Phenotype ontology term - FYPO:0000146 - abnormal chromatin silencing at centromere
Term summary
- ID
- FYPO:0000146
- Name
- abnormal chromatin silencing at centromere
- Ontology or CV name
- Phenotype
- Definition
- A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing is abnormal in centromeric regions. Chromatin silencing is the observed effect of processes that repress transcription in a region of the genome that is normally assembled into heterochromatin or CENP-A-containing chromatin (the latter is found at the centromere central core).
Annotation
Multi-locus phenotype
References:
Genes:
Genotypes:
- ago1-F276A(aa) chp1-E23V(aa)
- ago1-F276A(aa) chp1-V24M(aa)
- ago1delta clr4-IDR-Mut1(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q aa)
- ago1delta clr4-IDR-Mut2(K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
- ago1delta clr4-IDR-Mut3(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q,K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
- chp1-E23V(aa) tas3-W265A,G266A(aa)
- cid14-DADA(D298A,D300A aa)[Overexpression] cid14delta
- cul4-1(marker gene insertion at 3'-UTR) cul4-K680R(aa)
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
- SPBTRNALYS.06+(wild type)[Overexpression] elp1delta rpb2-m203(N44Y aa)
- ago1-intronless prp10-1(A1050V,S1058F aa)
- ago1delta elp1delta rpb2-m203(N44Y aa)
- ago1delta iec1delta
- ago1delta ies4delta
- ago1delta iss1-deltaC38(327-344 Δaa)
- ago1delta leo1::Hermes(disruption)[Null]
- ago1delta lsd1-ao(K603A,K604A aa)
- ago1delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
- ago1delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
- ago1delta rap1delta
- alp13delta hrp3delta
- bdf2-BD1delta(234-336 Δaa) dcr1delta
- ccq1delta dcr1delta
- chp1delta chp2delta
- chp1delta chp2delta swi6delta
- chp1delta hht1-Y41F(Y42F aa) hht2-Y41F(Y42F aa) hht3-Y41F(Y42F aa)
- chp1delta swi6delta
- chp2delta swi6delta
- clr1-5(unknown) clr6-1(G269D aa)
- clr1delta lem2delta
- clr3+(wild type)[Overexpression] mcl1-101(P493S,L763F,A767V aa)
- clr3+(wild type)[Overexpression] mcl1-101(P493S,L763F,A767V aa) sir2+(wild type)[Overexpression]
- clr3-735(D232N aa) clr6-1(G269D aa)
- clr3delta dcr1delta
- clr3delta dcr1delta poz1delta
- clr3delta dcr1delta rap1delta
- clr3delta dcr1delta swi6+(wild type)[Overexpression]
- clr3delta lem2delta
- clr3delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
- clr3delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
- clr3delta pob3delta
- clr3delta poz1delta
- clr3delta rap1delta
- clr3delta swi6+(wild type)[Overexpression]
- clr4+(wild type)[Overexpression] ers1-C62(S234P aa)
- clr4-F449Y(aa) spt16-1(unknown)[Knockdown]
- clr4-R320H(aa) hrp3delta
- clr4delta dcr1delta poz1delta
- clr4delta elp1delta rpb2-m203(N44Y aa)
- clr4delta poz1delta
- clr4delta rap1delta
- clr4delta swi6+(wild type)[Overexpression]
- clr6-1(G269D aa)[Knockdown] lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
- clr6-1(G269D aa)[Knockdown] lsd2-deltaC(1165-1235 Δaa)[Knockdown]
- csi1delta lem2delta
- ctu2delta rpb2-m203(N44Y aa)
- dcr1delta dpb4delta
- dcr1delta elp1delta rpb2-m203(N44Y aa)
- dcr1delta hrp1delta
- dcr1delta mcm2-2a(Y80A,Y89A aa)
- dcr1delta pot1delta
- dcr1delta poz1delta sir2delta
- dcr1delta sde2delta
- dcr1delta sir2delta
- dcr1delta sir2delta swi6+(wild type)[Overexpression]
- dcr1delta tpz1delta
- dcr1delta trt1delta
- ddb1delta spd1delta
- dfp1-3A(P448A,V450A,I452A aa) swi6delta
- dfp1-CFP-2CD(dfp1-CFP-swi6(69-215)-swi6(69-215)) swi6delta
- dpb3delta sir2delta
- dpb4delta dri1delta
- dpb4delta sir2delta
- dsh1delta lem2delta
- elp1delta rdp1delta rpb2-m203(N44Y aa)
- elp3-CC(C106A,C109A aa) rpb2-m203(N44Y aa)
- elp3delta rpb2-m203(N44Y aa)
- elp5delta rpb2-m203(N44Y aa)
- epe1+(wild type)[Overexpression] gcn5delta
- epe1+(wild type)[Overexpression] sgf11delta
- epe1+(wild type)[Overexpression] spt3delta
- epe1+(wild type)[Overexpression] spt8delta
- epe1+(wild type)[Overexpression] tra1delta
- epe1+(wild type)[Overexpression] ubp8delta
- epe1-H297A(aa)[Overexpression] gcn5delta
- epe1delta lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
- epe1delta lsd2-deltaC(1165-1235 Δaa)[Knockdown]
- ers1-C62(S234P aa) hrr1+(wild type)[Overexpression]
- fft3delta spt16-1(unknown)[Knockdown]
- hht1-K14R(K15R aa) hht3-K9M(K10M aa)
- hht1-S10D(S11D aa) hht3-K9M(K10M aa)
- hht2+(wild type)[Overexpression] hht3-K9M(K10M aa)
- hrr1-intronless prp10-1(A1050V,S1058F aa)
- lem2delta nur1delta
- lsd1-deltaHMG(841-1000 Δaa)[Knockdown] sir2delta
- lsd2-deltaC(1165-1235 Δaa)[Knockdown] sir2delta
- mcl1-101(P493S,L763F,A767V aa) sir2+(wild type)[Overexpression]
- mkt1delta sir2delta
- msc1delta swi6delta
- poz1delta swi6delta
- rad25+(wild type)[Overexpression] rss1delta
- rad25delta rss1delta
- raf1+(wild type)[Overexpression] set3delta
- rap1delta rdp1delta
- rap1delta swi6delta
- rpb2-m203(N44Y aa) rpb9delta
- rpb2-m203(N44Y aa) tfs1delta
- rss1+(wild type)[Overexpression] sir2delta
- rss1delta sir2delta
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
Single locus phenotype
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
- ago1-D580A(aa)
- ago1-F276A(aa)
- ago1delta
- arb1delta
- arb2delta
- asf1-1(C30F,D54N aa)
- caf1delta
- clr4-F449Y(aa)
- clr4-I418P(aa)
- clr4-IDR-Mut1(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q aa)
- clr4-IDR-Mut2(K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
- clr4-IDR-Mut3(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q,K109Q,K110Q,K113Q,K114Q,K122Q,R123Q,R126Q,K127Q aa)
- clr4delta
- cul4-1(marker gene insertion at 3'-UTR)
- cut3-477(S1147P aa)
- hht2-K4R(K5R aa)
- mot2delta
- pob3delta
- pst1-1(W1305*)
- set1delta
- stc1-deltaZF1+2(32-126 Δaa)
- stc1-deltaZF1(32-84 Δaa)
- stc1-deltaZF2(89-126 Δaa)
- stc1delta
References:
Genes:
Genotypes:
- SPAC144.05::Tn-seq(irc20::Tn-seq)
- SPAC24B11.05::Tn-seq
- SPAC30D11.14c::Tn-seq
- SPAC3H8.08c::Tn-seq
- SPAC56E4.03::Tn-seq
- SPAC694.04c::Tn-seq
- SPAC806.06c::Tn-seq
- SPAC9.02c::Tn-seq
- SPAP8A3.07c::Tn-seq
- SPBC11C11.05::Tn-seq(knh1::Tn-seq)
- SPBC28E12.04::Tn-seq(cbp7::Tn-seq)
- SPBC30D10.14::Tn-seq
- SPBC577.03c::Tn-seq
- SPCC569.05c::Tn-seq
- SPCC613.01::Tn-seq_
- SPCC63.06::Tn-seq
- abo1delta
- abz2::Tn-seq
- ago1-3A(F276A,Y513A,K517A aa)
- ago1-D580A(aa)
- ago1-D651A(aa)
- ago1-F276A(aa)
- ago1-H788A(aa)
- ago1::Tn-seq
- ago1delta
- ags1::Tn-seq
- alp13delta
- ani1::Tn-seq
- ani2::Tn-seq
- any2::Tn-seq
- arb1delta
- arb2delta
- aro1::Tn-seq
- asf1-1(C30F,D54N aa)
- byr3::Tn-seq
- caf1delta
- cat1::Tn-seq
- cat1delta
- cbp3::Tn-seq
- cbr1::Tn-seq
- cdr1::Tn-seq
- cdr2::Tn-seq
- cdt2delta
- chp1(1-409)(410-960 Δaa)
- chp1-E23V,V24M(aa)
- chp1-V24R(aa)
- chp1-W44A(aa)
- chp1-alpha-mut1(KKRKK71NEHG aa)
- chp1::Tn-seq
- chp1delta
- chp1deltaCD(2-79)(aa)
- chp1deltaCD(20-75)(aa)
- chp2-TAP(C-terminal TAP tagging)
- chp2delta
- cid12delta
- cki3::Tn-seq
- clr1-5(unknown)
- clr1delta
- clr2::Tn-seq
- clr2delta
- clr3-735(D232N aa)
- clr3delta
- clr4-3FA(F256A,F310A,F427A aa)
- clr4-F449Y(aa)
- clr4-GS253(D253G,P254G,N255S,F256G aa)
- clr4-Y451N(aa)
- clr4-alpha-mut(KRRKR58NEHG aa)
- clr4delta
- clr6-1(G269D aa)
- cop1::Tn-seq
- cos1-17(V233A aa)
- cos1-22(A574D aa)
- cos1-38(G622E aa)
- cos1-7(G242R aa)
- cos1-86(Q765*)
- cox1102::Tn-seq
- cpc2::Tn-seq
- csn1delta
- csn2delta
- cul4-2(unknown)
- cul4-3(unknown)
- cul4delta
- cwf10-1(C324Y aa)
- cwf11::Tn-seq
- cwf2::Tn-seq
- cyc2::Tn-seq
- dbl8::Tn-seq
- dcr1-SHSS(C1275S,C1350S,C1352S aa)
- dcr1::Tn-seq
- dcr1delta
- ddb1delta
- dis3-54(P509L aa)
- dpb3-6A(L10A,I18A,L35A,F43A,L47A,F80A aa)
- dpb3::Tn-seq
- dpb3delta
- dpb4-deltaHF(17-80 Δaa)
- dpb4delta
- dri1delta
- drp1::Tn-seq
- dsh1::Tn-seq
- dsh1delta
- dus3::Tn-seq
- dus3delta
- elp3-CC(C106A,C109A aa)
- elp3delta
- elp5delta
- enp1::Tn-seq
- epe1+(wild type)[Overexpression]
- epe1-H297A(aa)[Overexpression]
- epe1-deltaFVI(566-577 Δaa)
- epe1delta
- ers1-C62(S234P aa)
- ers1::Tn-seq
- ers1delta
- etr1::Tn-seq
- faf1::Tn-seq
- fep1::Tn-seq
- fft3delta
- fip1::Tn-seq
- fub2::Tn-seq
- fyu1::Tn-seq
- gar2::Tn-seq
- gly1::Tn-seq
- grt1::Tn-seq
- hca4::Tn-seq
- hht1-K14R(K15R aa)
- hht1-K9M(K10M aa)
- hht2-K9M(K10M aa)
- hht3-K9M(K10M aa)
- hht3-K9R(K10R aa)
- hip1delta
- hip3delta
- hip4delta
- hpt1::Tn-seq
- hpt1delta
- hrp1::Tn-seq
- hrp1delta
- hsp-tev-2(hsp90-tev-2)
- hsp104delta
- hsp90-A4(R33C aa)
- hsp90-G84C(aa)
- hst2delta
- hst4delta
- hta2::Tn-seq
- idh2::Tn-seq
- ino80::Tn-seq
- iss1-deltaC38(327-344 Δaa)
- iss1::Tn-seq
- its8::Tn-seq
- jmj3::Tn-seq
- kap104::Tn-seq
- kap111::Tn-seq
- kap114::Tn-seq
- kin1::Tn-seq
- krs1::Tn-seq
- lem2delta
- lid2-H542A(aa)
- lid2::Tn-seq
- lkh1::Tn-seq
- lsd1-deltaHMG(841-1000 Δaa)[Knockdown]
- lsd2-deltaC(1165-1235 Δaa)[Knockdown]
- mak2::Tn-seq
- mak2delta
- mas5delta
- mcl1-101(P493S,L763F,A767V aa)
- mcl1delta
- mcm2-2a(Y80A,Y89A aa)
- mcm2-G221V(aa)
- mcs2::Tn-seq
- mdm31::Tn-seq
- med1::Tn-seq
- med20::Tn-seq
- med20delta
- mef1::Tn-seq
- mex67::Tn-seq
- mit1-K587A(aa)
- mit1-deltaCD(unknown)
- mit1::Tn-seq
- mit1delta
- mit1deltaPHD(unknown)
- mkt1delta
- mlo2::Tn-seq
- mmf2::Tn-seq
- mrc1::Tn-seq
- mrt4::Tn-seq
- msi2::Tn-seq
- ned1::Tn-seq
- nhp6::Tn-seq
- noc1::Tn-seq
- noc201::Tn-seq
- nog1::Tn-seq
- nop2::Tn-seq
- nop4::Tn-seq
- nop58::Tn-seq
- nup155::Tn-seq
- nup45::Tn-seq
- nur1delta
- nxt1::Tn-seq
- oga1::Tn-seq
- pas1::Tn-seq
- pcf1-ED*(Y340A,W348A aa)
- pcf1-KER*(R147E,K150E,K154E,R161E,K168E aa)
- pcf1-PIPmut(Q172A,L175A,F178A,F179A aa)
- pcf2::Tn-seq
- pet1::Tn-seq
- pfd1::Tn-seq
- pgi1::Tn-seq
- pha2::Tn-seq
- pli1delta
- pob3::Tn-seq
- pob3delta
- pof3delta
- pot1delta
- prp10-1(A1050V,S1058F aa)
- prp11::Tn-seq
- prp12-1(G3340A nt)
- prp16-2(Q140*)
- prp16-F528S(aa)
- prp31::Tn-seq
- prp39-1(unknown)
- prp5-1(unknown)
- prp8-1(unknown)
- prw1::Tn-seq
- prw1delta
- pss1::Tn-seq
- pub2::Tn-seq
- pub2delta
- puf1::Tn-seq
- puf6::Tn-seq
- put2::Tn-seq
- pyp2::Tn-seq
- rad25delta
- raf1-F319A(aa)
- raf1delta
- raf2delta
- rbm10delta
- rdp1::Tn-seq
- rdp1delta
- res2::Tn-seq
- ria1::Tn-seq
- rik1-304(unknown)
- rik1::Tn-seq
- rik1delta
- rkr1::Tn-seq
- rlc1::Tn-seq
- rna14::Tn-seq
- rod1::Tn-seq
- rpb1::Tn-seq
- rpb2-N44F(N44F)(aa)
- rpb2-m203(N44Y aa)
- rpb8::Tn-seq
- rpl1502::Tn-seq
- rpl1702::Tn-seq
- rpl1802::Tn-seq
- rpl1902::Tn-seq
- rpl2102::Tn-seq
- rpl2301::Tn-seq
- rpl2401::Tn-seq
- rpl2402::Tn-seq
- rpl2502::Tn-seq
- rpl2801::Tn-seq
- rpl29::Tn-seq
- rpl3602::Tn-seq
- rpl402::Tn-seq
- rpl4302::Tn-seq
- rpl502::Tn-seq
- rpl702::Tn-seq
- rpl803::Tn-seq
- rpm1::Tn-seq
- rpp21::Tn-seq
- rpt2::Tn-seq
- rpt3-1(Q384*)
- rpt6::Tn-seq
- rrp41::Tn-seq
- rrp9::Tn-seq
- rss1-deltaC(112-131 Δaa)[Knockdown]
- rss1-deltaN(1-9 Δaa)[Knockdown]
- rss1delta
- saf1delta
- saf3::Tn-seq
- saf5delta
- san1::Tn-seq
- sap49::Tn-seq
- sde2delta
- sds21::Tn-seq
- set2::Tn-seq
- set3-deltaPHD(5-49 Δaa)
- set3delta
- sfc7::Tn-seq
- sgf11::Tn-seq
- sgf73delta
- sif2::Tn-seq
- sif3::Tn-seq
- sir2::Tn-seq
- sir2delta
- skb15::Tn-seq
- slm9delta
- smd2::Tn-seq
- smd3delta
- snd302::Tn-seq
- snt2::Tn-seq
- spc25::Tn-seq
- spt16-1(unknown)[Knockdown]
- spt16::Tn-seq
- spt6-K20(708-789 Δaa)
- spt6delta
- srb8::Tn-seq
- srp2::Tn-seq
- ssr4delta
- stc1delta
- stt4::Tn-seq
- swi6-115(W269R aa)
- swi6::Tn-seq
- swi6delta
- swi7-1(G1116E aa)
- swi7-H4(unknown)
- sxa1::Tn-seq
- taf1::Tn-seq
- taf4::Tn-seq
- taf7::Tn-seq
- tas3-W265A,G266A(aa)
- tas3::Tn-seq
- tas3delta
- tea4::Tn-seq
- tfa1::Tn-seq
- tfb1::Tn-seq
- tif313::Tn-seq
- tif5::Tn-seq
- tom40::Tn-seq
- tos4::Tn-seq
- tpz1delta
- trk1::Tn-seq
- trm6::Tn-seq(gcd10::Tn-seq)
- trm732::Tn-seq
- trm7::Tn-seq
- uaf2::Tn-seq
- ubc13::Tn-seq
- ubp14::Tn-seq
- ubp3::Tn-seq
- ubp8::Tn-seq
- ura1::Tn-seq
- ura2::Tn-seq
- ura3::Tn-seq
- urh2::Tn-seq
- vma3::Tn-seq
- vms1::Tn-seq
- vps26::Tn-seq
- vps4::Tn-seq
- vtc2::Tn-seq
- wee1delta
- wtf13::Tn-seq
- ysh1::Tn-seq
- zas1::Tn-seq
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
References:
Genes:
Genotypes:
