Phenotype ontology term - FYPO:0000168 - abnormal mitotic spindle assembly checkpoint
Term summary
- ID
- FYPO:0000168
- Name
- abnormal mitotic spindle assembly checkpoint
- Ontology or CV name
- Phenotype
- Definition
- A cell cycle checkpoint phenotype in which the spindle assembly checkpoint of a mitotic cell cycle is abnormal. The mitotic spindle assembly checkpoint normally delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions.
Annotation
Multi-locus phenotype
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Genotypes:
- TetR-bub1-CD1(TetR-bub1-S381A,T383A,T386A) TetR-mps1
- TetR-bub1-TPR(TetR-bub1(1-240)) TetR-mps1
- TetR-bub1 TetR-mps1 mad1delta
- TetR-bub1 TetR-mps1 mad2delta
- TetR-bub1 TetR-mps1 mad3delta
- TetR-bub1N(TetR-bub1(aa1-325)) TetR-mps1
- alp5-1134(S402N aa) bub1delta
- alp5-1134(S402N aa) mad1delta
- alp5-1134(S402N aa) mad2delta
- alp5-1134(S402N aa) mad3delta
- apc14delta mad2+(wild type)[Overexpression] nda3-311(unknown)
- apc14delta mph1+(wild type)[Overexpression] nda3-311(unknown)
- apc15delta mad2delta nda3-311(unknown)
- apc15delta nda3-311(unknown)
- bub1-KD(K762R,D900N aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa)
- bub1-SATATA(S381A,T383A,T386A aa) mad1-KT-tethered(mad1-mis12 fusion)
- bub1-delta28-160(aa) nda3-KM311(G93E aa)
- bub3delta mad2delta
- bub3delta mph1-delta(1-302)(aa)
- bub3delta mph1delta
- bub3delta nda3-KM311(G93E aa)
- cdc11-119(unknown) cut7-446(I954T aa)
- cnp3C-mph1(cnp3C fusion)[Overexpression] spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- cut7-24(V968A aa) mad2delta
- cut7-24(V968A aa) mad3delta
- hhp2-K41R-7A(K41R,S307A,T309A,T329A,T345A,S358A,S368A,S381A aa) nda3-KM311(G93E aa)
- hta1-S121A(S122A aa) hta2-S121A(S122A aa)
- mad2delta mis6-302(G135E aa)
- mad2delta nda3-311(unknown)
- slp1+(wild type) slp1-mr63(A131P,F132T aa)
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- bub1+(wild type) bub1+(wild type) spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- bub3delta mph1-delta(1-150)(aa)
- bub3delta spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- hhp1-R261E(aa) hhp2delta nda3-KM311(G93E aa)
- hhp1-R272E,K273E(aa) hhp2delta nda3-KM311(G93E aa)
- mad2+(wild type)[Knockdown] slp1+(wild type)[Overexpression]
- mad2-S92A(aa) mad3-C9A(S246A,S251A,T259A,T262A,T265A,S276A,T278A,S279A,S289A aa)
- mad3+(wild type)[Knockdown] slp1+(wild type)[Overexpression]
- mad3-KEN1-AAA(K20A,E21A,N22A aa) slp1+(wild type)[Knockdown]
- slp1+(wild type) slp1-mr63(A131P,F132T aa)[Knockdown]
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- apc14delta ark1-as3(L166A,S229A,Q28R,Q176R aa) nda3-311(unknown)
- ark1-as3(L166A,S229A,Q28R,Q176R aa) klp5delta klp6delta nda3-KM311(G93E aa)
- ark1-as3(L166A,S229A,Q28R,Q176R aa) klp5delta nda3-KM311(G93E aa)
- ark1-as3(L166A,S229A,Q28R,Q176R aa) klp6delta nda3-KM311(G93E aa)
- dis2delta paa1+(wild type)[Overexpression]
- dis2delta par1+(wild type)[Overexpression]
- dis2delta par2+(wild type)[Overexpression]
- dis2delta ppa1+(wild type)[Overexpression]
- dis2delta ppa2+(wild type)[Overexpression]
- dis2delta ppa3+(wild type)[Overexpression]
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Genotypes:
- bub1-deltaGLEBS(264-299 Δaa) spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- bub1delta bub3delta spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- bub3delta spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- cnp3C-bub1(cnp3C fusion)[Overexpression] spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- mph1delta spc7-12E(T77E,S221E,T257E,T338E,T366E,T395E,T413E,T422E,T453E,T507E,T529E,T552E aa)
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Genotypes:
- TetR-D(1-302)Mph1(TetR-mph1delta(1-302))[Ectopic] TetR-spc7(1-666)-9TA(TetR-spc7Δ667-1364-T257A,T338A,T366A,T395A,T422A,T453A,T507A,T529A,T552A)[Ectopic] mad1-KAKA(K24A,K25A aa)
- TetR-bub1-N700delta(TetR-bub1(1-700)) TetR-mps1
- TetR-bub1 TetR-mps1
- TetR-bub1 TetR-mps1 bub3delta
- TetR-bub1 TetR-mps1 mad1-deltaCC(unknown)
- TetR-bub1 TetR-mps1 spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- alp5-1134(S402N aa) bub3delta
- dis2delta nda3-KM311(G93E aa)
- hhp2-7A(S307A,T309A,T329A,T345A,S358A,S368A,S381A aa) nda3-KM311(G93E aa)
- mad2delta mal2-1(E277K aa)
- mal2-1(E277K aa) mph1delta
- nda3-KM311(G93E aa) sds21delta
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Single locus phenotype
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- csi1delta
- dma1-I194A(aa)
- dma1-L241A,V245A(aa)
- dma1-L241A(aa)
- dma1-R64A(aa)
- dma1delta
- mad3delta
- sid4N-ppc89C(sid4(1-305)-ppc89(280-783))
- spc7-9MA(M254A,M335A,M363A,M392A,M419A,M450A,M504A,M526A,M549A aa)
- spc7-9TA(T257A,T338A,T366A,T395A,T422A,T453A,T507A,T529A,T552A aa)
- spc7-9TE(T257E,T338E,T366E,T395E,T422E,T453E,T507E,T529E,T552E aa)
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- TetR-spc7(1-666)-9TA(TetR-spc7Δ667-1364-T257A,T338A,T366A,T395A,T422A,T453A,T507A,T529A,T552A)
- alp14delta
- alp4-1891(unknown)
- atf1delta
- bub1-KD(K762R,D900N aa)
- bub1-SATATA(S381A,T383A,T386A aa)
- bub1delta
- bub3delta
- dma1delta
- mad1+(wild type)[Overexpression]
- mad1-1-526(527-676 Δaa)
- mad1-1-600(601-676 Δaa)
- mad1-4A(R510A,V511A,L512A,Q513A aa)
- mad1-564-676(1-563 Δaa)
- mad1-585-676(1-584 Δaa)
- mad1-RLK/AAA-KT-tethered(mis12-mad1-RLK-580-AAA)
- mad1-RLK/AAA(R580A,L581A,K582A aa)
- mad1-RLK/ALA(R580A,K582A aa)
- mad1-RL/AG(R510A,L512G aa)
- mad1delta
- mad2+(wild type)[Knockdown]
- mad2-R133A,Q134A(aa)
- mad2-R133A(aa)
- mad2-W74A(aa)
- mad2delta
- mad3-KEN1-AAA(K20A,E21A,N22A aa)
- mis6-302(G135E aa)
- mph1-delta(1-302)(aa)
- nda3-1828(unknown)
- ndc80-AK01(L246P aa)
- nuf2-1(unknown)
- nuf2delta
- rad21-45(I67T aa)
- sgo2delta
- sim4delta
- slp1-mr63(A131P,F132T aa)
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- apc15delta
- bub3-RA,KA(R201A,K221A aa)
- dma1-C210H,H212A(aa)
- dma1-H88A(aa)
- dma1-R64A(aa)
- dma1delta
- dma1deltaFHA(1-139 Δaa)
- dma1deltaRF(191-268 Δaa)
- mad1+(wild type)[Knockdown]
- mad1+(wild type)[Overexpression]
- mad1-306-676(1-305 Δaa)[Knockdown]
- mad1-458-676(1-457 Δaa)
- mad1-EDD/QNN(E670Q,D673N,D676N aa)
- mad1-ELK/AAA(E670A,L672A,K674A aa)
- mad1-F592A(aa)
- mad1-R593A(aa)
- mad1-deltahelix(662-676 Δaa)
- mad2+(wild type)[Knockdown]
- mad2-4A(S69A,S92A,S187A,S189A aa)
- mad2-5A(S69A,S92A,S187A,T188A,S189A aa)
- mad2-R133A,Q134A(aa)
- mad2-S187D(aa)
- mad2-S189D(aa)
- mad2-S92A(aa)
- mad2-S92D(aa)
- mad2delta
- mad3(1-281)(282-310 Δaa)
- mad3+(wild type)[Knockdown]
- mad3-18A(S19A,S31A,S33A,S38A,S40A,T44A,T64A,T93A,S94A,S246A,S251A,T259A,T262A,T265A,S276A,T278A,S279A,S289A aa)
- mad3-ABBA1mut(F242A,V244A,Y245A,D247A aa)
- mad3-ABBA2mut(F299A,V301A,H302A,D304A aa)
- mad3-C9A(S246A,S251A,T259A,T262A,T265A,S276A,T278A,S279A,S289A aa)
- mad3-Dbox-mimic(L216K aa)
- mad3-Dbox-mimic-mut(V213A,L216A aa)
- mad3-KEN2-AAA(K271A,E272A,N273A aa)
- mph1-kd(D459A aa)
- mph1delta
- slp1+(wild type)[Overexpression]
- spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- spc7-9TA(T257A,T338A,T366A,T395A,T422A,T453A,T507A,T529A,T552A aa)
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Genotypes:
- bub1-P*(T340A,T423A,T455A,S466A aa)
- bub1-deltaGLEBS(264-299 Δaa)
- bub1delta
- bub3delta
- cnp3C-bub1(cnp3C fusion)[Overexpression]
- mph1delta
- spc7-12E(T77E,S221E,T257E,T338E,T366E,T395E,T413E,T422E,T453E,T507E,T529E,T552E aa)
- spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
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