Phenotype ontology term - FYPO:0000140 - cellular metabolism phenotype

FYPO:0008420 - abnormal dolichol-linked oligosaccharide biosynthetic process

References:

• PMID:34851357

Genes:

• alg10 (SPAC56F8.06c)
• alg12 (SPBC1734.12c)
• alg3 (SPAC7D4.06c)
• alg6 (SPBC342.01c)
• alg8 (SPAC17C9.07)
• alg9 (SPAC1834.05)

Genotypes:

• alg10delta alg12delta
• alg10delta alg3delta
• alg10delta alg9delta
• alg12delta alg6delta
• alg12delta alg8delta
• alg3delta alg6delta
• alg3delta alg8delta
• alg6delta alg9delta
• alg8delta alg9delta

FYPO:0002553 - abnormal double-strand break processing

References:

• PMID:23211746
• PMID:27098497

Genes:

• ast1 (SPCC962.05)
• csn1 (SPBC215.03c)
• csn5 (SPAC1687.13c)
• ddb1 (SPAC17H9.10c)
• exo1 (SPBC29A10.05)
• htb1 (SPCC622.09)
• rad2 (SPAC3G6.06c)
• rhp6 (SPAC18B11.07c)
• rqh1 (SPAC2G11.12)
• spd1 (SPAC29B12.03)
• wdr70 (SPAC343.17c)

Genotypes:

• ast1delta exo1+(wild type)[Knockdown] rad2delta
• csn1delta spd1delta
• csn1delta spd1delta wdr70delta
• csn5delta spd1delta
• csn5delta spd1delta wdr70delta
• ddb1delta spd1delta
• exo1delta spd1delta
• exo1delta spd1delta wdr70delta
• htb1-K119R(K120R aa) spd1delta
• rhp6delta spd1delta
• rqh1delta spd1delta
• rqh1delta spd1delta wdr70delta
• spd1delta wdr70delta

FYPO:0005658 - abnormal frequency of meiotic crossover associated with gene conversion

References:

• PMID:25414342

Genes:

• dmc1 (SPAC8E11.03c)
• fml1 (SPAC9.05)
• rdl1 (SPAC17H9.03c)
• rlp1 (SPBC1685.11)
• rqh1 (SPAC2G11.12)

Genotypes:

• dmc1delta rlp1delta rqh1delta
• dmc1delta rqh1delta
• fml1delta rdl1delta
• fml1delta rlp1delta

FYPO:0000468 - abnormal mating type switching

References:

• PMID:35908934
• PMID:36951094

Genes:

• dcr1 (SPCC188.13c)
• pcr1 (SPAC21E11.03c)
• set1 (SPCC306.04c)
• shf1 (SPAC22F8.12c)
• swi2 (SPAC1142.03c)
• swi6 (SPAC664.01c)

Genotypes:

• dcr1delta pcr1delta
• dcr1delta set1delta
• dcr1delta shf1delta
• pcr1delta set1delta
• pcr1delta shf1delta
• set1delta shf1delta
• set1delta swi2-5A(F271A,D272A,V274A,V275A,I276A aa)
• set1delta swi2-AT12-AA(G219A,R220A,P221A,G242A,R243A,P244A aa)
• swi2-5A(F271A,D272A,V274A,V275A,I276A aa) swi6delta
• swi2-AT12-AA(G219A,R220A,P221A,G242A,R243A,P244A aa) swi6delta

FYPO:0003564 - abnormal meiotic DNA double-strand break formation

References:

• PMID:25579976

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)

Genotypes:

• hhp1+(wild type)[Knockdown] hhp2delta

FYPO:0001343 - abnormal mitotic DNA replication

References:

• PMID:9303312

Genes:

• cdc10 (SPBC336.12c)
• cdc13 (SPBC582.03)
• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)

Genotypes:

• cdc10-V50(H362Y aa) cdc13+(wild type)[Knockdown] cig1delta cig2delta

FYPO:0000481 - abnormal mitotic recombination

References:

• PMID:21098121

Genes:

• pot1 (SPAC26H5.06)
• rqh1 (SPAC2G11.12)

Genotypes:

• pot1delta rqh1-K547A(aa)

FYPO:0007409 - abnormal mRNA alternative polyadenylation

References:

• PMID:34389684

Genes:

• nc-tgp1 (SPNCRNA.1698)
• seb1 (SPAC222.09)

Genotypes:

• nc-tgp1-PAS-mutant(unknown) seb1-G476S(aa)

FYPO:0000625 - abnormal premeiotic DNA replication

References:

• PMID:11854402

Genes:

• mcm4 (SPCC16A11.17)
• pat1 (SPBC19C2.05)

Genotypes:

• mcm4-tstd(Ub-DHFRts-mcm4) pat1-114(V155G,P219S,L291F aa)

FYPO:0000329 - abnormal protein modification during vegetative growth

References:

• PMID:26221037

Genes:

• nup132 (SPAC1805.04)
• rpn12 (SPBC16G5.01)
• ufd1 (SPBC16A3.09c)

Genotypes:

• mts3-1(unknown) nup132delta
• nup132delta ufd1-1(P76S aa)

FYPO:0002447 - abnormal protein N-linked glycosylation during vegetative growth

References:

• PMID:20854854

Genes:

• alg3 (SPAC7D4.06c)
• och1 (SPAC1006.05c)

Genotypes:

• alg3delta och1delta

FYPO:0000775 - abnormal protein phosphorylation during vegetative growth

References:

• PMID:26131711

Genes:

• cdc13 (SPBC582.03)
• cdc2 (SPBC11B10.09)
• mik1 (SPBC660.14)
• wee1 (SPCC18B5.03)

Genotypes:

• cdc13-245(E255R aa) cdc2-1w(G146D aa)
• cdc2-1w(G146D aa) mik1delta
• cdc2-1w(G146D aa) wee1delta

FYPO:0003596 - abnormal snRNA 3'-end processing

References:

• PMID:26213367

Genes:

• cid14 (SPAC12G12.13c)
• mpn1 (SPAC23C11.10)

Genotypes:

• cid14delta mpn1delta

FYPO:0000122 - abnormal telomere maintenance during vegetative growth

References:

• PMID:29774234

Genes:

• stn1 (SPBC409.12c)
• taz1 (SPAC16A10.07c)

Genotypes:

• stn1-226(I226A,L227A,L229A aa) taz1delta

FYPO:0002254 - abnormal telomere morphology during vegetative growth

References:

• PMID:18160711

Genes:

• est1 (SPBC2D10.13)
• pku70 (SPCC126.02c)
• rad3 (SPBC216.05)
• taz1 (SPAC16A10.07c)
• trt1 (SPBC29A3.14c)

Genotypes:

• est1delta taz1delta trt1-D590A(aa)
• est1delta taz1delta trt1-D743A(aa)
• est1delta taz1delta trt1delta
• pku70delta taz1delta trt1-D590A(aa)
• pku70delta taz1delta trt1-D743A(aa)
• pku70delta taz1delta trt1delta
• rad3delta taz1delta trt1delta
• taz1delta trt1delta

FYPO:0004065 - abnormal transcription elongation from RNA polymerase II promoter

References:

• PMID:26173815

Genes:

• ncs1 (SPAC18B11.04)
• set3 (SPAC22E12.11c)

Genotypes:

• ncs1delta set3delta

FYPO:0008339 - abolished 3' end uridylation of non-polyadenylated RNA

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)
• cid16 (SPAC17H9.01)

Genotypes:

• cid16delta cid1delta

FYPO:0003593 - abolished anaphase-promoting complex-dependent protein catabolic process

References:

• PMID:23442800

Genes:

• rpn12 (SPBC16G5.01)
• ubc11 (SPCC1259.15c)

Genotypes:

• mts3-1(unknown) ubc11-P93L(aa)

FYPO:0006087 - abolished DNA resection during replication fork processing

References:

• PMID:28475874
• PMID:29215009

Genes:

• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• pku70 (SPCC126.02c)
• rad50 (SPAC1556.01c)
• rad52 (SPAC30D11.10)

Genotypes:

• ctp1delta exo1delta
• ctp1delta exo1delta pku70delta
• exo1delta pku70delta
• exo1delta rad50delta
• exo1delta rad52delta

FYPO:0003485 - abolished DNA synthesis

References:

• PMID:9303312

Genes:

• cdc10 (SPBC336.12c)
• cdc13 (SPBC582.03)
• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)

Genotypes:

• cdc10-V50(H362Y aa) cdc13+(wild type)[Knockdown] cig1delta cig2delta

FYPO:0005399 - abolished double-strand break repair via homologous recombination

References:

• PMID:12628934

Genes:

• pku70 (SPCC126.02c)
• rad51 (SPAC644.14c)

Genotypes:

• pku70delta rad51delta

FYPO:0002472 - abolished histone H2A phosphorylation during cellular response to ionizing radiation

References:

• PMID:15226425
• PMID:15964794
• PMID:21098122
• PMID:26368543
• PMID:29851556
• PMID:30104346

Genes:

• mre11 (SPAC13C5.07)
• nbs1 (SPBC6B1.09c)
• rad3 (SPBC216.05)
• rad50 (SPAC1556.01c)
• tel1 (SPCC23B6.03c)

Genotypes:

• mre11delta rad3delta
• nbs1-10(DD603NN aa) rad3delta
• nbs1-9(F611E,F613E aa) rad3delta
• nbs1-deltaC60(1-60 Δaa) rad3delta
• rad3delta rad50-C1G(C674G aa)
• rad3delta rad50-C2G(C677G aa)
• rad3delta rad50-I1192W(aa)
• rad3delta rad50delta
• rad3delta tel1delta

FYPO:0002597 - abolished histone H2A phosphorylation during vegetative growth

References:

• PMID:26368543
• PMID:29851556

Genes:

• mre11 (SPAC13C5.07)
• rad3 (SPBC216.05)
• rad50 (SPAC1556.01c)
• tel1 (SPCC23B6.03c)

Genotypes:

• mre11delta rad3delta
• rad3delta rad50-I1192W(aa)
• rad3delta tel1delta

FYPO:0002922 - abolished histone H2B-K119 ubiquitination during vegetative growth

References:

• PMID:38718864

Genes:

• gcn5 (SPAC1952.05)
• htb1 (SPCC622.09)
• shf1 (SPAC22F8.12c)
• ubp8 (SPAC13A11.04c)

Genotypes:

• gcn5delta htb1-G52D(G53D aa) shf1delta
• gcn5delta htb1-P102L(P103L aa) shf1delta
• htb1-G52D(G53D aa) shf1delta ubp8delta
• htb1-P102L(P103L aa) shf1delta ubp8delta

FYPO:0006403 - abolished histone H3-K36 dimethylation at promoter during vegetative growth

References:

• PMID:30793188

Genes:

• set2 (SPAC29B12.02c)
• spt6 (SPAC1F7.01c)

Genotypes:

• set2delta3(420-422 Δaa) spt6-1(856-919 Δaa)

FYPO:0002919 - abolished histone H3-K36 methylation during vegetative growth

References:

• PMID:30773398

Genes:

• set2 (SPAC29B12.02c)
• set7 (SPCC297.04c)

Genotypes:

• set2delta set7delta

FYPO:0004170 - abolished histone H3-K9 dimethylation at centromere during vegetative growth

References:

• PMID:24013500
• PMID:32101745

Genes:

• ago1 (SPCC736.11)
• chp2 (SPBC16C6.10)
• clr1 (SPBC2D10.17)
• clr3 (SPBC800.03)
• dcr1 (SPCC188.13c)
• iss1 (SPAC22G7.10)
• mit1 (SPBP35G2.10)
• seb1 (SPAC222.09)

Genotypes:

• ago1delta iss1-deltaC38(327-344 Δaa)
• chp2delta dcr1-R1R2(unknown)
• clr1delta dcr1-R1R2(unknown)
• clr3-735(D232N aa) dcr1-R1R2(unknown)
• dcr1-R1R2(unknown) mit1-K587A(aa)
• dcr1-R1R2(unknown) mit1delta
• dcr1-R1R2(unknown) seb1-1(A45G,T132A,G226A,T1384C,T1450A,A1514G,A1760G nt)

FYPO:0005554 - abolished histone H3-K9 dimethylation at centromere inner repeat during vegetative growth

References:

• PMID:27334362
• PMID:30652128

Genes:

• clr4 (SPBC428.08c)
• dcr1 (SPCC188.13c)
• lem2 (SPAC18G6.10)
• mlo3 (SPBC1D7.04)
• rpb1 (SPBC28F2.12)

Genotypes:

• clr4delta mlo3delta
• clr4delta rpb1-CTD-S7A(r5-r29)(aa)
• dcr1delta lem2delta

FYPO:0004745 - abolished histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

• PMID:16127433
• PMID:24240238
• PMID:25831549
• PMID:28404620
• PMID:28682306
• PMID:30652128
• PMID:31269446
• PMID:39094570
• PMID:40923761

Genes:

• ago1 (SPCC736.11)
• caf1 (SPCC18.06c)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• cul4 (SPAC3A11.08)
• dcr1 (SPCC188.13c)
• mlo3 (SPBC1D7.04)
• mrc1 (SPAC694.06c)
• poz1 (SPAC19G12.13c)
• rpb1 (SPBC28F2.12)
• sir2 (SPBC16D10.07c)
• swd22 (SPAC824.04)

Genotypes:

• ago1delta clr4-I418P(aa)
• ago1delta clr4-IDR-Mut1(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q aa)
• ago1delta clr4-IDR-Mut2(K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
• ago1delta clr4-IDR-Mut3(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q,K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
• ago1delta clr4-W31G(aa)
• ago1delta clr4delta
• ago1delta mrc1-M755A,F758A,L774A(aa)
• ago1delta mrc1-delta(730-797)(aa)
• ago1delta mrc1delta
• ago1delta swd22delta
• caf1delta dcr1delta
• clr3delta dcr1delta
• clr3delta dcr1delta poz1delta
• clr4delta dcr1delta
• clr4delta dcr1delta poz1delta
• clr4delta mlo3delta
• clr4delta rpb1-CTD-S7A(r5-r29)(aa)
• cul4-1(marker gene insertion at 3'-UTR) cul4-K680R(aa)
• dcr1delta poz1delta sir2delta
• dcr1delta sir2delta

FYPO:0006112 - abolished histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

References:

• PMID:28404620
• PMID:40923761

Genes:

• ago1 (SPCC736.11)
• atf1 (SPBC29B5.01)
• caf1 (SPCC18.06c)
• clr4 (SPBC428.08c)
• dcr1 (SPCC188.13c)
• pcr1 (SPAC21E11.03c)

Genotypes:

• ago1delta clr4-IDR-Mut1(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q aa)
• ago1delta clr4-IDR-Mut2(K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
• ago1delta clr4-IDR-Mut3(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q,K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
• atf1delta clr4-IDR-Mut3(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q,K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
• caf1delta dcr1delta
• clr4-IDR-Mut3(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q,K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa) pcr1delta

FYPO:0006111 - abolished histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

• PMID:28404620

Genes:

• caf1 (SPCC18.06c)
• dcr1 (SPCC188.13c)

Genotypes:

• caf1delta dcr1delta

FYPO:0004136 - abolished histone H3-K9 dimethylation at telomere during vegetative growth

References:

• PMID:24240238

Genes:

• dcr1 (SPCC188.13c)
• poz1 (SPAC19G12.13c)

Genotypes:

• dcr1delta poz1-W209A(aa)

FYPO:0003097 - abolished histone H3-K9 methylation at centromere outer repeat during vegetative growth

References:

• PMID:15372076
• PMID:16246721

Genes:

• chp1 (SPAC18G6.02c)
• clr3 (SPBC800.03)
• dcr1 (SPCC188.13c)
• swi6 (SPAC664.01c)

Genotypes:

• chp1delta swi6delta
• clr3delta dcr1delta

FYPO:0008212 - abolished histone H3-K9 methylation at silent mating-type cassette during vegetative growth

References:

• PMID:15218150

Genes:

• ago1 (SPCC736.11)
• atf1 (SPBC29B5.01)
• dcr1 (SPCC188.13c)
• pcr1 (SPAC21E11.03c)
• rdp1 (SPAC6F12.09)

Genotypes:

• ago1delta atf1delta
• ago1delta pcr1delta
• atf1delta dcr1delta
• atf1delta rdp1delta
• dcr1delta pcr1delta
• pcr1delta rdp1delta

FYPO:0002820 - abolished histone H3-K9 methylation at telomere during vegetative growth

References:

• PMID:28404620

Genes:

• ago1 (SPCC736.11)
• caf1 (SPCC18.06c)

Genotypes:

• ago1delta caf1delta

FYPO:0008368 - abolished histone H3-K9 trimethylation at centromere during vegetative growth

References:

• PMID:31883795

Genes:

• ago1 (SPCC736.11)
• amo1 (SPBC15D4.10c)
• pob3 (SPBC609.05)
• rix1 (SPCC4G3.18)

Genotypes:

• ago1delta amo1delta
• ago1delta pob3delta
• ago1delta rix1-E414K(aa)

FYPO:0006813 - abolished histone H3-K9 trimethylation at centromere inner repeat during vegetative growth

References:

• PMID:30652128

Genes:

• clr4 (SPBC428.08c)
• mlo3 (SPBC1D7.04)

Genotypes:

• clr4delta mlo3delta

FYPO:0005843 - abolished histone H3-K9 trimethylation at centromere outer repeat during vegetative growth

References:

• PMID:30652128
• PMID:41316862

Genes:

• clr4 (SPBC428.08c)
• elp1 (SPBC36.07)
• mlo3 (SPBC1D7.04)
• rpb2 (SPAC23G3.01)
• SPBTRNALYS.06

Genotypes:

• SPBTRNALYS.06+(wild type)[Overexpression] elp1delta rpb2-m203(N44Y aa)
• clr4delta mlo3delta

FYPO:0005844 - abolished histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth

References:

• PMID:37279920

Genes:

• epe1 (SPCC622.16c)
• mot2 (SPAC16C9.04c)

Genotypes:

• epe1delta mot2delta

FYPO:0005738 - abolished histone H3-S10 phosphorylation during vegetative growth

References:

• PMID:28404620

Genes:

• caf1 (SPCC18.06c)
• dcr1 (SPCC188.13c)

Genotypes:

• caf1delta dcr1delta

FYPO:0004218 - abolished histone H4-K20 trimethylation during vegetative growth

References:

• PMID:19250904

Genes:

• pdp1 (SPBC29A3.13)

Genotypes:

• pdp1+(wild type) pdp1-F94A(aa)[Overexpression]
• pdp1+(wild type) pdp1-W66A(aa)[Overexpression]

FYPO:0007332 - abolished increase in protein phosphorylation during cellular response to stress in presence of small molecule

References:

• PMID:31932483

Genes:

• win1 (SPAC1006.09)
• wis4 (SPAC9G1.02)

Genotypes:

• win1delta wis4delta

FYPO:0006295 - abolished macroautophagy during nitrogen starvation

References:

• PMID:33534698

Genes:

• gcn1 (SPAC18G6.05c)
• gcn2 (SPBC36B7.09)
• gcn3 (SPCC11E10.07c)

Genotypes:

• gcn1delta gcn2delta gcn3delta

FYPO:0007500 - abolished macroautophagy during sulfur starvation

References:

• PMID:33064910

Genes:

• ecl1 (SPCC70.12c)
• ecl2 (SPBP35G2.16c)
• ecl3 (SPBC8E4.12c)

Genotypes:

• ecl1delta ecl2delta ecl3delta

FYPO:0000469 - abolished mating type switching

References:

• PMID:1620099

Genes:

• swi3 (SPBC30D10.04)
• swi6 (SPAC664.01c)

Genotypes:

• swi3-1(unknown) swi6-115(W269R aa)

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

References:

• PMID:19911044

Genes:

• ctp1 (SPCC338.08)
• hop1 (SPBC1718.02)
• mek1 (SPAC14C4.03)
• mre11 (SPAC13C5.07)
• rad50 (SPAC1556.01c)

Genotypes:

• ctp1delta/ctp1delta hop1delta/hop1delta
• ctp1delta/ctp1delta hop1delta/hop1delta rad50S(K81I aa)/rad50S(K81I aa)
• hop1delta/hop1delta mek1delta/mek1delta rad50S(K81I aa)/rad50S(K81I aa)
• mek1delta/mek1delta mre11-D65N(aa)/mre11-D65N(aa)
• mek1delta/mek1delta mre11-D65N(aa)/mre11-D65N(aa) rad50S(K81I aa)/rad50S(K81I aa)

FYPO:0003181 - abolished meiotic DNA double-strand break formation

References:

• PMID:18378696

Genes:

• ctp1 (SPCC338.08)
• rec12 (SPAC17A5.11)

Genotypes:

• ctp1delta rec12delta

FYPO:0003844 - abolished mitotic chromosome condensation

References:

• PMID:21540296

Genes:

• cnd2 (SPCC306.03c)

Genotypes:

• cnd2-1(A114T aa) cnd2-3E(S5E,S41E,S52E aa)[Overexpression]

FYPO:0006728 - abolished mitotic DNA replication initiation

References:

• PMID:22718908
• PMID:7883794

Genes:

• cdc10 (SPBC336.12c)
• pol1 (SPAC3H5.06c)
• rum1 (SPBC32F12.09)
• spp2 (SPBC17D11.06)

Genotypes:

• cdc10-129(T429A aa) rum1delta
• pol1-AID[Knockdown] spp2-AID[Knockdown]

FYPO:0008336 - abolished mRNA poly(A) tail uridylation

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)
• cid16 (SPAC17H9.01)

Genotypes:

• cid16delta cid1delta

FYPO:0003602 - abolished mRNA splicing, via spliceosome

References:

• PMID:26730850

Genes:

• ppk8 (SPAC22G7.08)
• prp4 (SPCC777.14)
• res1 (SPBC725.16)

Genotypes:

• ppk8'-1(G67C nt) ppk8+(wild type) prp4-as2(F238A aa)
• ppk8'-3(A476T nt) ppk8+(wild type) prp4-as2(F238A aa)
• prp4-as2(F238A aa) res1'-2A(T229A,T230A,A341T nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-2C(T229A,T230A,T339G nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-3(G227C,T229A,T230A nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-8(T979A nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-B(A340T nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-D(C338G nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-E(C342G nt) res1+(wild type)

FYPO:0005038 - abolished phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during nitrogen starvation

References:

• PMID:22144909

Genes:

• lsk1 (SPAC2F3.15)
• wis1 (SPBC409.07c)

Genotypes:

• lsk1delta wis1+(wild type)[Overexpression]

FYPO:0002044 - abolished premeiotic DNA replication

References:

• PMID:3870979

Genes:

• mei2 (SPAC27D7.03c)
• pat1 (SPBC19C2.05)

Genotypes:

• mei2-16(unknown)/mei2-16(unknown) pat1-114(V155G,P219S,L291F aa)/pat1-114(V155G,P219S,L291F aa)

FYPO:0004800 - abolished premeiotic DNA replication during azygotic meiotic cell cycle

References:

• PMID:25891897

Genes:

• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)
• crs1 (SPBC2G2.09c)
• puc1 (SPBC19F5.01c)
• rem1 (SPBC16E9.17c)

Genotypes:

• cig1delta cig2delta crs1delta puc1delta rem1delta
• cig1delta cig2delta puc1delta rem1delta

FYPO:0004486 - abolished protein deacetylation during vegetative growth

References:

• PMID:21979813

Genes:

• clr6 (SPBC36.05c)
• psm3 (SPAC10F6.09c)

Genotypes:

• clr6+(wild type)[Overexpression] psm3-K106N(aa)

FYPO:0005676 - abolished protein deubiquitination following cellular response to methyl methanesulfonate during vegetative growth

References:

• PMID:27151298

Genes:

• ubp12 (SPCC1494.05c)
• ubp15 (SPBC713.02c)
• ubp16 (SPCC1682.12c)

Genotypes:

• ubp12-NES ubp15-NES ubp16delta

FYPO:0003728 - abolished protein galactosylation during vegetative growth

References:

• PMID:19942659

Genes:

• gal10 (SPBPB2B2.12c)
• gal7 (SPBPB2B2.10c)
• uge1 (SPBC365.14c)

Genotypes:

• gal10delta gal7delta uge1delta
• gal10delta uge1delta

FYPO:0003228 - abolished protein oxidation during cellular response to hydrogen peroxide

References:

• PMID:24268782
• PMID:33225241

Genes:

• hsp104 (SPBC16D10.08c)
• mas5 (SPBC1734.11)
• pap1 (SPAC1783.07c)
• tpx1 (SPCC576.03c)
• trx1 (SPAC7D4.07c)

Genotypes:

• hsp104delta mas5delta
• mas5delta pap1delta
• tpx1delta trx1delta

FYPO:0002678 - abolished protein phosphorylation

References:

• PMID:25520186
• PMID:36481249

Genes:

• cut14 (SPBP4H10.06c)
• cut3 (SPBC146.03c)
• tor2 (SPBC216.07c)
• wat1 (SPBC21B10.05c)

Genotypes:

• cut14-K38T(aa) cut3-K161I(aa)
• tor2-L2048S(aa) wat1-17(C233Y aa)

FYPO:0005478 - abolished protein phosphorylation during cellular response to arsenite ion

References:

• PMID:31911490

Genes:

• pmk1 (SPBC119.08)
• sty1 (SPAC24B11.06c)

Genotypes:

• pmk1delta sty1delta

FYPO:0005616 - abolished protein phosphorylation during cellular response to bleomycin

References:

• PMID:18378696

Genes:

• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)

Genotypes:

• rad3delta tel1delta

FYPO:0002898 - abolished protein phosphorylation during cellular response to DNA damage

References:

• PMID:23211746

Genes:

• exo1 (SPBC29A10.05)
• rad2 (SPAC3G6.06c)

Genotypes:

• exo1+(wild type)[Knockdown] rad2delta

FYPO:0002130 - abolished protein phosphorylation during cellular response to heat

References:

• PMID:20547592
• PMID:31911490

Genes:

• gcn2 (SPBC36B7.09)
• hri1 (SPAC20G4.03c)
• pmk1 (SPBC119.08)
• sty1 (SPAC24B11.06c)

Genotypes:

• gcn2delta hri1delta
• pmk1delta sty1delta

FYPO:0006232 - abolished protein phosphorylation during cellular response to hydrogen peroxide

References:

• PMID:16278445
• PMID:22918952

Genes:

• cdc2 (SPBC11B10.09)
• gcn2 (SPBC36B7.09)
• hri2 (SPAC222.07c)
• pmk1 (SPBC119.08)
• rad3 (SPBC216.05)
• sty1 (SPAC24B11.06c)

Genotypes:

• cdc2-as(F84G aa) pmk1delta rad3delta
• gcn2delta hri2delta
• gcn2delta hri2delta sty1-1(unknown)

FYPO:0004550 - abolished protein phosphorylation during cellular response to hydroxyurea

References:

• PMID:10683155
• PMID:14585996
• PMID:15155581
• PMID:15173168
• PMID:16618806
• PMID:21561865
• PMID:22918952
• PMID:26746798

Genes:

• cdc2 (SPBC11B10.09)
• cdc20 (SPBC25H2.13c)
• cds1 (SPCC18B5.11c)
• mrc1 (SPAC694.06c)
• pmk1 (SPBC119.08)
• rad17 (SPAC14C4.13)
• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)

Genotypes:

• cdc2-as(F84G aa) pmk1delta rad3delta
• cdc20-M10(unknown) rad17-d14(R411W aa)
• cdc20-M10(unknown) rad17delta
• cds1-D312E(aa) mrc1delta
• cds1-D312E(aa) rad3delta
• rad3-D2249E(aa) tel1delta
• rad3delta tel1delta

FYPO:0002471 - abolished protein phosphorylation during cellular response to ionizing radiation

References:

• PMID:15155581
• PMID:29851556

Genes:

• cds1 (SPCC18B5.11c)
• chk1 (SPCC1259.13)
• mre11 (SPAC13C5.07)
• nbs1 (SPBC6B1.09c)
• rad3 (SPBC216.05)
• rad9 (SPAC664.07c)
• tel1 (SPCC23B6.03c)

Genotypes:

• cds1delta rad9-T412A(aa)
• chk1delta rad9-T412A(aa)
• mre11delta rad3delta
• mre11delta rad3delta tel1+(wild type)[Overexpression]
• nbs1delta rad3delta
• rad3-D2249E(aa) tel1delta

FYPO:0006709 - abolished protein phosphorylation during cellular response to salt stress

References:

• PMID:20164182

Genes:

• pck2 (SPBC12D12.04c)
• rga4 (SPBC28E12.03)
• rho2 (SPAC16.01)

Genotypes:

• pck2delta rga4delta
• rga4delta rho2delta

FYPO:0006708 - abolished protein phosphorylation during glucose starvation

References:

• PMID:31911490

Genes:

• pmk1 (SPBC119.08)
• sty1 (SPAC24B11.06c)

Genotypes:

• pmk1delta sty1delta

FYPO:0008412 - abolished protein phosphorylation during mating

References:

• PMID:39705284

Genes:

• rps601 (SPAC13G6.07c)
• rps602 (SPAPB1E7.12)

Genotypes:

• rps601delta rps602-S235A,S236A(aa)

FYPO:0004939 - abolished protein phosphorylation during meiotic cell cycle

References:

• PMID:17804800
• PMID:20383139

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• mei4 (SPBC32H8.11)
• mik1 (SPBC660.14)
• wee1 (SPCC18B5.03)

Genotypes:

• hhp1-as(M84G aa) hhp2delta
• mei4delta mik1delta wee1-50(G850E aa)
• mik1delta wee1-50(G850E aa)

FYPO:0004262 - abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation

References:

• PMID:21098122

Genes:

• crb2 (SPBC342.05)
• ctp1 (SPCC338.08)
• hta1 (SPCC622.08c)
• hta2 (SPAC19G12.06c)
• hus1 (SPAC20G4.04c)
• mre11 (SPAC13C5.07)
• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)

Genotypes:

• crb2-T215A(aa) ctp1delta rad3delta
• crb2delta ctp1delta rad3delta
• ctp1delta hta1-S129A(aa) hta2-S128A(aa) rad3delta
• ctp1delta hus1delta
• ctp1delta hus1delta rad3delta
• ctp1delta mre11-D65N(aa) rad3delta
• ctp1delta mre11-H134S(aa) rad3delta
• ctp1delta mre11delta rad3delta
• ctp1delta rad3delta tel1delta
• hus1delta rad3delta
• mre11-D65N(aa) rad3delta
• mre11-H134S(aa) rad3delta
• mre11delta rad3delta

FYPO:0002033 - abolished protein phosphorylation during vegetative growth

References:

• PMID:11781565
• PMID:12093738
• PMID:19965387
• PMID:20144990
• PMID:22976295
• PMID:23394829
• PMID:23671279
• PMID:39010328
• PMID:7626804

Genes:

• cdc10 (SPBC336.12c)
• cdc16 (SPAC6F6.08c)
• cdc2 (SPBC11B10.09)
• cdc3 (SPAC4A8.15c)
• cig2 (SPAPB2B4.03)
• gcn2 (SPBC36B7.09)
• hri2 (SPAC222.07c)
• hta1 (SPCC622.08c)
• hta2 (SPAC19G12.06c)
• mik1 (SPBC660.14)
• nak1 (SPBC17F3.02)
• pib2 (SPBC9B6.03)
• psk1 (SPCC4G3.08)
• res1 (SPBC725.16)
• rps601 (SPAC13G6.07c)
• rps602 (SPAPB1E7.12)
• tor2 (SPBC216.07c)
• tsc2 (SPAC630.13c)
• wee1 (SPCC18B5.03)

Genotypes:

• cdc10-129(T429A aa) cig2delta res1+(wild type)[Overexpression]
• cdc10-129(T429A aa) cig2delta res1-S130A(aa)[Overexpression]
• cdc10-129(T429A aa) res1-S130A(aa)[Overexpression]
• cdc16-116(R105C aa) cdc3-124(E43K aa) nak1-5A(S479A,S491A,S501A,S533A,S561A aa)
• cdc2-T14A(aa) wee1+(wild type)[Overexpression]
• gcn2delta hri2delta
• hta1-S121A(S122A aa) hta2-S121A(S122A aa)
• mik1delta wee1-50(G850E aa)
• pib2deltatail(280-293 Δaa) tor2-13(C2163R,I2280V,Q2305L aa)
• psk1delta tor2-L1310P(aa)
• psk1delta tsc2delta
• rps601delta rps602-S235A,S236A(aa)

FYPO:0005183 - abolished protein polyubiquitination during cellular response to UV

References:

• PMID:20452294

Genes:

• pcn1 (SPBC16D10.09)
• rad8 (SPAC13G6.01c)
• rhp18 (SPBC1734.06)

Genotypes:

• HA-ubi1-K63R-pcn1-K164R(pcn1delta::HA-ubi1-K63R-pcn1-K164R) pcn1-K164R(aa)
• HA-ubi1-K63R-pcn1(pcn1delta::HA-ubi1-K36R-pcn1) pcn1-K164R(aa)
• HA-ubi1-pcn1-K164R(pcn1delta::HA-ubi1-pcn1-K164R) pcn1-K164R(aa)
• HA-ubi1-pcn1-K164R(pcn1delta::HA-ubi1-pcn1-K164R) rad8delta
• HA-ubi1-pcn1-K164R(pcn1delta::HA-ubi1-pcn1-K164R) rhp18delta
• HA-ubi1-pcn1(pcn1delta::HA-ubi1-pcn1) pcn1-K164R(aa)
• HA-ubi1-pcn1(pcn1delta::HA-ubi1-pcn1) rad8delta
• HA-ubi1-pcn1(pcn1delta::HA-ubi1-pcn1) rhp18delta

FYPO:0005928 - abolished protein polyubiquitination during vegetative growth

References:

• PMID:28366744

Genes:

• apc15 (SPBC83.04)
• mad3 (SPCC1795.01c)

Genotypes:

• apc15delta mad3-KEN2-AAA(K271A,E272A,N273A aa)

FYPO:0006375 - abolished protein processing during nitrogen starvation

References:

• PMID:25803873

Genes:

• isp6 (SPAC4A8.04)
• psp3 (SPAC1006.01)

Genotypes:

• isp6delta psp3delta

FYPO:0001669 - abolished protein processing during vegetative growth

References:

• PMID:21153812
• PMID:25803873
• PMID:27655872
• PMID:28947618
• PMID:33788833

Genes:

• dsc1 (SPBC947.10)
• isp6 (SPAC4A8.04)
• psp3 (SPAC1006.01)
• sre2 (SPBC354.05c)
• ubp15 (SPBC713.02c)
• ubp5 (SPCC188.08c)

Genotypes:

• dsc1delta sre2-MS+K743R(1-422,K743R aa)
• isp6delta psp3delta
• ubp15delta ubp5delta

FYPO:0000912 - abolished protein ubiquitination during vegetative growth

References:

• PMID:29742018

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)

Genotypes:

• hhp1-K40R(aa) hhp2-K41R(aa)
• hhp1-R261E(aa) hhp2delta
• hhp1-R272E,K273E(aa) hhp2delta
• hhp1delta hhp2delta

FYPO:0002879 - abolished transcription during glucose starvation

References:

• PMID:28674280

Genes:

• gcn5 (SPAC1952.05)
• hrp3 (SPAC3G6.01)
• snf22 (SPCC1620.14c)

Genotypes:

• gcn5delta hrp3delta
• gcn5delta snf22delta
• hrp3delta snf22delta

FYPO:0006148 - abolished transcription during nitrogen starvation

References:

• PMID:12664134

Genes:

• cgs1 (SPAC8C9.03)
• mei3 (SPBC119.04)

Genotypes:

• cgs1::ura4(disruption)[Null] mei3+(wild type)[Overexpression]
• cgs1::ura4(disruption)[Null] mei3-RA3(S29A,T30A,S31A aa)[Overexpression]

FYPO:0001768 - abolished tRNA-Asp C38 methylation

References:

• PMID:26424849

Genes:

• qtr1 (SPAC1687.19c)
• qtr2 (SPAC2F3.13c)

Genotypes:

• qtr1delta qtr2delta

FYPO:0007296 - abolished UDP-galactose biosynthetic process

References:

• PMID:19942659

Genes:

• gal10 (SPBPB2B2.12c)
• gal7 (SPBPB2B2.10c)
• uge1 (SPBC365.14c)

Genotypes:

• gal10delta gal7delta uge1delta

FYPO:0003467 - altered splice site specificity

References:

• PMID:34706246

Genes:

• prp2 (SPBC146.07)
• rhb1 (SPBC428.16c)

Genotypes:

• prp2-C387Y(aa) rhb1-SWAP(rhb1 minigene in which the positions of the two introns are interchanged)[Ectopic]

FYPO:0003585 - decreased anaphase-promoting complex-dependent protein catabolic process

References:

• PMID:12477395

Genes:

• apc14 (SPAC27D7.05c)
• apc15 (SPBC83.04)

Genotypes:

• apc14delta apc15delta

FYPO:0003455 - decreased arginine catabolic process to proline

References:

• PMID:25720772

Genes:

• arg3 (SPAC4G9.10)
• aru1 (SPAC3H1.07)
• car1 (SPBP26C9.02c)
• lys3 (SPAC227.18)

Genotypes:

• arg3delta aru1delta car1delta lys3delta

FYPO:0000342 - decreased cellular respiration

References:

• PMID:38692277

Genes:

• mic60 (SPBC3E7.05c)
• mmc1 (SPAC1610.04)

Genotypes:

• mic60delta mmc1delta

FYPO:0006731 - decreased CMG complex progression from replication origin

References:

• PMID:22718908

Genes:

• cdc20 (SPBC25H2.13c)
• pol1 (SPAC3H5.06c)
• spp2 (SPBC17D11.06)

Genotypes:

• cdc20-ct1deltaN(1-1217,Y1520N,D1625G,L1726S,S1904P aa) pol1-AID[Knockdown] spp2-AID[Knockdown]
• pol1-AID[Knockdown] spp2-AID[Knockdown]

FYPO:0006686 - decreased DNA double-strand break processing

References:

• PMID:33723569

Genes:

• exo1 (SPBC29A10.05)
• mst1 (SPAC637.12c)

Genotypes:

• exo1delta mst1-L344S(aa)

FYPO:0006687 - decreased DNA double-strand break processing during double-strand break repair via homologous recombination

References:

• PMID:21931565

Genes:

• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• mre11 (SPAC13C5.07)
• pku80 (SPBC543.03c)

Genotypes:

• ctp1delta exo1delta pku80delta
• ctp1delta pku80delta
• mre11delta pku80delta

FYPO:0006318 - decreased DNA resection during replication fork processing

References:

• PMID:29215009

Genes:

• exo1 (SPBC29A10.05)
• rqh1 (SPAC2G11.12)

Genotypes:

• exo1delta rqh1delta

FYPO:0003660 - decreased double-strand break repair during vegetative growth

References:

• PMID:39387272

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)

Genotypes:

• hhp1-as(M84G aa) hhp2-as(M85G aa)

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

• PMID:12628934
• PMID:25165823
• PMID:27098497
• PMID:27325741
• PMID:38718864
• PMID:39387272

Genes:

• chk1 (SPCC1259.13)
• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• fbh1 (SPBC336.01)
• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• htb1 (SPCC622.09)
• pku70 (SPCC126.02c)
• rad51 (SPAC644.14c)
• rad55 (SPAC3C7.03c)
• rad57 (SPAC20H4.07)
• shf1 (SPAC22F8.12c)
• spd1 (SPAC29B12.03)
• ubp8 (SPAC13A11.04c)
• wdr70 (SPAC343.17c)

Genotypes:

• chk1delta ctp1-25(G187*)
• chk1delta ctp1-6(D250*)
• exo1+(wild type)[Overexpression] spd1delta wdr70delta
• exo1delta spd1delta
• exo1delta spd1delta wdr70delta
• fbh1delta rad51delta
• fbh1delta rad57delta
• hhp1-as(M84G aa) hhp2-as(M85G aa)
• htb1-G52D(G53D aa) shf1delta ubp8delta
• htb1-G52D(G53D aa) ubp8delta
• htb1-P102L(P103L aa) shf1delta ubp8delta
• htb1-P102L(P103L aa) ubp8delta
• pku70delta rad55delta
• rad51delta rad55delta
• spd1delta wdr70delta

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

• PMID:28292918
• PMID:39387272

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• lig4 (SPCC1183.05c)
• mre11 (SPAC13C5.07)

Genotypes:

• hhp1-as(M84G aa) hhp2-as(M85G aa)
• lig4delta mre11delta

FYPO:0000432 - decreased fermentation

References:

• PMID:15040954

Genes:

• adh1 (SPCC13B11.01)
• adh4 (SPAC5H10.06c)

Genotypes:

• adh1delta adh4delta

FYPO:0005660 - decreased frequency of meiotic crossover associated with gene conversion

References:

• PMID:25414342

Genes:

• dmc1 (SPAC8E11.03c)
• fml1 (SPAC9.05)
• mus81 (SPCC4G3.05c)
• rad55 (SPAC3C7.03c)
• rdl1 (SPAC17H9.03c)
• rlp1 (SPBC1685.11)
• sfr1 (SPBC28F2.07)
• sws1 (SPBC11B10.06)

Genotypes:

• dmc1delta fml1delta rlp1delta
• dmc1delta mus81delta
• dmc1delta rdl1delta
• dmc1delta rlp1delta
• dmc1delta sfr1delta
• mus81delta rad55delta
• mus81delta rdl1delta
• mus81delta rlp1delta
• mus81delta sfr1delta
• rad55delta rlp1delta
• rdl1delta rlp1delta
• rdl1delta rlp1delta sws1delta
• rlp1delta sfr1delta

FYPO:0006921 - decreased gene conversion at mitotic DNA replication fork barriers

References:

• PMID:31149897

Genes:

• elg1 (SPBC947.11c)
• rad51 (SPAC644.14c)
• srs2 (SPAC4H3.05)

Genotypes:

• elg1delta rad51delta
• elg1delta srs2delta

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

• PMID:17724078
• PMID:19798055
• PMID:27697832
• PMID:34292936

Genes:

• cdc27 (SPBC1734.02c)
• exo1 (SPBC29A10.05)
• lig4 (SPCC1183.05c)
• mus81 (SPCC4G3.05c)
• pcn1 (SPBC16D10.09)
• pku70 (SPCC126.02c)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rad55 (SPAC3C7.03c)
• rqh1 (SPAC2G11.12)

Genotypes:

• cdc27-D1(160-372 Δaa) rad51delta
• exo1delta rad55delta
• exo1delta rqh1delta
• lig4delta rad55delta
• mus81delta rad51delta
• pcn1-K107R(aa) rad51delta
• pku70delta rad55delta
• rad51delta rad52-R45K(aa)

FYPO:0003081 - decreased genetic imprinting at mating-type locus

References:

• PMID:23260662

Genes:

• clr4 (SPBC428.08c)
• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)
• set1 (SPCC306.04c)
• set6 (SPBP8B7.07c)
• set9 (SPCC4B3.12)

Genotypes:

• clr4delta lsd1-E918(E918*)
• lsd1-E918(E918*) set1delta
• lsd1-E918(E918*) set6delta
• lsd1-E918(E918*) set9delta
• lsd1-ao(K603A,K604A aa) lsd2-ao(K823A,K824A aa)

FYPO:0008378 - decreased histone H2A phosphorylation during cellular response to camptothecin

References:

• PMID:38971312

Genes:

• dis2 (SPBC776.02c)
• tor1 (SPBC30D10.10c)

Genotypes:

• dis2delta tor1delta

FYPO:0004867 - decreased histone H2A phosphorylation during cellular response to ionizing radiation

References:

• PMID:21098122
• PMID:26368543
• PMID:29851556

Genes:

• hus1 (SPAC20G4.04c)
• mre11 (SPAC13C5.07)
• nbs1 (SPBC6B1.09c)
• rad3 (SPBC216.05)
• rad50 (SPAC1556.01c)
• rfc3 (SPAC27E2.10c)
• tel1 (SPCC23B6.03c)

Genotypes:

• hus1delta tel1delta
• mre11delta rad3delta
• mre11delta rad3delta tel1+(wild type)[Overexpression]
• nbs1-10(DD603NN aa) rad3delta
• nbs1-9(F611E,F613E aa) rad3delta
• nbs1-c60-delta(554-613 Δaa) rad3(1-1476)(1477-2386 Δaa)
• nbs1-c60-delta(554-613 Δaa) rad3delta
• nbs1delta rad3delta
• rad3delta rad50-I1192W(aa) tel1+(wild type)[Overexpression]
• rfc3-1(R216W aa) tel1delta

FYPO:0008379 - decreased histone H2A phosphorylation during nitrogen starvation

References:

• PMID:38971312

Genes:

• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)
• tor1 (SPBC30D10.10c)

Genotypes:

• rad3delta tor1delta
• tel1delta tor1delta

FYPO:0002598 - decreased histone H2A phosphorylation during vegetative growth

References:

• PMID:32341083

Genes:

• mcm4 (SPCC16A11.17)
• mus81 (SPCC4G3.05c)

Genotypes:

• cdc21-M68(unknown) mus81delta

FYPO:0010055 - decreased histone H2A-S121 phosphorylation at subtelomere during vegetative growth

References:

• PMID:40520116

Genes:

• nts1 (SPCC24B10.19c)
• set2 (SPAC29B12.02c)

Genotypes:

• nts1delta set2delta

FYPO:0005608 - decreased histone H2B-K119 ubiquitination at double-strand break site during vegetative growth

References:

• PMID:27098497

Genes:

• exo1 (SPBC29A10.05)
• rqh1 (SPAC2G11.12)
• spd1 (SPAC29B12.03)
• wdr70 (SPAC343.17c)

Genotypes:

• exo1delta rqh1delta spd1delta
• spd1delta wdr70-DWD(W325A,D326A aa)
• spd1delta wdr70delta

FYPO:0007386 - decreased histone H2B-K119 ubiquitination during vegetative growth

References:

• PMID:38718864

Genes:

• htb1 (SPCC622.09)
• sgf11 (SPAC57A10.14)

Genotypes:

• htb1-P102L(P103L aa) sgf11delta

FYPO:0000967 - decreased histone H3-K14 acetylation at centromere outer repeat during vegetative growth

References:

• PMID:30573453

Genes:

• gcn5 (SPAC1952.05)
• sir2 (SPBC16D10.07c)

Genotypes:

• gcn5delta sir2delta

FYPO:0001458 - decreased histone H3-K14 acetylation during vegetative growth

References:

• PMID:39094565

Genes:

• epe1 (SPCC622.16c)
• gcn5 (SPAC1952.05)
• mst2 (SPAC17G8.13c)

Genotypes:

• epe1-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron) gcn5delta mst2delta
• epe1-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron) mst2delta

FYPO:0006857 - decreased histone H3-K37 methylation

References:

• PMID:30773398

Genes:

• set2 (SPAC29B12.02c)
• set7 (SPCC297.04c)

Genotypes:

• set2delta set7delta

FYPO:0008256 - decreased histone H3-K4 acetylation at LTR during vegetative growth

References:

• PMID:25356590

Genes:

• mst1 (SPAC637.12c)
• set1 (SPCC306.04c)

Genotypes:

• mst1-ts(unknown) set1-F(set1-3xFLAG)

FYPO:0008255 - decreased histone H3-K4 acetylation at protein coding gene during vegetative growth

References:

• PMID:25356590

Genes:

• mst1 (SPAC637.12c)
• set1 (SPCC306.04c)

Genotypes:

• mst1-ts(unknown) set1-F(set1-3xFLAG)

FYPO:0004240 - decreased histone H3-K56 acetylation during vegetative growth

References:

• PMID:39878217

Genes:

• asf1 (SPCC663.05c)
• djc9 (SPAC1071.09c)
• rtt109 (SPBC342.06c)

Genotypes:

• asf1delta djc9delta
• asf1delta djc9delta rtt109delta
• djc9delta rtt109delta

FYPO:0007217 - decreased histone H3-K9 acetylation at protein coding gene during vegetative growth

References:

• PMID:33533152

Genes:

• ell1 (SPBP23A10.14c)
• epe1 (SPCC622.16c)

Genotypes:

• ell1delta epe1(1-402)(403-948 Δaa)[Overexpression]

FYPO:0000877 - decreased histone H3-K9 dimethylation at centromere during vegetative growth

References:

• PMID:19362535
• PMID:24013500

Genes:

• chp1 (SPAC18G6.02c)
• clr1 (SPBC2D10.17)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• dcr1 (SPCC188.13c)
• seb1 (SPAC222.09)

Genotypes:

• chp1-E23V(aa) clr4delta->clr4+(reintroduced clr4+)
• chp1-N59A(aa) clr4delta->clr4+(reintroduced clr4+)
• chp1-V24M(aa) clr4delta->clr4+(reintroduced clr4+)
• clr1delta seb1-1(A45G,T132A,G226A,T1384C,T1450A,A1514G,A1760G nt)
• clr3delta dcr1-R1R2(unknown)
• clr3delta seb1-1(A45G,T132A,G226A,T1384C,T1450A,A1514G,A1760G nt)

FYPO:0000878 - decreased histone H3-K9 dimethylation at centromere inner repeat during vegetative growth

References:

• PMID:30652128

Genes:

• ago1 (SPCC736.11)
• mlo3 (SPBC1D7.04)

Genotypes:

• ago1delta mlo3delta

FYPO:0000888 - decreased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

• PMID:20178743
• PMID:21215368
• PMID:25245948
• PMID:26438724
• PMID:26744419
• PMID:27334362
• PMID:27538348
• PMID:28541282
• PMID:31822915
• PMID:32295063

Genes:

• ago1 (SPCC736.11)
• cid12 (SPCC663.12)
• cid14 (SPAC12G12.13c)
• clr3 (SPBC800.03)
• dcr1 (SPCC188.13c)
• ddb1 (SPAC17H9.10c)
• dsh1 (SPBC582.04c)
• epe1 (SPCC622.16c)
• lem2 (SPAC18G6.10)
• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)
• mkt1 (SPAC139.01c)
• raf1 (SPCC613.12c)
• rdp1 (SPAC6F12.09)
• set3 (SPAC22E12.11c)
• sir2 (SPBC16D10.07c)
• spd1 (SPAC29B12.03)
• swi6 (SPAC664.01c)
• tas3 (SPBC83.03c)
• tls1 (SPAC1D4.01)

Genotypes:

• ago1-D580A(aa) dcr1delta
• ago1delta lsd1-ao(K603A,K604A aa)
• ago1delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• ago1delta lsd2-ao(K823A,K824A aa)
• ago1delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
• ago1delta tls1delta
• cid12delta cid14delta
• cid14delta dcr1delta
• clr3delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• clr3delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
• dcr1delta lem2delta
• dcr1delta rdp1delta
• dcr1delta tas3delta
• ddb1delta spd1delta
• dsh1delta lem2delta
• epe1delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• epe1delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
• lsd1-deltaHMG(841-1000 Δaa)[Knockdown] sir2delta
• lsd2-deltaC(1165-1235 Δaa)[Knockdown] sir2delta
• mkt1delta sir2delta
• raf1+(wild type)[Overexpression] set3delta
• swi6delta tas3-L479E(aa)

FYPO:0007642 - decreased histone H3-K9 dimethylation at rDNA during G0

References:

• PMID:27738016

Genes:

• clr4 (SPBC428.08c)
• dcr1 (SPCC188.13c)

Genotypes:

• clr4delta dcr1delta

FYPO:0002355 - decreased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

References:

• PMID:22683269
• PMID:22895252
• PMID:32295063
• PMID:40923761

Genes:

• ago1 (SPCC736.11)
• atf1 (SPBC29B5.01)
• cid14 (SPAC12G12.13c)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• dcr1 (SPCC188.13c)
• dsh1 (SPBC582.04c)
• epe1 (SPCC622.16c)
• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)
• pcr1 (SPAC21E11.03c)
• sir2 (SPBC16D10.07c)
• swi6 (SPAC664.01c)

Genotypes:

• ago1delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• ago1delta lsd2-ao(K823A,K824A aa)
• ago1delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
• atf1delta clr4-IDR-Mut1(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q aa)
• atf1delta clr4-IDR-Mut2(K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
• atf1delta dcr1delta
• atf1delta dsh1delta
• cid14delta swi6delta
• clr3delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• clr3delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
• clr4-IDR-Mut1(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q aa) pcr1delta
• clr4-IDR-Mut2(K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa) pcr1delta
• epe1delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• epe1delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
• lsd1-deltaHMG(841-1000 Δaa)[Knockdown] sir2delta
• lsd2-deltaC(1165-1235 Δaa)[Knockdown] sir2delta

FYPO:0004137 - decreased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

• PMID:21215368
• PMID:28404620
• PMID:32295063

Genes:

• ago1 (SPCC736.11)
• clr3 (SPBC800.03)
• dcr1 (SPCC188.13c)
• ddb1 (SPAC17H9.10c)
• epe1 (SPCC622.16c)
• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)
• mot2 (SPAC16C9.04c)
• sir2 (SPBC16D10.07c)
• spd1 (SPAC29B12.03)

Genotypes:

• ago1delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• clr3delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• clr3delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
• dcr1delta mot2delta
• ddb1delta spd1delta
• epe1delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
• epe1delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
• lsd1-deltaHMG(841-1000 Δaa)[Knockdown] sir2delta
• lsd2-deltaC(1165-1235 Δaa)[Knockdown] sir2delta

FYPO:0003096 - decreased histone H3-K9 methylation at centromere outer repeat during vegetative growth

References:

• PMID:11283354
• PMID:15372076
• PMID:21892171

Genes:

• ago1 (SPCC736.11)
• chp1 (SPAC18G6.02c)
• cid14 (SPAC12G12.13c)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• rrp6 (SPAC1F3.01)
• swi6 (SPAC664.01c)
• tfs1 (SPAC20H4.03c)

Genotypes:

• ago1delta cid14delta
• ago1delta clr3delta
• ago1delta clr3delta tfs1delta
• ago1delta rrp6delta
• chp1delta swi6delta
• clr3-375(unknown) clr4-R320H(aa)

FYPO:0003231 - decreased histone H3-K9 methylation at heterochromatin domain during vegetative growth

References:

• PMID:24210919

Genes:

• cwf10 (SPBC215.12)
• nrl1 (SPBC20F10.05)
• rmn1 (SPBC902.04)
• rrp6 (SPAC1F3.01)

Genotypes:

• cwf10-1(C324Y aa) rrp6delta
• nrl1delta rrp6delta
• rmn1delta rrp6delta

FYPO:0003571 - decreased histone H3-K9 methylation at silent mating-type cassette during vegetative growth

References:

• PMID:15218150
• PMID:15475954
• PMID:19136623

Genes:

• ago1 (SPCC736.11)
• atf1 (SPBC29B5.01)
• chp1 (SPAC18G6.02c)
• ckb1 (SPAC1851.03)
• dcr1 (SPCC188.13c)
• pcr1 (SPAC21E11.03c)
• rdp1 (SPAC6F12.09)
• tas3 (SPBC83.03c)

Genotypes:

• ago1delta atf1delta
• ago1delta pcr1delta
• atf1delta dcr1delta
• atf1delta rdp1delta
• chp1delta pcr1delta
• ckb1delta dcr1delta
• dcr1delta pcr1delta
• pcr1delta rdp1delta
• pcr1delta tas3delta

FYPO:0003572 - decreased histone H3-K9 methylation at subtelomeric heterochromatin during vegetative growth

References:

• PMID:28404620

Genes:

• ccr4 (SPCC31H12.08c)
• dcr1 (SPCC188.13c)

Genotypes:

• ccr4delta dcr1delta

FYPO:0008185 - decreased histone H3-K9 trimethylation at centromere central core during vegetative growth

References:

• PMID:38479839

Genes:

• dpb4 (SPBC3D6.09)
• mcm2 (SPBC4.04c)
• pob3 (SPBC609.05)

Genotypes:

• dpb4delta mcm2-2a(Y80A,Y89A aa) pob3delta

FYPO:0000890 - decreased histone H3-K9 trimethylation at centromere outer repeat during vegetative growth

References:

• PMID:27648579
• PMID:38479839
• PMID:41316862

Genes:

• clr4 (SPBC428.08c)
• ctu2 (SPBC19C2.13c)
• dcr1 (SPCC188.13c)
• dpb4 (SPBC3D6.09)
• elp1 (SPBC36.07)
• elp3 (SPAC29A4.20)
• epe1 (SPCC622.16c)
• hht1 (SPAC1834.04)
• hht3 (SPBC1105.11c)
• mcm2 (SPBC4.04c)
• rpb2 (SPAC23G3.01)

Genotypes:

• clr4+(wild type)[Overexpression] hht3-K9M(K10M aa)
• ctu2delta rpb2-m203(N44Y aa)
• dcr1delta dpb4delta
• dcr1delta mcm2-2a(Y80A,Y89A aa)
• dpb4delta mcm2-2a(Y80A,Y89A aa)
• elp1delta elp3delta rpb2-m203(N44Y aa)
• elp3-CC(C106A,C109A aa) rpb2-m203(N44Y aa)
• elp3delta rpb2-m203(N44Y aa)
• epe1delta hht3-K9M(K10M aa)
• hht1+(wild type)[Overexpression] hht3-K9M(K10M aa)
• hht3+(wild type)[Overexpression] hht3-K9M(K10M aa)

FYPO:0005845 - decreased histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth

References:

• PMID:31883795
• PMID:39094566
• PMID:39096900

Genes:

• ago1 (SPCC736.11)
• amo1 (SPBC15D4.10c)
• clr3 (SPBC800.03)
• mcm2 (SPBC4.04c)
• mrc1 (SPAC694.06c)
• mst2 (SPAC17G8.13c)
• pob3 (SPBC609.05)
• rix1 (SPCC4G3.18)
• rsc1 (SPBC4B4.03)
• snf22 (SPCC1620.14c)
• snf5 (SPAC2F7.08c)
• snf59 (SPBC26H8.09c)

Genotypes:

• ago1delta amo1delta
• ago1delta pob3delta
• ago1delta rix1-E414K(aa)
• clr3-735(D232N aa) rsc1delta
• clr3-735(D232N aa) rsc1delta snf22delta
• clr3-735(D232N aa) snf22delta
• clr3delta rsc1delta
• clr3delta snf22delta
• mcm2-2a(Y80A,Y89A aa) mrc1delta
• mst2-CDx2(Chromodomain fusion) snf22delta
• snf22delta snf5-CDx2(Chromodomain fusion)
• snf22delta snf59-CDx2(Chromodomain fusion)

FYPO:0005014 - decreased histone H4-K12 acetylation during vegetative growth

References:

• PMID:20404084

Genes:

• clr6 (SPBC36.05c)
• oca2 (SPCC1020.10)

Genotypes:

• clr6-1(G269D aa) oca2delta

FYPO:0005533 - decreased histone H4-K16 acetylation at boundary element IRC1L during vegetative growth

References:

• PMID:25972440

Genes:

• leo1 (SPBC13E7.08c)
• swi6 (SPAC664.01c)

Genotypes:

• leo1delta swi6delta

FYPO:0002485 - decreased intergenic meiotic recombination

References:

• PMID:18514516
• PMID:25414342
• PMID:25579976
• PMID:25993311
• PMID:30640914

Genes:

• cig1 (SPCC4E9.02)
• crs1 (SPBC2G2.09c)
• dmc1 (SPAC8E11.03c)
• fml1 (SPAC9.05)
• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• mus81 (SPCC4G3.05c)
• rad55 (SPAC3C7.03c)
• rdl1 (SPAC17H9.03c)
• rec10 (SPAC25G10.04c)
• rec25 (SPAC17A5.18c)
• rec27 (SPBC577.05c)
• rec8 (SPBC29A10.14)
• rlp1 (SPBC1685.11)
• rqh1 (SPAC2G11.12)
• sfr1 (SPBC28F2.07)
• sws1 (SPBC11B10.06)

Genotypes:

• cig1delta crs1delta
• dmc1delta fml1delta
• dmc1delta fml1delta rlp1delta
• dmc1delta fml1delta rlp1delta rqh1delta
• dmc1delta fml1delta rqh1delta
• dmc1delta mus81delta
• dmc1delta rad55delta
• dmc1delta rdl1delta
• dmc1delta rlp1delta
• dmc1delta rlp1delta rqh1delta
• dmc1delta rqh1delta
• dmc1delta sfr1delta
• fml1delta rad55delta
• fml1delta rad55delta rqh1delta
• fml1delta rdl1delta
• fml1delta rlp1delta
• fml1delta rlp1delta rqh1delta
• fml1delta rqh1delta
• fml1delta rqh1delta sfr1delta
• fml1delta sfr1delta
• hhp1+(wild type)[Knockdown] hhp2delta
• hhp1delta hhp2delta
• mus81delta rad55delta
• mus81delta rdl1delta
• mus81delta rlp1delta
• mus81delta sfr1delta
• rad55delta rlp1delta
• rad55delta rqh1delta
• rad55delta sfr1delta
• rdl1delta rlp1delta
• rdl1delta rlp1delta sws1delta
• rec10-155::LEU2(deletes aa 691-791 and adds IVVIMGGMLE at C-terminus)/rec10-155::LEU2(deletes aa 691-791 and adds IVVIMGGMLE at C-terminus) rec25delta/rec25delta
• rec25delta/rec25delta rec27delta/rec27delta
• rec25delta/rec25delta rec8delta/rec8delta
• rlp1delta rqh1delta
• rlp1delta sfr1delta
• rqh1delta sfr1delta

FYPO:0003179 - decreased intragenic meiotic recombination

References:

• PMID:15654094
• PMID:18514516
• PMID:19470480
• PMID:19911044
• PMID:25414342
• PMID:25993311
• PMID:30640914

Genes:

• cdc13 (SPBC582.03)
• cdc2 (SPBC11B10.09)
• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)
• crs1 (SPBC2G2.09c)
• ctp1 (SPCC338.08)
• dmc1 (SPAC8E11.03c)
• exo1 (SPBC29A10.05)
• fml1 (SPAC9.05)
• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• hop1 (SPBC1718.02)
• mek1 (SPAC14C4.03)
• mus81 (SPCC4G3.05c)
• puc1 (SPBC19F5.01c)
• rad50 (SPAC1556.01c)
• rad55 (SPAC3C7.03c)
• rdl1 (SPAC17H9.03c)
• rec10 (SPAC25G10.04c)
• rec12 (SPAC17A5.11)
• rec25 (SPAC17A5.18c)
• rec27 (SPBC577.05c)
• rlp1 (SPBC1685.11)
• rqh1 (SPAC2G11.12)
• sfr1 (SPBC28F2.07)
• sws1 (SPBC11B10.06)

Genotypes:

• cdc13+(wild type)[Overexpression] crs1delta
• cdc2+(wild type)[Overexpression] crs1delta
• cig1delta cig2delta
• cig1delta crs1delta
• crs1delta puc1+(wild type)[Overexpression]
• ctp1delta/ctp1delta exo1delta/exo1delta
• ctp1delta/ctp1delta exo1delta/exo1delta rad50delta/rad50delta
• dmc1delta fml1delta
• dmc1delta fml1delta rlp1delta
• dmc1delta fml1delta rlp1delta rqh1delta
• dmc1delta fml1delta rqh1delta
• dmc1delta mus81delta
• dmc1delta rad55delta
• dmc1delta rdl1delta
• dmc1delta rlp1delta
• dmc1delta rlp1delta rqh1delta
• dmc1delta rqh1delta
• dmc1delta sfr1delta
• exo1delta/exo1delta rad50delta/rad50delta
• fml1delta rad55delta
• fml1delta rad55delta rqh1delta
• fml1delta rdl1delta
• fml1delta rlp1delta
• fml1delta rlp1delta rqh1delta
• fml1delta rqh1delta
• fml1delta rqh1delta sfr1delta
• fml1delta sfr1delta
• hhp1-as(M84G aa) hhp2delta
• hhp1delta hhp2delta
• hop1delta/hop1delta mek1delta/mek1delta rad50S(K81I aa)/rad50S(K81I aa)
• hop1delta/hop1delta rad50S(K81I aa)/rad50S(K81I aa)
• mek1delta/mek1delta rad50S(K81I aa)/rad50S(K81I aa)
• mus81delta rad55delta
• mus81delta rdl1delta
• mus81delta rlp1delta
• mus81delta sfr1delta
• mus81delta/mus81delta rec12-152(unknown)/rec12-152(unknown)
• rad55delta rlp1delta
• rad55delta rqh1delta
• rad55delta sfr1delta
• rdl1delta rlp1delta
• rdl1delta rlp1delta sws1delta
• rec10-155::LEU2(deletes aa 691-791 and adds IVVIMGGMLE at C-terminus)/rec10-155::LEU2(deletes aa 691-791 and adds IVVIMGGMLE at C-terminus) rec25delta/rec25delta
• rec25delta/rec25delta rec27delta/rec27delta
• rlp1delta rqh1delta
• rlp1delta sfr1delta
• rqh1delta sfr1delta

FYPO:0000470 - decreased mating type switching

References:

• PMID:15537537
• PMID:18388861
• PMID:22042869
• PMID:30759238

Genes:

• cdc23 (SPBC1347.10)
• mus81 (SPCC4G3.05c)
• swi1 (SPBC216.06c)
• swi10 (SPBC4F6.15c)
• swi2 (SPAC1142.03c)
• swi3 (SPBC30D10.04)
• swi5 (SPBC409.03)
• swi6 (SPAC664.01c)

Genotypes:

• cdc23-M36(D232G,V265I aa) swi1-1(disruption)
• cdc23-M36(D232G,V265I aa) swi1-111(unknown)
• cdc23-M36(D232G,V265I aa) swi3-1(unknown)
• cdc23-M36(D232G,V265I aa) swi3-146(unknown)
• cdc23-M36(D232G,V265I aa) swi3-157(unknown)
• mus81delta swi10delta
• swi2delta swi5delta
• swi2delta swi6-(unknown)

FYPO:0005058 - decreased meiotic DNA double-strand break clipping

References:

• PMID:19139281
• PMID:19911044

Genes:

• ctp1 (SPCC338.08)
• hop1 (SPBC1718.02)
• mek1 (SPAC14C4.03)
• mre11 (SPAC13C5.07)
• rad50 (SPAC1556.01c)

Genotypes:

• ctp1delta/ctp1delta rad50S(K81I aa)/rad50S(K81I aa)
• ctp1delta/ctp1delta rad50delta/rad50delta
• hop1delta/hop1delta mek1delta/mek1delta
• hop1delta/hop1delta rad50S(K81I aa)/rad50S(K81I aa)
• mek1delta/mek1delta rad50S(K81I aa)/rad50S(K81I aa)
• mre11-D65N(aa)/mre11-D65N(aa) rad50S(K81I aa)/rad50S(K81I aa)
• mre11-D65N(aa)/mre11-D65N(aa) rad50delta/rad50delta

FYPO:0003615 - decreased meiotic DNA double-strand break formation

References:

• PMID:25993311
• PMID:30640914

Genes:

• cdc2 (SPBC11B10.09)
• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)
• crs1 (SPBC2G2.09c)
• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• rad3 (SPBC216.05)

Genotypes:

• cdc2-asM17(K79E,F84G aa) rad3delta
• cig1delta/cig1delta cig2delta/cig2delta
• cig1delta/cig1delta crs1delta/crs1delta
• hhp1-as(M84G aa) hhp2delta

FYPO:0000485 - decreased meiotic recombination

References:

• PMID:12750522
• PMID:17632059

Genes:

• lig4 (SPCC1183.05c)
• psc3 (SPAC17H9.20)
• rap1 (SPBC1778.02)
• rec11 (SPCC4E9.01c)
• taz1 (SPAC16A10.07c)

Genotypes:

• lig4delta rap1delta
• lig4delta taz1delta
• psc3+(wild type)[Overexpression]/psc3+(wild type)[Overexpression] rec11delta/rec11delta

FYPO:0005433 - decreased meiotic recombination at hotspot

References:

• PMID:15654094

Genes:

• mre11 (SPAC13C5.07)
• rad16 (SPCC970.01)
• rad50 (SPAC1556.01c)
• rec12 (SPAC17A5.11)

Genotypes:

• mre11-D65N(aa)/mre11-D65N(aa) rec12delta/rec12delta
• rad16delta/rad16delta rec12-152(unknown)/rec12-152(unknown)
• rad50S(K81I aa)/rad50S(K81I aa) rec12-152(unknown)/rec12-152(unknown)

FYPO:0005141 - decreased meiotic recombination double-strand break repair

References:

• PMID:15238514

Genes:

• rad52 (SPAC30D11.10)
• rti1 (SPBC119.14)

Genotypes:

• rad52delta rti1delta

FYPO:0004089 - decreased meiotic recombination during zygotic meiosis

References:

• PMID:25891897

Genes:

• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)
• puc1 (SPBC19F5.01c)

Genotypes:

• cig1delta cig2delta puc1delta

FYPO:0004734 - decreased misfolded protein degradation

References:

• PMID:26152728

Genes:

• hsp104 (SPBC16D10.08c)
• nas6 (SPAC6C3.08)
• rkr1 (SPBC21D10.09c)
• rqc1 (SPAC1142.01)
• sdj1 (SPAC22E12.03c)
• ssa2 (SPCC1739.13)

Genotypes:

• hsp104delta sdj1-L169P(aa)
• nas6delta sdj1-L169P(aa)
• rkr1delta sdj1-L169P(aa)
• rqc1delta sdj1-L169P(aa)
• sdj1-L169P(aa) ssa2delta

FYPO:0003286 - decreased mitotic chromosome condensation

References:

• PMID:21633354
• PMID:26869222

Genes:

• cdc25 (SPAC24H6.05)
• cut3 (SPBC146.03c)
• sfc3 (SPBC336.07)

Genotypes:

• cdc25-22(C532Y aa)[Knockdown] cut3-477(S1147P aa)[Knockdown]
• cut3-477(S1147P aa) sfc3-1(unknown)

FYPO:0005424 - decreased mitotic chromosome condensation during telophase

References:

• PMID:21540296

Genes:

• cut14 (SPBP4H10.06c)
• nda3 (SPBC26H8.07c)

Genotypes:

• cut14-208(S861P aa) nda3-KM311(G93E aa)

FYPO:0008332 - decreased mRNA poly(A) tail uridylation

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)
• lsm1 (SPBC3D6.08c)

Genotypes:

• cid1delta lsm1delta

FYPO:0003029 - decreased mRNA splicing, via spliceosome

References:

• PMID:10545451
• PMID:26730850
• PMID:28446597
• PMID:30810475
• PMID:31927482

Genes:

• acp1 (SPAC12B10.07)
• brr2 (SPAC9.03c)
• pht1 (SPBC11B10.10c)
• ppk8 (SPAC22G7.08)
• prp16 (SPBC1711.17)
• prp22 (SPAC10F6.02c)
• prp4 (SPCC777.14)
• res1 (SPBC725.16)
• smn1 (SPAC2G11.08c)
• spp42 (SPAC4F8.12c)
• usp107 (SPBC839.10)

Genotypes:

• acp1delta tdSMN(Ub-DHFRts-smn1)
• pht1delta prp16-DAmP(CDS.prp16:natMX6:3UTR.prp16)[Overexpression]
• pht1delta usp107-DAmP(CDS.usp107:natMX6:3UTR.usp107)[Overexpression]
• ppk8'-2(A476T,T477A nt) ppk8+(wild type) prp4-as2(F238A aa)
• ppk8'-4(T64A,C65T,A69T nt) ppk8+(wild type) prp4-as2(F238A aa)
• ppk8'-5(T64A,G66C nt) ppk8+(wild type) prp4-as2(F238A aa)
• ppk8'-6(T64C,G66C nt) ppk8+(wild type) prp4-as2(F238A aa)
• prp16-F528S(aa) prp22-S663A(aa)
• prp4-73(C235Y aa) spp41-1(unknown)
• prp4-73(C235Y aa) spp42-1(unknown)
• prp4-as2(F238A aa) res1'-12(A224T,A225T,G226C,T229A,T230A nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-13(A225T,G226C,T229A,T230A nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-2B(T229A,T230A,A340T nt) res1+(wild type)
• prp4-as2(F238A aa) res1'-6(T229A,T230A,G231A nt) res1+(wild type)

FYPO:0003244 - decreased mRNA splicing, via spliceosome, intron-specific

References:

• PMID:28947618
• PMID:38833506

Genes:

• cdk9 (SPBC32H8.10)
• saf1 (SPCC663.11)
• ubp15 (SPBC713.02c)
• ubp5 (SPCC188.08c)

Genotypes:

• cdk9+(wild type)[Knockdown] saf1delta
• ubp15delta ubp5delta

FYPO:0003175 - decreased nucleotide-excision repair during cellular response to UV

References:

• PMID:10652237

Genes:

• rhp23 (SPBC2D10.12)
• uve1 (SPBC19C7.09c)

Genotypes:

• rhp23delta uve1delta

FYPO:0004545 - decreased proteasomal ubiquitin-dependent protein degradation

References:

• PMID:21215368

Genes:

• ddb1 (SPAC17H9.10c)
• spd1 (SPAC29B12.03)

Genotypes:

• ddb1delta spd1delta

FYPO:0005182 - decreased protein degradation during cellular response to UV

References:

• PMID:21493688

Genes:

• cdt1 (SPBC428.18)
• pcn1 (SPBC16D10.09)
• rad13 (SPBC3E7.08c)
• uve1 (SPBC19C7.09c)

Genotypes:

• cdt1-PIP28A8-PIP301A10(Q6A,L9A,FSVRK11AAAAA,R17A,Q279A,LRQSS282AAAAA,R290A,RKK292AAA aa) pcn1-K164R(aa)
• rad13delta uve1delta

FYPO:0007404 - decreased protein degradation during mitotic anaphase

References:

• PMID:24583014

Genes:

• cdc13 (SPBC582.03)
• cut1 (SPCC5E4.04)
• cut2 (SPBC14C8.01c)

Genotypes:

• cdc13delta1-67(aa) cut1+(wild type)[Overexpression] cut2+(wild type)[Overexpression]

FYPO:0006519 - decreased protein degradation during mitotic G1 phase

References:

• PMID:9303310

Genes:

• cdc10 (SPBC336.12c)
• cdc13 (SPBC582.03)
• rum1 (SPBC32F12.09)

Genotypes:

• cdc10-129(T429A aa) cdc13+(wild type)[Knockdown] rum1delta

FYPO:0002798 - decreased protein degradation during nitrogen starvation

References:

• PMID:32361273

Genes:

• cdc10 (SPBC336.12c)
• cdc2 (SPBC11B10.09)
• mad2 (SPBC20F10.06)
• par1 (SPCC188.02)

Genotypes:

• cdc10-V50(H362Y aa) par1delta
• cdc2-3w(C67Y aa) par1delta
• mad2delta par1delta

FYPO:0000846 - decreased protein degradation during vegetative growth

References:

• PMID:19592249
• PMID:21215368
• PMID:26152728
• PMID:28366744

Genes:

• apc14 (SPAC27D7.05c)
• ark1 (SPCC320.13c)
• cdt2 (SPAC17H9.19c)
• dis2 (SPBC776.02c)
• nda3 (SPBC26H8.07c)
• sdj1 (SPAC22E12.03c)
• spd1 (SPAC29B12.03)
• ssa1 (SPAC13G7.02c)

Genotypes:

• apc14delta ark1-as3(L166A,S229A,Q28R,Q176R aa) nda3-311(unknown)
• ark1-as3(L166A,S229A,Q28R,Q176R aa) dis2delta nda3-KM311(G93E aa)
• cdt2delta spd1delta
• sdj1-L169P(aa) ssa1delta

FYPO:0005679 - decreased protein deubiquitination following cellular response to hydroxyurea during vegetative growth

References:

• PMID:27151298

Genes:

• ubp12 (SPCC1494.05c)
• ubp15 (SPBC713.02c)
• ubp16 (SPCC1682.12c)
• ubp2 (SPAC328.06)

Genotypes:

• ubp12-NES ubp15-NES ubp16delta
• ubp12-NES ubp15-NES ubp16delta ubp2delta

FYPO:0001911 - decreased protein glycosylation during vegetative growth

References:

• PMID:34851357

Genes:

• alg12 (SPBC1734.12c)
• alg3 (SPAC7D4.06c)
• alg6 (SPBC342.01c)
• alg9 (SPAC1834.05)

Genotypes:

• alg12delta alg6delta
• alg3delta alg6delta
• alg6delta alg9delta

FYPO:0004836 - decreased protein oxidation during cellular response to hydrogen peroxide

References:

• PMID:24268782
• PMID:33225241

Genes:

• atf1 (SPBC29B5.01)
• ctt1 (SPCC757.07c)
• mas5 (SPBC1734.11)
• sty1 (SPAC24B11.06c)
• trx1 (SPAC7D4.07c)
• txl1 (SPBC577.08c)

Genotypes:

• atf1delta mas5delta
• ctt1delta mas5delta
• mas5delta sty1delta
• trx1delta txl1delta

FYPO:0002679 - decreased protein phosphorylation

References:

• PMID:19625445
• PMID:20679485
• PMID:24663817
• PMID:31644361
• PMID:34402513

Genes:

• cdc2 (SPBC11B10.09)
• cdr1 (SPAC644.06c)
• cdr2 (SPAC57A10.02)
• cds1 (SPCC18B5.11c)
• cpc2 (SPAC6B12.15)
• crb2 (SPBC342.05)
• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• hta1 (SPCC622.08c)
• hta2 (SPAC19G12.06c)
• pck2 (SPBC12D12.04c)
• rad4 (SPAC23C4.18c)
• rad9 (SPAC664.07c)

Genotypes:

• cdc2-as(F84G aa) hhp1-as(M84G aa) hhp2delta
• cdr1+(wild type)[Overexpression] cdr1delta cdr2delta
• cds1delta rad4-C13Y(aa)
• cpc2delta pck2delta
• crb2-F400A(aa) crb2-S548A(aa)
• crb2-K619M(aa) crb2-S548A(aa)
• crb2-K619M(aa) crb2-S548A(aa) hta1-S129A(aa) hta2-S128A(aa)
• crb2-K619M(aa) hta1-S129A(aa) hta2-S128A(aa)
• crb2-S548A(aa) crb2-T215A,T235A(aa)
• crb2-S548A(aa) hta1-S129A(aa) hta2-S128A(aa)
• hta1-S129A(aa) hta2-S128A(aa)
• rad4-E368K(aa) rad9-T412A,S423A(aa)

FYPO:0005479 - decreased protein phosphorylation during cellular response to arsenite ion

References:

• PMID:16087744

Genes:

• win1 (SPAC1006.09)
• wis4 (SPAC9G1.02)

Genotypes:

• win1-1(unknown) wis4delta

FYPO:0002897 - decreased protein phosphorylation during cellular response to DNA damage

References:

• PMID:23211746

Genes:

• ast1 (SPCC962.05)
• exo1 (SPBC29A10.05)
• rad2 (SPAC3G6.06c)

Genotypes:

• ast1delta exo1+(wild type)[Knockdown] rad2delta

FYPO:0004173 - decreased protein phosphorylation during cellular response to heat

References:

• PMID:10398679
• PMID:9321395

Genes:

• ptc1 (SPCC4F11.02)
• ptc3 (SPAC2G11.07c)
• pyp1 (SPAC26F1.10c)
• wis1 (SPBC409.07c)

Genotypes:

• ptc1delta ptc3delta
• pyp1delta wis1-AA(S469A,T473A aa)[Overexpression]

FYPO:0002446 - decreased protein phosphorylation during cellular response to hydrogen peroxide

References:

• PMID:20919928
• PMID:22918952
• PMID:9321395

Genes:

• cdc2 (SPBC11B10.09)
• mak2 (SPAC27E2.09)
• mak3 (SPCC74.06)
• pmk1 (SPBC119.08)
• pyp1 (SPAC26F1.10c)
• rad3 (SPBC216.05)
• wis1 (SPBC409.07c)

Genotypes:

• cdc2-as(F84G aa) pmk1delta rad3delta
• mak2delta mak3delta
• pyp1delta wis1-AA(S469A,T473A aa)[Overexpression]

FYPO:0002098 - decreased protein phosphorylation during cellular response to hydroxyurea

References:

• PMID:12093738
• PMID:18180284
• PMID:21099360
• PMID:22918952

Genes:

• cdc2 (SPBC11B10.09)
• cds1 (SPCC18B5.11c)
• hsk1 (SPBC776.12c)
• mik1 (SPBC660.14)
• pmk1 (SPBC119.08)
• rad3 (SPBC216.05)
• wee1 (SPCC18B5.03)

Genotypes:

• cdc2-as(F84G aa) pmk1delta rad3delta
• cds1delta hsk1-1312(S314I aa)
• hsk1-89(L339P,E403K,L416P aa) hsk1-KK(KK129RS aa)
• hsk1-89(L339P,E403K,L416P aa) hsk1-KK(KK129RS aa)[Overexpression]
• hsk1-89(L339P,E403K,L416P aa) hsk1-kd(K129D aa)
• hsk1-89(L339P,E403K,L416P aa) hsk1-kd(K129D aa)[Overexpression]
• mik1delta wee1-50(G850E aa)

FYPO:0002470 - decreased protein phosphorylation during cellular response to ionizing radiation

References:

• PMID:15226425

Genes:

• hta1 (SPCC622.08c)
• hta2 (SPAC19G12.06c)

Genotypes:

• hta1-S129A(aa) hta2-S128A(aa)

FYPO:0002993 - decreased protein phosphorylation during cellular response to methyl methanesulfonate

References:

• PMID:32341083

Genes:

• cds1 (SPCC18B5.11c)
• mcm4 (SPCC16A11.17)
• mus81 (SPCC4G3.05c)

Genotypes:

• cdc21-M68(unknown) mus81delta
• cds1delta mcm4-tstd(Ub-DHFRts-mcm4)

FYPO:0002376 - decreased protein phosphorylation during cellular response to osmotic stress

References:

• PMID:28924043
• PMID:31477575
• PMID:9321395

Genes:

• atf1 (SPBC29B5.01)
• cdr1 (SPAC644.06c)
• pyp1 (SPAC26F1.10c)
• sty1 (SPAC24B11.06c)
• wis1 (SPBC409.07c)

Genotypes:

• atf1delta sty1delta
• cdr1+(wild type) cdr1-K41A(aa)
• pyp1delta wis1-AA(S469A,T473A aa)[Overexpression]

FYPO:0007620 - decreased protein phosphorylation during cellular response to oxidative stress

References:

• PMID:37572670

Genes:

• pyp1 (SPAC26F1.10c)
• pyp2 (SPAC19D5.01)
• sty1 (SPAC24B11.06c)
• wis1 (SPBC409.07c)

Genotypes:

• pyp1delta pyp2delta sty1-T97A(aa) wis1-DD(S469D,T473D aa)

FYPO:0005749 - decreased protein phosphorylation during glucose starvation

References:

• PMID:22140232

Genes:

• ppk9 (SPAC23H4.02)
• ssp2 (SPCC74.03c)

Genotypes:

• ppk9delta ssp2delta

FYPO:0005577 - decreased protein phosphorylation during meiotic cell cycle

References:

• PMID:21084840
• PMID:25993311

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)

Genotypes:

• hhp1-as(M84G aa) hhp2delta
• rad3delta tel1delta

FYPO:0004357 - decreased protein phosphorylation during mitosis

References:

• PMID:12546793

Genes:

• cdc16 (SPAC6F6.08c)
• cdc7 (SPBC21.06c)

Genotypes:

• cdc16::ura4+ cdc7-A20(unknown)

FYPO:0004261 - decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation

References:

• PMID:21098122

Genes:

• ctp1 (SPCC338.08)
• rad3 (SPBC216.05)

Genotypes:

• ctp1delta rad3delta

FYPO:0005034 - decreased protein phosphorylation during nitrogen starvation

References:

• PMID:38971312

Genes:

• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)
• tor1 (SPBC30D10.10c)

Genotypes:

• rad3delta tor1delta
• tel1delta tor1delta

FYPO:0001885 - decreased protein phosphorylation during salt stress

References:

• PMID:26108447
• PMID:39540318

Genes:

• cfr1 (SPAC6G9.12)
• ent3 (SPCC794.11c)
• gga21 (SPAC1F3.05)
• gga22 (SPBC25H2.16c)
• nem1 (SPBC3B8.10c)
• stt4 (SPBC577.06c)
• win1 (SPAC1006.09)
• wis4 (SPAC9G1.02)

Genotypes:

• cfr1delta ent3delta
• cfr1delta nem1delta
• cfr1delta stt4+(wild type)[Ectopic]
• gga21delta gga22delta
• win1delta wis4delta

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

• PMID:12764130
• PMID:15829570
• PMID:18793338
• PMID:19037094
• PMID:20164182
• PMID:21035342
• PMID:22976295
• PMID:23671279
• PMID:24247430
• PMID:24344203
• PMID:31833215
• PMID:3357510
• PMID:34402513
• PMID:37787465
• PMID:38971312
• PMID:39010328
• PMID:39910760
• PMID:9135148
• PMID:9321395
• PMID:9693384
• PMID:9755169
• PMID:9790601

Genes:

• cdc18 (SPBC14C8.07c)
• cdc2 (SPBC11B10.09)
• cdc25 (SPAC24H6.05)
• cdc6 (SPBC336.04)
• chk1 (SPCC1259.13)
• cpc2 (SPAC6B12.15)
• csk1 (SPAC1D4.06c)
• ecl1 (SPCC70.12c)
• ecl2 (SPBP35G2.16c)
• ecl3 (SPBC8E4.12c)
• gcn2 (SPBC36B7.09)
• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• hri2 (SPAC222.07c)
• isp7 (SPAC25B8.13c)
• mcs6 (SPBC19F8.07)
• mei3 (SPBC119.04)
• mkh1 (SPAC1F3.02c)
• pat1 (SPBC19C2.05)
• pck2 (SPBC12D12.04c)
• pib2 (SPBC9B6.03)
• pph3 (SPBC26H8.05c)
• rad3 (SPBC216.05)
• rga2 (SPAC26A3.09c)
• rga4 (SPBC28E12.03)
• rga6 (SPBC354.13)
• rga7 (SPBC23G7.08c)
• rgp1 (SPBC23E6.08)
• rho1 (SPAC1F7.04)
• rho2 (SPAC16.01)
• ric1 (SPAC1851.04c)
• ryh1 (SPAC4C5.02c)
• shk1 (SPBC1604.14c)
• sin1 (SPAPYUG7.02c)
• ste20 (SPBC12C2.02c)
• tea1 (SPCC1223.06)
• tel1 (SPCC23B6.03c)
• tor1 (SPBC30D10.10c)
• tor2 (SPBC216.07c)
• win1 (SPAC1006.09)
• wis1 (SPBC409.07c)
• wis4 (SPAC9G1.02)

Genotypes:

• cdc18-T6A(T10A,T46A,T60A,T104A,T134A,T374A aa) cdc2-33(A177T aa)
• cdc2-3w(C67Y aa) cdc25delta
• cdc2-M63(G227C aa) cdc2-T167E(aa)[Overexpression]
• cdc6-ts3(R1064Q aa) chk1-1(E92D aa)
• cpc2delta gcn2delta
• cpc2delta hri2delta
• csk1delta mcs6-ts1(unknown)
• ecl1delta ecl2delta ecl3delta
• hhp1-as(M84G aa) hhp2delta
• isp7+(wild type)[Overexpression] tor2-S1837E(aa)
• mei3+(wild type)[Overexpression] pat1+(wild type)[Overexpression]
• mkh1delta rho1-G15V(aa)[Overexpression]
• pck2delta rga4delta
• pck2delta rho1-G15V(aa)[Overexpression]
• pib2delta tor2-13(C2163R,I2280V,Q2305L aa)
• pib2delta tor2-L2048S(aa)
• pib2delta tor2-ts6(S550P,K710M aa)
• pph3delta tor2-L2048S(aa)
• rad3delta tel1delta
• rga2delta rho2delta
• rga6delta rho2delta
• rga7delta rho2delta
• rgp1delta tor1-T1972A(aa)
• ric1delta tor1-T1972A(aa)
• ryh1-Q70L(aa) sin1delta
• ryh1-Q70L(aa) ste20delta
• ryh1delta tor1-T1972A(aa)
• shk1-K415R(aa)[Overexpression] tea1+(wild type)[Overexpression]
• tel1delta tor1delta
• tor2+(wild type) tor2-KD(D2140A aa)
• win1+(wild type)[Overexpression] wis1-4(S469E,T473E aa)
• win1-1(unknown) wis4delta

FYPO:0001422 - decreased protein processing during vegetative growth

References:

• PMID:21153812
• PMID:26221037
• PMID:27655872
• PMID:28202541
• PMID:28821619
• PMID:31239353

Genes:

• cdb4 (SPAC23H4.09)
• cdc48 (SPAC1565.08)
• dsc1 (SPBC947.10)
• isp6 (SPAC4A8.04)
• mga2 (SPAC26H5.05)
• nup132 (SPAC1805.04)
• pmt3 (SPBC365.06)
• psp3 (SPAC1006.01)
• rbd2 (SPCC790.03)
• slx8 (SPBC3D6.11c)
• sre1 (SPBC19C2.09)
• sre2 (SPBC354.05c)
• sxa2 (SPAC1296.03c)
• ufd1 (SPBC16A3.09c)
• xpa1 (SPBC18A7.01)

Genotypes:

• cdb4delta isp6delta psp3delta sxa2delta xpa1delta
• cdc48-A360D(aa) rbd2delta
• cdc48-A580V(aa) rbd2delta
• cdc48-E319K(aa) rbd2delta
• cdc48-N552I(aa) rbd2delta
• cdc48-R758C(aa) rbd2delta
• dsc1delta sre2delta1-422(aa)
• isp6delta psp3delta
• mga2delta sre1-MP(CACCCCAT(-528)ATACCATA,CAGTCCAC(-485)ATATCATA)[Knockdown]
• nup132delta pmt3+(wild type)[Overexpression]
• nup132delta pmt3+(wild type)[Overexpression] slx8-29(unknown)
• rbd2delta sre2delta1-422(aa)
• rbd2delta ufd1-7(L68P,G226D aa)
• rbd2delta ufd1-8(L78P aa)

FYPO:0002768 - decreased protein ubiquitination during vegetative growth

References:

• PMID:27655872
• PMID:33574613

Genes:

• cul4 (SPAC3A11.08)
• ddb1 (SPAC17H9.10c)
• dsc1 (SPBC947.10)
• iss10 (SPAC7D4.14c)
• sre2 (SPBC354.05c)
• tor2 (SPBC216.07c)
• ubi4 (SPBC337.08c)

Genotypes:

• cul4delta tor2-ts6(S550P,K710M aa)
• ddb1delta tor2-ts6(S550P,K710M aa)
• dsc1delta sre2-MS+E755L(1-422,E755L aa)
• dsc1delta sre2-MS+G772L,N773L,Y774L(1-422,G772L,N773L,Y774L aa)
• dsc1delta sre2-MS+P767L(1-422,P767L aa)
• dsc1delta sre2-MS+R753L(1-422,R753L aa)
• dsc1delta sre2-MS+S760L(1-422,S760L aa)
• dsc1delta sre2-MS+S765L(1-422,S765L aa)
• dsc1delta sre2-MS+W771L(1-422,W771L aa)
• pir1-SD(S285D aa) tor2-ts6(S550P,K710M aa)
• tor2-ts6(S550P,K710M aa) ubi4delta

FYPO:0005443 - decreased proteolysis during vegetative growth

References:

• PMID:15329725

Genes:

• cut2 (SPBC14C8.01c)
• rad21 (SPCC338.17c)

Genotypes:

• cut2-EA2(D122A,E124A aa) rad21-D232S(aa)

FYPO:0003923 - decreased rate of mitotic DNA replication elongation

References:

• PMID:34108240

Genes:

• cdc45 (SPAC17D4.02)
• cds1 (SPCC18B5.11c)

Genotypes:

• cdc45-3A(S275A,S322A,S397A aa) cds1delta
• cdc45-3D(S275D,S322D,S397D aa) cds1delta

FYPO:0005631 - decreased rate of protein degradation during vegetative growth

References:

• PMID:10209119
• PMID:9653157

Genes:

• pop1 (SPBC1718.01)
• pop2 (SPAC4D7.03)
• rum1 (SPBC32F12.09)

Genotypes:

• pop1delta pop2delta
• pop2delta rum1delta

FYPO:0007532 - decreased replication fork colocalization with nuclear pore complex

References:

• PMID:33159083

Genes:

• exo1 (SPBC29A10.05)
• nup131 (SPBP35G2.06c)
• nup132 (SPAC1805.04)
• pli1 (SPAC1687.05)
• rad50 (SPAC1556.01c)
• rfp1 (SPAC19A8.10)
• rfp2 (SPAC343.18)

Genotypes:

• exo1delta rad50delta
• nup131delta nup132delta
• nup132delta pli1delta
• rfp1delta rfp2delta

FYPO:0007255 - decreased replication fork processing

References:

• PMID:34108240

Genes:

• cdc45 (SPAC17D4.02)
• cds1 (SPCC18B5.11c)

Genotypes:

• cdc45-3A(S275A,S322A,S397A aa) cds1delta
• cdc45-3D(S275D,S322D,S397D aa) cds1delta

FYPO:0003589 - decreased replication slippage during replication fork processing

References:

• PMID:29215009
• PMID:33159083
• PMID:38917328

Genes:

• alm1 (SPAC1486.04c)
• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• nup131 (SPBP35G2.06c)
• nup132 (SPAC1805.04)
• nup60 (SPCC285.13c)
• pku70 (SPCC126.02c)
• pmt3 (SPBC365.06)
• rad50 (SPAC1556.01c)
• rpn10 (SPAC637.10c)

Genotypes:

• alm1delta nup60delta
• alm1delta pmt3-KallR(K14R,K30R,K39R,K51R,K53R,K54R,K60R,K63R,K71R aa)
• ctp1delta exo1delta
• ctp1delta exo1delta pku70delta
• ctp1delta rad50delta
• exo1delta pku70delta
• nup131delta nup132delta
• nup132delta rpn10delta
• nup60delta rpn10delta
• pmt3-KallR(K14R,K30R,K39R,K51R,K53R,K54R,K60R,K63R,K71R aa) rpn10delta

FYPO:0004009 - decreased rRNA transcription

References:

• PMID:2839305
• PMID:40132111

Genes:

• cbp1 (SPBC1105.04c)
• clr4 (SPBC428.08c)
• top1 (SPBC1703.14c)
• top2 (SPBC1A4.03c)

Genotypes:

• cbp1delta clr4delta
• top1-701(unknown) top2-191(unknown)

FYPO:0005357 - decreased site-specific DNA replication termination at RTS1 barrier

References:

• PMID:19416828

Genes:

• eso1 (SPBC16A3.11)
• kpa1 (SPCC553.07c)
• pmt3 (SPBC365.06)
• rev3 (SPAC688.10)
• rqh1 (SPAC2G11.12)
• rtf2 (SPAC1D4.09c)
• srs2 (SPAC4H3.05)

Genotypes:

• eso1delta kpa1delta rev3delta rtf2delta
• eso1delta rtf2delta
• kpa1delta rtf2delta
• pmt3delta rtf2delta
• rev3delta rtf2delta
• rqh1delta rtf2delta
• rtf2delta srs2delta

FYPO:0006073 - decreased small RNA degradation

References:

• PMID:28541282

Genes:

• cid12 (SPCC663.12)
• cid14 (SPAC12G12.13c)

Genotypes:

• cid12delta cid14delta

FYPO:0005786 - decreased spatial extent of double-strand break processing

References:

• PMID:21931565
• PMID:27729451

Genes:

• cdc24 (SPAC8F11.07c)
• exo1 (SPBC29A10.05)
• rqh1 (SPAC2G11.12)

Genotypes:

• cdc24-ts(C114R aa) exo1delta
• cdc24-ts(C114R aa) rqh1delta
• exo1delta rqh1delta

FYPO:0005609 - decreased spatial extent of histone H2B-K119 ubiquitination at double-strand break site during vegetative growth

References:

• PMID:27098497

Genes:

• spd1 (SPAC29B12.03)
• wdr70 (SPAC343.17c)

Genotypes:

• spd1delta wdr70delta

FYPO:0008118 - decreased splicing of introns with branch point-distant 3’-splice site

References:

• PMID:36095128

Genes:

• ubp15 (SPBC713.02c)
• ubp5 (SPCC188.08c)

Genotypes:

• ubp15delta ubp5delta

FYPO:0002876 - decreased transcription

References:

• PMID:11781565

Genes:

• cig2 (SPAPB2B4.03)
• res1 (SPBC725.16)

Genotypes:

• Pcig2delta-147--40-LacZ((-170)-(-148),(-39)-LacZ fusion) res1+(wild type)[Overexpression]

FYPO:0003120 - decreased transcription during glucose starvation

References:

• PMID:11014802

Genes:

• git3 (SPCC1753.02c)
• git5 (SPBC32H8.07)
• gpa2 (SPAC23H3.13c)

Genotypes:

• git3-14(unknown) gpa2-R176H(aa)
• git3delta gpa2-R176H(aa)
• git5delta gpa2-R176H(aa)

FYPO:0006544 - decreased transcription during mitosis

References:

• PMID:9755169

Genes:

• cdc10 (SPBC336.12c)
• cdc13 (SPBC582.03)
• res1 (SPBC725.16)

Genotypes:

• cdc10-129(T429A aa) cdc13delta90(1-90 Δaa)[Overexpression]
• cdc13delta90(1-90 Δaa)[Overexpression] res1delta

FYPO:0005118 - decreased transcription during nitrogen starvation

References:

• PMID:9233811

Genes:

• mat1-Mc (SPBC23G7.09)
• ste11 (SPBC32C12.02)

Genotypes:

• mat1-Mc+(wild type)[Overexpression] ste11-(unknown)

FYPO:0003251 - decreased transcription from SRE promoter

References:

• PMID:32053662

Genes:

• gsk3 (SPAC1687.15)
• gsk31 (SPBC8D2.01)
• ssp2 (SPCC74.03c)

Genotypes:

• gsk31delta gsk3delta
• gsk31delta gsk3delta ssp2delta
• gsk31delta ssp2delta

FYPO:0001798 - decreased translation

References:

• PMID:35171902

Genes:

• epe1 (SPCC622.16c)
• git3 (SPCC1753.02c)

Genotypes:

• epe1+(wild type)[Overexpression] git3delta

FYPO:0004010 - decreased translation of ribosomal proteins during vegetative growth

References:

• PMID:2839305

Genes:

• top1 (SPBC1703.14c)
• top2 (SPBC1A4.03c)

Genotypes:

• top1-701(unknown) top2-191(unknown)

FYPO:0003954 - decreased triglyceride biosynthetic process

References:

• PMID:12963726

Genes:

• dga1 (SPCC1235.15)
• plh1 (SPBC776.14)

Genotypes:

• dga1delta plh1delta

FYPO:0006251 - decreased tRNA aminoacylation

References:

• PMID:28977649

Genes:

• sla1 (SPAC57A10.10c)
• trm1 (SPBC25D12.05)

Genotypes:

• sla1delta trm1delta

FYPO:0004031 - decreased UV-damage excision repair

References:

• PMID:9092661

Genes:

• rad13 (SPBC3E7.08c)
• rad2 (SPAC3G6.06c)
• uve1 (SPBC19C7.09c)

Genotypes:

• rad13::ura4+(disruption) rad2::ura4+(disruption) uvde::LEU2+(disruption)
• rad13::ura4+(disruption) uvde::LEU2+(disruption)

FYPO:0000778 - delayed onset of double-strand break repair

References:

• PMID:8026462

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)

Genotypes:

• hhp1::ura4+(nt544)(disruption)[Null] hhp2::m-TN3-LEU2(disruption)[Null]

FYPO:0005137 - delayed onset of meiotic DNA double-strand break formation

References:

• PMID:15238514

Genes:

• dmc1 (SPAC8E11.03c)
• rad51 (SPAC644.14c)

Genotypes:

• dmc1delta rad51delta

FYPO:0005911 - delayed onset of meiotic recombination double-strand break repair

References:

• PMID:19023408

Genes:

• rad57 (SPAC20H4.07)
• swi6 (SPAC664.01c)

Genotypes:

• rad57delta swi6delta

FYPO:0004628 - delayed onset of premeiotic DNA replication

References:

• PMID:30640914

Genes:

• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)

Genotypes:

• cig1delta cig2delta

FYPO:0004801 - delayed onset of premeiotic DNA replication during azygotic meiosis

References:

• PMID:25891897
• PMID:34067465

Genes:

• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)
• crs1 (SPBC2G2.09c)
• puc1 (SPBC19F5.01c)

Genotypes:

• cig1delta cig2delta puc1delta
• cig2delta/cig2delta crs1delta/crs1delta

FYPO:0006531 - delayed onset of protein degradation during meiosis

References:

• PMID:20383139

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)

Genotypes:

• hhp1-as(M84G aa) hhp2delta

FYPO:0002830 - delayed onset of protein phosphorylation during vegetative growth

References:

• PMID:12093738

Genes:

• cig2 (SPAPB2B4.03)
• mik1 (SPBC660.14)
• wee1 (SPCC18B5.03)

Genotypes:

• cig2delta mik1delta wee1-50(G850E aa)

FYPO:0004003 - delayed onset of replication fork processing

References:

• PMID:33159083

Genes:

• nup131 (SPBP35G2.06c)
• nup132 (SPAC1805.04)
• pli1 (SPAC1687.05)

Genotypes:

• nup131delta nup132delta
• nup132delta pli1delta

FYPO:0006355 - delayed onset of transcription during glucose starvation

References:

• PMID:28674280

Genes:

• arp8 (SPAC664.02c)
• snf21 (SPAC1250.01)
• snf22 (SPCC1620.14c)
• swr1 (SPAC11E3.01c)

Genotypes:

• arp8delta snf22delta
• snf21-36(V404A,E461K,S566L,I571V aa) snf22delta
• snf22delta swr1delta

FYPO:0002019 - elongated telomeres during vegetative growth

References:

• PMID:11676925
• PMID:12196391
• PMID:12589755
• PMID:12676088
• PMID:17429064
• PMID:18160711
• PMID:18615848
• PMID:19546237
• PMID:19620282
• PMID:22354040
• PMID:24925530
• PMID:25131669
• PMID:25245948
• PMID:26063574
• PMID:26365187
• PMID:29216371
• PMID:29422501
• PMID:29422503
• PMID:29774234
• PMID:30796050
• PMID:31131414
• PMID:34255844
• PMID:41201383

Genes:

• cay1 (SPBC2F12.12c)
• ccq1 (SPCC188.07)
• cdc2 (SPBC11B10.09)
• cds1 (SPCC18B5.11c)
• chk1 (SPCC1259.13)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• clr6 (SPBC36.05c)
• crb2 (SPBC342.05)
• est1 (SPBC2D10.13)
• hip1 (SPBC31F10.13c)
• hus1 (SPAC20G4.04c)
• mit1 (SPBP35G2.10)
• mre11 (SPAC13C5.07)
• nse2 (SPAC16A10.06c)
• pku70 (SPCC126.02c)
• pli1 (SPAC1687.05)
• pmt3 (SPBC365.06)
• pof8 (SPAC17G6.17)
• pol1 (SPAC3H5.06c)
• pot1 (SPAC26H5.06)
• poz1 (SPAC19G12.13c)
• rad1 (SPAC1952.07)
• rad17 (SPAC14C4.13)
• rad26 (SPAC9E9.08)
• rad3 (SPBC216.05)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rad9 (SPAC664.07c)
• rap1 (SPBC1778.02)
• rif1 (SPAC6F6.17)
• rqh1 (SPAC2G11.12)
• set1 (SPCC306.04c)
• spp1 (SPAC6B12.10c)
• spp2 (SPBC17D11.06)
• ssb1 (SPBC660.13c)
• ssu72 (SPAC3G9.04)
• stn1 (SPBC409.12c)
• taz1 (SPAC16A10.07c)
• tel1 (SPCC23B6.03c)
• tls1 (SPAC1D4.01)
• tor1 (SPBC30D10.10c)
• tpz1 (SPAC6F6.16c)
• trt1 (SPBC29A3.14c)

Genotypes:

• cay1delta tls1delta
• ccq1(1-441)-13xMyc-est1 ccq1delta
• ccq1(1-441)(442-735 Δaa) ccq1-13xMyc-est1
• ccq1(1-441)(442-735 Δaa) ccq1-13xMyc-est1 pmt3delta
• ccq1(1-441)(442-735 Δaa) pmt3delta
• ccq1(1-441)(442-735 Δaa) tpz1-K242R(aa)
• ccq1(139-735)(1-138 Δaa) ccq1-13xMyc-est1
• ccq1(500-735)(1-499 Δaa) ccq1-13xMyc-est1
• ccq1-13xMyc-est1 ccq1delta
• ccq1-13xMyc-est1 ccq1delta clr3delta
• ccq1-13xMyc-est1 ccq1delta clr4delta
• ccq1-13xMyc-est1 ccq1delta rad51delta
• ccq1-13xMyc-est1 ccq1delta rap1delta
• ccq1-13xMyc-est1 ccq1delta rif1delta
• ccq1-13xMyc-est1 ccq1delta tpz1-K242R(aa)
• ccq1-13xMyc-est1 clr3delta
• ccq1-13xMyc-est1 clr4delta
• ccq1-13xMyc-est1 mit1delta
• ccq1-13xMyc-est1 pmt3delta
• ccq1-13xMyc-est1 rap1delta
• ccq1-13xMyc-est1 rif1delta
• ccq1-13xMyc-est1 tpz1-K242R(aa)
• ccq1-13xMyc-est1 trt1delta
• ccq1-T93A-13xMyc-est1 ccq1delta
• ccq1-T93A(aa) trt1-PK-tpz1(trt1-9xPK-tpz1)
• cdc2-M68(unknown) ssu72delta
• cds1+(wild type)[Overexpression] pol1+(wild type)[Overexpression] swi7-H4(unknown)
• cds1delta chk1delta taz1delta
• cds1delta set1::Kan(disruption)[Null]
• cds1delta taz1delta
• cds1delta tor1delta
• chk1delta set1::Kan(disruption)[Null]
• chk1delta ssu72delta
• chk1delta taz1delta
• chk1delta tor1delta
• clr6-1(G269D aa) hip1delta
• crb2delta taz1delta
• hus1delta set1::Kan(disruption)[Null]
• hus1delta taz1delta
• mre11delta taz1delta
• nse2-SA(C195S,H197A aa) tpz1-K242R(aa)
• pku70delta taz1delta
• pku70delta tpz1-K242R(aa)
• pli1delta tpz1-K242R(aa)
• pmt3delta tpz1-K242R(aa)
• pof8delta rap1delta
• pof8delta rif1delta
• pof8delta taz1delta
• pol1+(wild type)[Overexpression] ssu72delta
• pol1-ts13(470-472 Δaa) ssu72delta
• pot1+(wild type)[Overexpression] rad11-D223Y(aa) taz1delta
• poz1-GBP-E104Q(poz1-GBP-E104Q fusion) rap1deltaPID-GFP(rap1delta(460-505)-GFP tag)
• poz1-R196E(aa) tpz1-I501R(aa)
• poz1-R218E-GBP-E104Q(poz1-R218E-GBP-E104Q fusion) rap1-GFP(rap1-GFP tag)
• poz1-R218E-GBP-R36K,E45K(poz1-R218E-GBP-R36K,E45K fusion) rap1-GFP(rap1-GFP tag)
• poz1-R218E-GBP-R36K(poz1-R218E-GBP-R36K fusion) rap1-GFP(rap1-GFP tag)
• poz1-R218E(aa) rap1-GFP(rap1-GFP tag)
• poz1-cDNA(106-144,347-440 Δnt) rap1-cDNA(96-141,514-596 Δnt) tls1delta
• poz1-cDNA(106-144,347-440 Δnt) tls1delta
• poz1-taz1 rap1delta taz1delta
• poz1deltaNTD-GBP-wt(poz1delta(2-28)-GBP) tpz1-GFP(tpz1-GFP tag)
• poz1delta rad11-D223Y(aa)
• poz1delta rad3-D2249E(aa)
• poz1delta rap1delta taz1delta tpz1-taz1[Knockdown]
• poz1delta tls1delta
• poz1delta tpz1+(wild type)[Overexpression]
• poz1delta tpz1-K242R(aa)
• poz1delta tpz1-K75A(aa)
• rad11-D223Y(aa) rad3-D2249E(aa)
• rad11-D223Y(aa) rap1delta
• rad11-D223Y(aa) rqh1-K547A(aa) taz1delta
• rad11-D223Y(aa) rqh1-K547R(aa) taz1delta
• rad11-D223Y(aa) rqh1delta taz1delta
• rad11-D223Y(aa) stn1-226(I226A,L227A,L229A aa)
• rad17delta set1::Kan(disruption)[Null]
• rad17delta taz1delta
• rad1delta set1::Kan(disruption)[Null]
• rad1delta taz1delta
• rad26delta taz1delta
• rad3delta taz1delta
• rad51delta ssu72delta
• rad52delta rap1-7A(S317A,S329A,S484A,S487A,S496A,S497A,S538A aa)
• rad52delta tpz1-K242R(aa)
• rad9delta set1::Kan(disruption)[Null]
• rad9delta taz1delta
• rap1-cDNA(96-141,514-596 Δnt) tls1delta
• rap1-taz1 rap1delta taz1-Myb(1-551 Δaa)
• rap1delta rif1delta
• rap1delta stn1-226(I226A,L227A,L229A aa)
• rap1delta tls1delta
• rap1delta tpz1-K242R(aa)
• rap1delta tpz1-K75A(aa)
• rif1-PP1(V41A,F43A,I65A,L66A aa) stn1-226(I226A,L227A,L229A aa)
• rif1delta ssu72-C13S(aa)
• rif1delta ssu72delta
• rif1delta stn1-226(I226A,L227A,L229A aa)
• rif1delta tpz1-K242R(aa)
• rqh1delta taz1delta
• set1::Kan(disruption)[Null] tel1delta
• spp1-9(unknown) ssu72delta
• spp2-9(unknown) ssu72delta
• ssu72delta stn1+(wild type)[Overexpression]
• ssu72delta stn1-75(L198S aa)
• taz1delta tel1delta
• taz1delta tls1delta
• taz1delta tpz1-K242R(aa)
• taz1delta tpz1-K75A(aa)
• taz1delta trt1delta
• tel1delta tor1delta
• tel1delta tpz1-K242R(aa)

FYPO:0004985 - entangled telomeres during vegetative growth

References:

• PMID:21098121
• PMID:22313747

Genes:

• pot1 (SPAC26H5.06)
• rqh1 (SPAC2G11.12)
• trt1 (SPBC29A3.14c)

Genotypes:

• pot1delta rqh1-K547A(aa)
• rqh1-K547A(aa) trt1delta

FYPO:0005434 - globally decreased meiotic recombination

References:

• PMID:15654094

Genes:

• mre11 (SPAC13C5.07)
• rad16 (SPCC970.01)
• rad50 (SPAC1556.01c)
• rec12 (SPAC17A5.11)

Genotypes:

• mre11-D65N(aa)/mre11-D65N(aa) rec12delta/rec12delta
• rad16delta/rad16delta rec12-152(unknown)/rec12-152(unknown)
• rad50S(K81I aa)/rad50S(K81I aa) rec12-152(unknown)/rec12-152(unknown)

FYPO:0005432 - globally decreased mitotic recombination

References:

• PMID:31584934

Genes:

• hht2 (SPBC8D2.04)
• rqh1 (SPAC2G11.12)

Genotypes:

• hht2-H113D(H114D aa)[Knockdown] rqh1delta

FYPO:0008338 - increased 3' end uridylation of non-polyadenylated RNA

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)
• dis32 (SPAC2C4.07c)
• lsm1 (SPBC3D6.08c)
• ski2 (SPCC550.03c)

Genotypes:

• cid1delta dis32delta lsm1delta
• cid1delta lsm1delta
• cid1delta lsm1delta ski2delta

FYPO:0002913 - increased antisense RNA transcription

References:

• PMID:31837996
• PMID:32496538

Genes:

• brl2 (SPCC970.10c)
• cdk9 (SPBC32H8.10)
• hrp3 (SPAC3G6.01)
• htb1 (SPCC622.09)
• pob3 (SPBC609.05)
• set2 (SPAC29B12.02c)
• spt5 (SPAC23C4.19)

Genotypes:

• brl2delta cdk9-T120G(aa)
• cdk9-T120G(aa) hrp3delta
• cdk9-T120G(aa) htb1-K119R(K120R aa)
• cdk9-T120G(aa) htb1-K119R(K120R aa) spt5-CTD-T1A(7)(801-990,S800SGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGS)
• cdk9-T120G(aa) set2delta
• cdk9-T120G(aa) spt5-CTD-T1A(7)(801-990,S800SGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGS)
• hrp3delta htb1-K119R(K120R aa)
• htb1-K119R(K120R aa) pob3delta

FYPO:0000565 - increased cellular respiration

References:

• PMID:20485751

Genes:

• btn1 (SPAC607.09c)
• leu1 (SPBC1A4.02c)

Genotypes:

• btn1delta leu1-32(G46E aa)

FYPO:0004011 - increased degradation of ribosomal proteins during vegetative growth

References:

• PMID:2839305

Genes:

• top1 (SPBC1703.14c)
• top2 (SPBC1A4.03c)

Genotypes:

• top1-701(unknown) top2-191(unknown)

FYPO:0000167 - increased DNA recombination at mitotic DNA replication fork barriers

References:

• PMID:31149897

Genes:

• elg1 (SPBC947.11c)
• fbh1 (SPBC336.01)

Genotypes:

• elg1delta fbh1delta

FYPO:0005407 - increased DNA recombination at telomere during nitrogen starvation

References:

• PMID:31980821

Genes:

• bqt4 (SPBC19C7.10)
• ter1 (SPNCRNA.214)

Genotypes:

• bqt4delta ter1delta

FYPO:0005406 - increased DNA recombination at telomere following meiotic cell cycle

References:

• PMID:12930956

Genes:

• pku80 (SPBC543.03c)
• rad50 (SPAC1556.01c)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)

Genotypes:

• pku80delta rad50delta
• pku80delta rad51delta
• pku80delta rad52delta

FYPO:0004251 - increased DNA resection during replication fork processing

References:

• PMID:29697047

Genes:

• crb2 (SPBC342.05)
• exo1 (SPBC29A10.05)
• rev7 (SPBC12D12.09)
• rqh1 (SPAC2G11.12)

Genotypes:

• crb2delta exo1delta
• crb2delta rqh1delta
• exo1delta rev7delta

FYPO:0003584 - increased double-strand break repair via nonhomologous end joining

References:

• PMID:15226425
• PMID:19798055
• PMID:25533340
• PMID:27098497

Genes:

• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• hta1 (SPCC622.08c)
• hta2 (SPAC19G12.06c)
• rqh1 (SPAC2G11.12)
• spd1 (SPAC29B12.03)
• wdr70 (SPAC343.17c)
• xlf1 (SPCC24B10.14c)

Genotypes:

• ctp1delta xlf1.AA(T180A,S192A aa)
• exo1delta rqh1delta
• hta1-S129A(aa) hta2-S128A(aa)
• spd1delta wdr70delta

FYPO:0005618 - increased duration of meiotic recombination double-strand break repair

References:

• PMID:18378696

Genes:

• ctp1 (SPCC338.08)
• mre11 (SPAC13C5.07)

Genotypes:

• ctp1delta mre11delta

FYPO:0006157 - increased duration of protein oxidation during vegetative growth

References:

• PMID:28640807

Genes:

• grx1 (SPAC4F10.20)
• trx1 (SPAC7D4.07c)
• txl1 (SPBC577.08c)

Genotypes:

• grx1delta trx1delta
• trx1delta txl1delta

FYPO:0006718 - increased duration of protein phosphorylation during cellular response to osmotic stress

References:

• PMID:28515144

Genes:

• gpd1 (SPBC215.05)
• gpd2 (SPAC23D3.04c)

Genotypes:

• gpd1delta gpd2delta

FYPO:0006345 - increased duration of protein phosphorylation during nitrogen starvation

References:

• PMID:29199950

Genes:

• gtr1 (SPBC337.13c)
• iml1 (SPBC26H8.04c)
• tor2 (SPBC216.07c)

Genotypes:

• gtr1delta tor2-E2221K(aa)
• iml1delta tor2-E2221K(aa)

FYPO:0005659 - increased frequency of meiotic crossover associated with gene conversion

References:

• PMID:25414342

Genes:

• dmc1 (SPAC8E11.03c)
• fml1 (SPAC9.05)
• rad55 (SPAC3C7.03c)
• rlp1 (SPBC1685.11)
• rqh1 (SPAC2G11.12)
• sfr1 (SPBC28F2.07)

Genotypes:

• dmc1delta fml1delta
• dmc1delta fml1delta rlp1delta rqh1delta
• dmc1delta fml1delta rqh1delta
• fml1delta rad55delta
• fml1delta rad55delta rqh1delta
• fml1delta rlp1delta rqh1delta
• fml1delta rqh1delta
• fml1delta rqh1delta sfr1delta
• fml1delta sfr1delta
• rad55delta rqh1delta
• rlp1delta rqh1delta
• rqh1delta sfr1delta

FYPO:0005611 - increased H4-K20 dimethylation at double-strand break site during vegetative growth

References:

• PMID:27098497

Genes:

• htb1 (SPCC622.09)
• spd1 (SPAC29B12.03)
• wdr70 (SPAC343.17c)

Genotypes:

• htb1-K119R(K120R aa) spd1delta
• spd1delta wdr70delta

FYPO:0006872 - increased histone H2A phosphorylation during cellular response to ionizing radiation

References:

• PMID:29851556

Genes:

• mre11 (SPAC13C5.07)
• nbs1 (SPBC6B1.09c)
• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)

Genotypes:

• mre11-H134S(aa) nbs1delta rad3delta tel1+(wild type)[Overexpression]
• mre11-TBD(Nbs1(554-613)-Mre11-C) nbs1delta rad3delta
• nbs1-c60-delta(554-613 Δaa) rad3delta tel1+(wild type)[Overexpression]
• nbs1delta rad3delta tel1+(wild type)[Overexpression]
• rad3delta tel1+(wild type)[Overexpression]

FYPO:0002596 - increased histone H2A phosphorylation during vegetative growth

References:

• PMID:29851556
• PMID:32341083

Genes:

• cds1 (SPCC18B5.11c)
• mcm4 (SPCC16A11.17)
• mre11 (SPAC13C5.07)
• mus81 (SPCC4G3.05c)
• nbs1 (SPBC6B1.09c)
• rad3 (SPBC216.05)
• rad50 (SPAC1556.01c)
• tel1 (SPCC23B6.03c)

Genotypes:

• cds1-FHA(S78A,H81A aa) mcm4-tstd(Ub-DHFRts-mcm4)
• cds1delta mcm4-tstd(Ub-DHFRts-mcm4)
• mcm4-tstd(Ub-DHFRts-mcm4) mus81-T275A(aa)
• mre11delta rad3delta tel1+(wild type)[Overexpression]
• nbs1-c60-delta(554-613 Δaa) rad3delta tel1+(wild type)[Overexpression]
• nbs1delta rad3delta tel1+(wild type)[Overexpression]
• rad3delta rad50-I1192W(aa) tel1+(wild type)[Overexpression]
• rad3delta tel1+(wild type)[Overexpression]

FYPO:0010012 - increased histone H2B-K33 acetylation during vegetative growth

References:

• PMID:31262821

Genes:

• clr3 (SPBC800.03)
• clr6 (SPBC36.05c)

Genotypes:

• clr3delta clr6-1(G269D aa)

FYPO:0006815 - increased histone H3-K14 acetylation at centromere inner repeat during vegetative growth

References:

• PMID:30652128

Genes:

• clr4 (SPBC428.08c)
• mlo3 (SPBC1D7.04)

Genotypes:

• clr4delta mlo3delta

FYPO:0000966 - increased histone H3-K14 acetylation at centromere outer repeat during vegetative growth

References:

• PMID:30573453
• PMID:30652128

Genes:

• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• gcn5 (SPAC1952.05)
• mlo3 (SPBC1D7.04)

Genotypes:

• clr3delta gcn5delta
• clr4delta mlo3delta

FYPO:0005518 - increased histone H3-K14 acetylation at protein coding gene during vegetative growth

References:

• PMID:22990236
• PMID:32496538

Genes:

• cdk9 (SPBC32H8.10)
• hrp3 (SPAC3G6.01)
• htb1 (SPCC622.09)
• set2 (SPAC29B12.02c)

Genotypes:

• cdk9-T120G(aa) htb1-K119R(K120R aa)
• hrp3delta set2delta

FYPO:0007634 - increased histone H3-K14 acetylation at rDNA during vegetative growth

References:

• PMID:40132111

Genes:

• cbp1 (SPBC1105.04c)
• dcr1 (SPCC188.13c)

Genotypes:

• cbp1delta dcr1delta

FYPO:0007633 - increased histone H3-K14 acetylation at silent mating-type cassette during vegetative growth

References:

• PMID:39096900

Genes:

• mst2 (SPAC17G8.13c)
• snf22 (SPCC1620.14c)

Genotypes:

• mst2-CDx2(Chromodomain fusion) snf22delta

FYPO:0006263 - increased histone H3-K36 trimethylation during vegetative growth

References:

• PMID:26804021

Genes:

• hta1 (SPCC622.08c)
• hta2 (SPAC19G12.06c)

Genotypes:

• hta1-S121A(S122A aa) hta2-S121A(S122A aa)

FYPO:0002331 - increased histone H3-K4 dimethylation at centromere outer repeat during vegetative growth

References:

• PMID:16127433

Genes:

• cul4 (SPAC3A11.08)

Genotypes:

• cul4-1(marker gene insertion at 3'-UTR) cul4-K680R(aa)

FYPO:0005225 - increased histone H3-K4 dimethylation during vegetative growth

References:

• PMID:17371846
• PMID:26804021

Genes:

• hta1 (SPCC622.08c)
• hta2 (SPAC19G12.06c)
• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)

Genotypes:

• hta1-S121A(S122A aa) hta2-S121A(S122A aa)
• lsd1-ao(K603A,K604A aa) lsd2-ao(K823A,K824A aa)

FYPO:0006681 - increased histone H3-K9 acetylation at centromere inner repeat during vegetative growth

References:

• PMID:30652128

Genes:

• clr4 (SPBC428.08c)
• mlo3 (SPBC1D7.04)

Genotypes:

• clr4delta mlo3delta

FYPO:0006814 - increased histone H3-K9 acetylation at centromere outer repeat during vegetative growth

References:

• PMID:30573453
• PMID:30652128

Genes:

• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• gcn5 (SPAC1952.05)
• mlo3 (SPBC1D7.04)
• sir2 (SPBC16D10.07c)

Genotypes:

• clr3delta gcn5delta
• clr4delta mlo3delta
• gcn5delta sir2delta

FYPO:0004347 - increased histone H3-K9 acetylation at protein coding gene during vegetative growth

References:

• PMID:22990236
• PMID:32496538

Genes:

• cdk9 (SPBC32H8.10)
• hrp3 (SPAC3G6.01)
• htb1 (SPCC622.09)
• set2 (SPAC29B12.02c)

Genotypes:

• cdk9-T120G(aa) htb1-K119R(K120R aa)
• hrp3delta set2delta

FYPO:0000887 - increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

• PMID:27334362
• PMID:27648579
• PMID:30652128
• PMID:32295063

Genes:

• ago1 (SPCC736.11)
• epe1 (SPCC622.16c)
• hht3 (SPBC1105.11c)
• lem2 (SPAC18G6.10)
• lnp1 (SPCC1620.07c)
• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)

Genotypes:

• ago1delta epe1delta
• epe1delta hht3-K9M(K10M aa)
• lem2delta lnp1+(wild type)[Overexpression]
• lsd1-ao(K603A,K604A aa) lsd2-ao(K823A,K824A aa)

FYPO:0006369 - increased histone H3-K9 dimethylation at heterochromatin domain during vegetative growth

References:

• PMID:29214404
• PMID:41316862

Genes:

• elp1 (SPBC36.07)
• leo1 (SPBC13E7.08c)
• rpb2 (SPAC23G3.01)
• rpt4 (SPCC1682.16)
• rrp6 (SPAC1F3.01)

Genotypes:

• elp1delta rpb2-m203(N44Y aa) rrp6delta
• leo1delta rpt4-1(D249A aa)

FYPO:0006373 - increased histone H3-K9 dimethylation at heterochromatin island during vegetative growth

References:

• PMID:29214404

Genes:

• leo1 (SPBC13E7.08c)
• rpt4 (SPCC1682.16)

Genotypes:

• leo1delta rpt4-1(D249A aa)

FYPO:0006268 - increased histone H3-K9 dimethylation at protein coding gene during vegetative growth

References:

• PMID:39094565

Genes:

• epe1 (SPCC622.16c)
• mst2 (SPAC17G8.13c)

Genotypes:

• epe1-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron) mst2-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron)
• epe1-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron) mst2delta
• epe1delta mst2delta

FYPO:0006074 - increased histone H3-K9 dimethylation at rDNA during vegetative growth

References:

• PMID:41258116

Genes:

• tor1 (SPBC30D10.10c)
• tor2 (SPBC216.07c)

Genotypes:

• tor1delta tor2-L2048S(aa)

FYPO:0006987 - increased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

References:

• PMID:32295063

Genes:

• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)

Genotypes:

• lsd1-ao(K603A,K604A aa) lsd2-ao(K823A,K824A aa)

FYPO:0006361 - increased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

• PMID:17371846
• PMID:29214404
• PMID:32295063

Genes:

• ago1 (SPCC736.11)
• leo1 (SPBC13E7.08c)
• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)
• rpt4 (SPCC1682.16)

Genotypes:

• ago1delta lsd1-ao(K603A,K604A aa)
• leo1delta rpt4-1(D249A aa)
• lsd1-ao(K603A,K604A aa) lsd2-ao(K823A,K824A aa)

FYPO:0000873 - increased histone H3-K9 dimethylation during vegetative growth

References:

• PMID:25774602

Genes:

• epe1 (SPCC622.16c)
• mst2 (SPAC17G8.13c)
• swi6 (SPAC664.01c)

Genotypes:

• epe1delta mst2delta swi6delta

FYPO:0006077 - increased histone H3-K9 methylation at rDNA during vegetative growth

References:

• PMID:28541282
• PMID:40132111

Genes:

• cbp1 (SPBC1105.04c)
• cid14 (SPAC12G12.13c)
• rdp1 (SPAC6F12.09)
• rpb1 (SPBC28F2.12)
• rpb2 (SPAC23G3.01)

Genotypes:

• cbp1delta rpb1-CTD-S7A(r5-r29)(aa)
• cbp1delta rpb2-m203(N44Y aa)
• cid14delta rdp1+(wild type)[Overexpression]

FYPO:0008327 - increased histone H3-K9 trimethylation at heterochromatin island during vegetative growth

References:

• PMID:39094565
• PMID:39096900

Genes:

• epe1 (SPCC622.16c)
• mst2 (SPAC17G8.13c)
• rsc1 (SPBC4B4.03)
• snf22 (SPCC1620.14c)

Genotypes:

• epe1-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron) mst2-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron)
• epe1-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron) mst2delta
• rsc1delta snf22delta

FYPO:0008326 - increased histone H3-K9 trimethylation at protein coding gene during vegetative growth

References:

• PMID:39094565

Genes:

• epe1 (SPCC622.16c)
• mst2 (SPAC17G8.13c)

Genotypes:

• epe1-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron) mst2-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron)
• epe1-3XFLAG-AID(C-term tag with 3XFLAG bridging to auxin-inducible degron) mst2delta

FYPO:0010053 - increased histone H4-K12 acetylation at subtelomeric chromatin knob during vegetative growth

References:

• PMID:40520116

Genes:

• nts1 (SPCC24B10.19c)
• set2 (SPAC29B12.02c)

Genotypes:

• nts1delta set2delta

FYPO:0004324 - increased histone H4-K16 acetylation at centromere central core during vegetative growth

References:

• PMID:26369364

Genes:

• hht1 (SPAC1834.04)
• hht2 (SPBC8D2.04)
• hht3 (SPBC1105.11c)

Genotypes:

• hht1delta hht2-S86A,S87A(S87A,S88A aa) hht3delta

FYPO:0010052 - increased histone H4-K5 acetylation at subtelomeric chromatin knob during vegetative growth

References:

• PMID:40520116

Genes:

• nts1 (SPCC24B10.19c)
• set2 (SPAC29B12.02c)

Genotypes:

• nts1delta set2delta

FYPO:0008305 - increased inter-sister chromatid meiotic recombination

References:

• PMID:39174851

Genes:

• cdc13 (SPBC582.03)
• cdc2 (SPBC11B10.09)

Genotypes:

• cdc13+(wild type)/cdc13+(wild type) cdc13+(wild type)/cdc13+(wild type)
• cdc2+(wild type)/cdc2+(wild type) cdc2+(wild type)/cdc2+(wild type)

FYPO:0008113 - increased intron retention

References:

• PMID:34706246

Genes:

• prp2 (SPBC146.07)
• ypt7 (SPBC405.04c)

Genotypes:

• prp2-C387Y(aa) ypt7-5'SSmut1(G478T nt)
• prp2-C387Y(aa) ypt7-5'SSmut2(G483A nt)
• prp2-C387Y(aa) ypt7-5'SSmut3(A476C,T477A,G483A nt)
• prp2-C387Y(aa) ypt7-BPmut(T532C nt)

FYPO:0000473 - increased mitotic recombination

References:

• PMID:17515930
• PMID:28922417

Genes:

• brc1 (SPBC582.05c)
• pnk1 (SPAC23C11.04c)
• rad9 (SPAC664.07c)
• srs2 (SPAC4H3.05)

Genotypes:

• brc1delta pnk1delta
• rad9-T225C(aa) srs2delta

FYPO:0005868 - increased mitotic recombination at rDNA

References:

• PMID:19158664

Genes:

• rad52 (SPAC30D11.10)
• smc6 (SPCC5E4.06)
• swi6 (SPAC664.01c)

Genotypes:

• rad52delta smc6-74(A151T aa)
• rad52delta smc6-X(R706C aa)
• smc6-74(A151T aa) swi6delta
• smc6-X(R706C aa) swi6delta

FYPO:0006280 - increased mitotic recombination with crossover formation at centromere

References:

• PMID:28977643

Genes:

• fml1 (SPAC9.05)
• mhf1 (SPBC2D10.16)

Genotypes:

• fml1delta mhf1delta

FYPO:0004166 - increased oxygen consumption during vegetative growth

References:

• PMID:38360270

Genes:

• erd2 (SPBP8B7.22)
• ire1 (SPAC167.01)

Genotypes:

• erd2delta ire1delta

FYPO:0005041 - increased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth

References:

• PMID:22144909

Genes:

• mcs4 (SPBC887.10)
• mei2 (SPAC27D7.03c)
• ste11 (SPBC32C12.02)
• win1 (SPAC1006.09)
• wis4 (SPAC9G1.02)

Genotypes:

• mcs4delta mei2-SATA(S438A,T527A aa)
• mei2-SATA(S438A,T527A aa) ste11delta
• mei2-SATA(S438A,T527A aa) win1delta
• mei2-SATA(S438A,T527A aa) win1delta wis4delta
• mei2-SATA(S438A,T527A aa) wis4delta

FYPO:0004200 - increased protein degradation during mitotic G1 phase

References:

• PMID:9303310

Genes:

• cdc10 (SPBC336.12c)
• cdc13 (SPBC582.03)

Genotypes:

• cdc10-129(T429A aa) cdc13+(wild type)[Knockdown]

FYPO:0002277 - increased protein degradation during nitrogen starvation

References:

• PMID:32361273

Genes:

• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)
• par1 (SPCC188.02)

Genotypes:

• cig1delta cig2delta
• cig1delta cig2delta par1delta

FYPO:0006837 - increased protein dephosphorylation during cytokinesis

References:

• PMID:30332655

Genes:

• ppb1 (SPBP4H10.04)
• pxl1 (SPBC4F6.12)

Genotypes:

• GFP-pxl1N-ppb1(GFP-pxl1(1-257)-ppb1) ppb1delta pxl1delta

FYPO:0006115 - increased protein oxidation during mitotic S phase

References:

• PMID:28640807

Genes:

• grx1 (SPAC4F10.20)
• trx1 (SPAC7D4.07c)
• txl1 (SPBC577.08c)

Genotypes:

• grx1delta trx1delta
• grx1delta trx1delta txl1delta
• trx1delta txl1delta

FYPO:0000219 - increased protein oxidation during vegetative growth

References:

• PMID:24268782

Genes:

• trx1 (SPAC7D4.07c)
• txl1 (SPBC577.08c)

Genotypes:

• trx1delta txl1delta

FYPO:0003862 - increased protein oxidation in stationary phase

References:

• PMID:17986764
• PMID:18162174

Genes:

• gcs1 (SPAC22F3.10c)
• sod1 (SPAC821.10c)
• trx1 (SPAC7D4.07c)
• trx2 (SPBC12D12.07c)

Genotypes:

• gcs1delta sod1delta
• trx1delta trx2delta

FYPO:0002680 - increased protein phosphorylation

References:

• PMID:19625445
• PMID:21095590
• PMID:29899453
• PMID:31644361
• PMID:31911490
• PMID:37572670

Genes:

• cdk9 (SPBC32H8.10)
• cdr1 (SPAC644.06c)
• cdr2 (SPAC57A10.02)
• cpc2 (SPAC6B12.15)
• dfp1 (SPCC550.13)
• dis2 (SPBC776.02c)
• fcp1 (SPAC19B12.05c)
• hsk1 (SPBC776.12c)
• lsk1 (SPAC2F3.15)
• mcs4 (SPBC887.10)
• pmp1 (SPBC1685.01)
• pyp1 (SPAC26F1.10c)
• rnc1 (SPCC757.09c)
• sty1 (SPAC24B11.06c)
• wis1 (SPBC409.07c)

Genotypes:

• cdk9-T120G(aa) dis2-11(R245Q aa)
• cdr1+(wild type)[Overexpression] cdr1delta cdr2delta
• cdr1delta cdr2+(wild type)[Overexpression] cdr2delta
• cpc2delta pmp1delta
• cpc2delta pyp1delta
• dfp1+(wild type)[Overexpression] hsk1+(wild type)[Overexpression]
• fcp1-R223K(aa) lsk1-F353G(aa)
• mcs4delta sty1-tpx1(Sty1-Tpx1@sty1)
• pyp1delta rnc1delta
• sty1-tpx1-C48S(Sty1-Tpx1-C48S@sty1) wis1-AA(S469A,T473A aa)

FYPO:0005480 - increased protein phosphorylation during cellular response to arsenite ion

References:

• PMID:16087744

Genes:

• pyp1 (SPAC26F1.10c)
• win1 (SPAC1006.09)
• wis4 (SPAC9G1.02)

Genotypes:

• pyp1delta win1-1(unknown) wis4delta

FYPO:0004333 - increased protein phosphorylation during cellular response to hydrogen peroxide

References:

• PMID:22139357

Genes:

• ptc1 (SPCC4F11.02)
• ptc2 (SPCC1223.11)
• ptc3 (SPAC2G11.07c)
• ptc4 (SPAC4A8.03c)
• wis1 (SPBC409.07c)

Genotypes:

• ptc1delta ptc2delta ptc3delta
• ptc4delta wis1-DD(S469D,T473D aa)

FYPO:0002096 - increased protein phosphorylation during cellular response to hydroxyurea

References:

• PMID:10559981
• PMID:15155581
• PMID:15173168
• PMID:31538680

Genes:

• aph1 (SPCC4G3.02)
• cds1 (SPCC18B5.11c)
• chk1 (SPCC1259.13)
• crb2 (SPBC342.05)

Genotypes:

• aph1delta cds1-myc(C-terminal Myc tagged)
• cds1+(wild type)[Overexpression] cds1-D312E(aa)
• cds1delta chk1delta
• cds1delta crb2delta

FYPO:0006871 - increased protein phosphorylation during cellular response to ionizing radiation

References:

• PMID:29851556

Genes:

• nbs1 (SPBC6B1.09c)
• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)