SGD:S000005850
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58274
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000115463
      - UniProtKB:P07004
      - FB:FBgn0037146
      - UniProtKB:P54886
      - SGD:S000005850
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58274
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000115463
      - UniProtKB:P07004
      - FB:FBgn0037146
      - UniProtKB:P54886
      - SGD:S000005850
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-01-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:58066
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-01-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:15893
objects:
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: GO:0004053
  label: arginase activity
  type: gocam:Object
- id: PomBase:SPBP26C9.02c
  label: car1 Spom
  type: gocam:Object
- id: GO:0010121
  label: L-arginine catabolic process to proline via ornithine
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:16199
  label: urea
  type: gocam:Object
- id: CHEBI:17203
  label: L-proline
  type: gocam:Object
- id: GO:0004356
  label: glutamine synthetase activity
  type: gocam:Object
- id: PomBase:SPAC23H4.06
  label: gln1 Spom
  type: gocam:Object
- id: GO:0006542
  label: glutamine biosynthetic process
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:28938
  label: ammonium
  type: gocam:Object
- id: CHEBI:58359
  label: L-glutamine zwitterion
  type: gocam:Object
- id: GO:0015186
  label: L-glutamine transmembrane transporter activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0006868
  label: glutamine transport
  type: gocam:Object
- id: GO:0031966
  label: mitochondrial membrane
  type: gocam:Object
- id: GO:0015193
  label: L-proline transmembrane transporter activity
  type: gocam:Object
- id: GO:0015824
  label: proline transport
  type: gocam:Object
- id: PomBase:SPBC21C3.08c
  label: car2 Spom
  type: gocam:Object
- id: GO:0004587
  label: ornithine aminotransferase activity
  type: gocam:Object
- id: CHEBI:46911
  label: L-ornithinium(1+)
  type: gocam:Object
- id: CHEBI:35179
  label: 2-oxo monocarboxylic acid anion
  type: gocam:Object
- id: GO:0004350
  label: glutamate-5-semialdehyde dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPAC821.11
  label: pro1 Spom
  type: gocam:Object
- id: GO:0055129
  label: L-proline biosynthetic process
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0004349
  label: glutamate 5-kinase activity
  type: gocam:Object
- id: PomBase:SPAC17H9.13c
  label: pro2 Spom
  type: gocam:Object
- id: GO:0004735
  label: pyrroline-5-carboxylate reductase activity
  type: gocam:Object
- id: PomBase:SPAPYUG7.05
  label: pro3 Spom
  type: gocam:Object
- id: CHEBI:29985
  label: L-glutamate(1-)
  type: gocam:Object
- id: CHEBI:58274
  label: L-gamma-glutamyl phosphate(2-)
  type: gocam:Object
- id: CHEBI:58066
  label: L-glutamic 5-semialdehyde zwitterion
  type: gocam:Object
- id: CHEBI:15893
  label: 1-pyrroline-5-carboxylate
  type: gocam:Object
- id: GO:0004657
  label: proline dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPCC70.03c
  label: put1 Spom
  type: gocam:Object
- id: GO:0010133
  label: L-proline catabolic process to L-glutamate
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0003842
  label: L-glutamate gamma-semialdehyde dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPBC24C6.04
  label: put2 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-04-22'
  provided_by:
  - http://www.pombase.org
