Phenotype ontology term - FYPO:0001347 - nucleic acid metabolism phenotype during vegetative growth

FYPO:0002553 - abnormal double-strand break processing

References:

• PMID:23211746
• PMID:27098497

Genes:

• ast1 (SPCC962.05)
• csn1 (SPBC215.03c)
• csn5 (SPAC1687.13c)
• ddb1 (SPAC17H9.10c)
• exo1 (SPBC29A10.05)
• htb1 (SPCC622.09)
• rad2 (SPAC3G6.06c)
• rhp6 (SPAC18B11.07c)
• rqh1 (SPAC2G11.12)
• spd1 (SPAC29B12.03)
• wdr70 (SPAC343.17c)

Genotypes:

• ast1delta exo1+(wild type)[Knockdown] rad2delta
• csn1delta spd1delta
• csn1delta spd1delta wdr70delta
• csn5delta spd1delta
• csn5delta spd1delta wdr70delta
• ddb1delta spd1delta
• exo1delta spd1delta
• exo1delta spd1delta wdr70delta
• htb1-K119R(K120R aa) spd1delta
• rhp6delta spd1delta
• rqh1delta spd1delta
• rqh1delta spd1delta wdr70delta
• spd1delta wdr70delta

FYPO:0000468 - abnormal mating type switching

References:

• PMID:35908934
• PMID:36951094

Genes:

• dcr1 (SPCC188.13c)
• pcr1 (SPAC21E11.03c)
• set1 (SPCC306.04c)
• shf1 (SPAC22F8.12c)
• swi2 (SPAC1142.03c)
• swi6 (SPAC664.01c)

Genotypes:

• dcr1delta pcr1delta
• dcr1delta set1delta
• dcr1delta shf1delta
• pcr1delta set1delta
• pcr1delta shf1delta
• set1delta shf1delta
• set1delta swi2-5A(F271A,D272A,V274A,V275A,I276A aa)
• set1delta swi2-AT12-AA(G219A,R220A,P221A,G242A,R243A,P244A aa)
• swi2-5A(F271A,D272A,V274A,V275A,I276A aa) swi6delta
• swi2-AT12-AA(G219A,R220A,P221A,G242A,R243A,P244A aa) swi6delta

FYPO:0001343 - abnormal mitotic DNA replication

References:

• PMID:9303312

Genes:

• cdc10 (SPBC336.12c)
• cdc13 (SPBC582.03)
• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)

Genotypes:

• cdc10-V50(H362Y aa) cdc13+(wild type)[Knockdown] cig1delta cig2delta

FYPO:0000481 - abnormal mitotic recombination

References:

• PMID:21098121

Genes:

• pot1 (SPAC26H5.06)
• rqh1 (SPAC2G11.12)

Genotypes:

• pot1delta rqh1-K547A(aa)

FYPO:0007409 - abnormal mRNA alternative polyadenylation

References:

• PMID:34389684

Genes:

• nc-tgp1 (SPNCRNA.1698)
• seb1 (SPAC222.09)

Genotypes:

• nc-tgp1-PAS-mutant(unknown) seb1-G476S(aa)

FYPO:0003596 - abnormal snRNA 3'-end processing

References:

• PMID:26213367

Genes:

• cid14 (SPAC12G12.13c)
• mpn1 (SPAC23C11.10)

Genotypes:

• cid14delta mpn1delta

FYPO:0000122 - abnormal telomere maintenance during vegetative growth

References:

• PMID:29774234

Genes:

• stn1 (SPBC409.12c)
• taz1 (SPAC16A10.07c)

Genotypes:

• stn1-226(I226A,L227A,L229A aa) taz1delta

FYPO:0002254 - abnormal telomere morphology during vegetative growth

References:

• PMID:18160711

Genes:

• est1 (SPBC2D10.13)
• pku70 (SPCC126.02c)
• rad3 (SPBC216.05)
• taz1 (SPAC16A10.07c)
• trt1 (SPBC29A3.14c)

Genotypes:

• est1delta taz1delta trt1-D590A(aa)
• est1delta taz1delta trt1-D743A(aa)
• est1delta taz1delta trt1delta
• pku70delta taz1delta trt1-D590A(aa)
• pku70delta taz1delta trt1-D743A(aa)
• pku70delta taz1delta trt1delta
• rad3delta taz1delta trt1delta
• taz1delta trt1delta

FYPO:0008339 - abolished 3' end uridylation of non-polyadenylated RNA

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)
• cid16 (SPAC17H9.01)

Genotypes:

• cid16delta cid1delta

FYPO:0006087 - abolished DNA resection during replication fork processing

References:

• PMID:28475874
• PMID:29215009

Genes:

• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• pku70 (SPCC126.02c)
• rad50 (SPAC1556.01c)
• rad52 (SPAC30D11.10)

Genotypes:

• ctp1delta exo1delta
• ctp1delta exo1delta pku70delta
• exo1delta pku70delta
• exo1delta rad50delta
• exo1delta rad52delta

FYPO:0003485 - abolished DNA synthesis

References:

• PMID:9303312

Genes:

• cdc10 (SPBC336.12c)
• cdc13 (SPBC582.03)
• cig1 (SPCC4E9.02)
• cig2 (SPAPB2B4.03)

Genotypes:

• cdc10-V50(H362Y aa) cdc13+(wild type)[Knockdown] cig1delta cig2delta

FYPO:0005399 - abolished double-strand break repair via homologous recombination

References:

• PMID:12628934

Genes:

• pku70 (SPCC126.02c)
• rad51 (SPAC644.14c)

Genotypes:

• pku70delta rad51delta

FYPO:0000469 - abolished mating type switching

References:

• PMID:1620099

Genes:

• swi3 (SPBC30D10.04)
• swi6 (SPAC664.01c)

Genotypes:

• swi3-1(unknown) swi6-115(W269R aa)

FYPO:0003844 - abolished mitotic chromosome condensation

References:

• PMID:21540296

Genes:

• cnd2 (SPCC306.03c)

Genotypes:

• cnd2-1(A114T aa) cnd2-3E(S5E,S41E,S52E aa)[Overexpression]

FYPO:0006728 - abolished mitotic DNA replication initiation

References:

• PMID:22718908
• PMID:7883794

Genes:

• cdc10 (SPBC336.12c)
• pol1 (SPAC3H5.06c)
• rum1 (SPBC32F12.09)
• spp2 (SPBC17D11.06)

Genotypes:

• cdc10-129(T429A aa) rum1delta
• pol1-AID[Knockdown] spp2-AID[Knockdown]

FYPO:0008336 - abolished mRNA poly(A) tail uridylation

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)
• cid16 (SPAC17H9.01)

Genotypes:

• cid16delta cid1delta

FYPO:0001768 - abolished tRNA-Asp C38 methylation

References:

• PMID:26424849

Genes:

• qtr1 (SPAC1687.19c)
• qtr2 (SPAC2F3.13c)

Genotypes:

• qtr1delta qtr2delta

FYPO:0006731 - decreased CMG complex progression from replication origin

References:

• PMID:22718908

Genes:

• cdc20 (SPBC25H2.13c)
• pol1 (SPAC3H5.06c)
• spp2 (SPBC17D11.06)

Genotypes:

• cdc20-ct1deltaN(1-1217,Y1520N,D1625G,L1726S,S1904P aa) pol1-AID[Knockdown] spp2-AID[Knockdown]
• pol1-AID[Knockdown] spp2-AID[Knockdown]

FYPO:0006318 - decreased DNA resection during replication fork processing

References:

• PMID:29215009

Genes:

• exo1 (SPBC29A10.05)
• rqh1 (SPAC2G11.12)

Genotypes:

• exo1delta rqh1delta

FYPO:0003660 - decreased double-strand break repair during vegetative growth

References:

• PMID:39387272

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)

Genotypes:

• hhp1-as(M84G aa) hhp2-as(M85G aa)

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

• PMID:12628934
• PMID:25165823
• PMID:27098497
• PMID:27325741
• PMID:38718864
• PMID:39387272

Genes:

• chk1 (SPCC1259.13)
• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• fbh1 (SPBC336.01)
• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• htb1 (SPCC622.09)
• pku70 (SPCC126.02c)
• rad51 (SPAC644.14c)
• rad55 (SPAC3C7.03c)
• rad57 (SPAC20H4.07)
• shf1 (SPAC22F8.12c)
• spd1 (SPAC29B12.03)
• ubp8 (SPAC13A11.04c)
• wdr70 (SPAC343.17c)

Genotypes:

• chk1delta ctp1-25(G187*)
• chk1delta ctp1-6(D250*)
• exo1+(wild type)[Overexpression] spd1delta wdr70delta
• exo1delta spd1delta
• exo1delta spd1delta wdr70delta
• fbh1delta rad51delta
• fbh1delta rad57delta
• hhp1-as(M84G aa) hhp2-as(M85G aa)
• htb1-G52D(G53D aa) shf1delta ubp8delta
• htb1-G52D(G53D aa) ubp8delta
• htb1-P102L(P103L aa) shf1delta ubp8delta
• htb1-P102L(P103L aa) ubp8delta
• pku70delta rad55delta
• rad51delta rad55delta
• spd1delta wdr70delta

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

• PMID:28292918
• PMID:39387272

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• lig4 (SPCC1183.05c)
• mre11 (SPAC13C5.07)

Genotypes:

• hhp1-as(M84G aa) hhp2-as(M85G aa)
• lig4delta mre11delta

FYPO:0006921 - decreased gene conversion at mitotic DNA replication fork barriers

References:

• PMID:31149897

Genes:

• elg1 (SPBC947.11c)
• rad51 (SPAC644.14c)
• srs2 (SPAC4H3.05)

Genotypes:

• elg1delta rad51delta
• elg1delta srs2delta

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

• PMID:17724078
• PMID:19798055
• PMID:27697832
• PMID:34292936

Genes:

• cdc27 (SPBC1734.02c)
• exo1 (SPBC29A10.05)
• lig4 (SPCC1183.05c)
• mus81 (SPCC4G3.05c)
• pcn1 (SPBC16D10.09)
• pku70 (SPCC126.02c)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rad55 (SPAC3C7.03c)
• rqh1 (SPAC2G11.12)

Genotypes:

• cdc27-D1(160-372 Δaa) rad51delta
• exo1delta rad55delta
• exo1delta rqh1delta
• lig4delta rad55delta
• mus81delta rad51delta
• pcn1-K107R(aa) rad51delta
• pku70delta rad55delta
• rad51delta rad52-R45K(aa)

FYPO:0003081 - decreased genetic imprinting at mating-type locus

References:

• PMID:23260662

Genes:

• clr4 (SPBC428.08c)
• lsd1 (SPBC146.09c)
• lsd2 (SPAC23E2.02)
• set1 (SPCC306.04c)
• set6 (SPBP8B7.07c)
• set9 (SPCC4B3.12)

Genotypes:

• clr4delta lsd1-E918(E918*)
• lsd1-E918(E918*) set1delta
• lsd1-E918(E918*) set6delta
• lsd1-E918(E918*) set9delta
• lsd1-ao(K603A,K604A aa) lsd2-ao(K823A,K824A aa)

FYPO:0000470 - decreased mating type switching

References:

• PMID:15537537
• PMID:18388861
• PMID:22042869
• PMID:30759238

Genes:

• cdc23 (SPBC1347.10)
• mus81 (SPCC4G3.05c)
• swi1 (SPBC216.06c)
• swi10 (SPBC4F6.15c)
• swi2 (SPAC1142.03c)
• swi3 (SPBC30D10.04)
• swi5 (SPBC409.03)
• swi6 (SPAC664.01c)

Genotypes:

• cdc23-M36(D232G,V265I aa) swi1-1(disruption)
• cdc23-M36(D232G,V265I aa) swi1-111(unknown)
• cdc23-M36(D232G,V265I aa) swi3-1(unknown)
• cdc23-M36(D232G,V265I aa) swi3-146(unknown)
• cdc23-M36(D232G,V265I aa) swi3-157(unknown)
• mus81delta swi10delta
• swi2delta swi5delta
• swi2delta swi6-(unknown)

FYPO:0003286 - decreased mitotic chromosome condensation

References:

• PMID:21633354
• PMID:26869222

Genes:

• cdc25 (SPAC24H6.05)
• cut3 (SPBC146.03c)
• sfc3 (SPBC336.07)

Genotypes:

• cdc25-22(C532Y aa)[Knockdown] cut3-477(S1147P aa)[Knockdown]
• cut3-477(S1147P aa) sfc3-1(unknown)

FYPO:0005424 - decreased mitotic chromosome condensation during telophase

References:

• PMID:21540296

Genes:

• cut14 (SPBP4H10.06c)
• nda3 (SPBC26H8.07c)

Genotypes:

• cut14-208(S861P aa) nda3-KM311(G93E aa)

FYPO:0008332 - decreased mRNA poly(A) tail uridylation

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)
• lsm1 (SPBC3D6.08c)

Genotypes:

• cid1delta lsm1delta

FYPO:0003175 - decreased nucleotide-excision repair during cellular response to UV

References:

• PMID:10652237

Genes:

• rhp23 (SPBC2D10.12)
• uve1 (SPBC19C7.09c)

Genotypes:

• rhp23delta uve1delta

FYPO:0003923 - decreased rate of mitotic DNA replication elongation

References:

• PMID:34108240

Genes:

• cdc45 (SPAC17D4.02)
• cds1 (SPCC18B5.11c)

Genotypes:

• cdc45-3A(S275A,S322A,S397A aa) cds1delta
• cdc45-3D(S275D,S322D,S397D aa) cds1delta

FYPO:0007532 - decreased replication fork colocalization with nuclear pore complex

References:

• PMID:33159083

Genes:

• exo1 (SPBC29A10.05)
• nup131 (SPBP35G2.06c)
• nup132 (SPAC1805.04)
• pli1 (SPAC1687.05)
• rad50 (SPAC1556.01c)
• rfp1 (SPAC19A8.10)
• rfp2 (SPAC343.18)

Genotypes:

• exo1delta rad50delta
• nup131delta nup132delta
• nup132delta pli1delta
• rfp1delta rfp2delta

FYPO:0007255 - decreased replication fork processing

References:

• PMID:34108240

Genes:

• cdc45 (SPAC17D4.02)
• cds1 (SPCC18B5.11c)

Genotypes:

• cdc45-3A(S275A,S322A,S397A aa) cds1delta
• cdc45-3D(S275D,S322D,S397D aa) cds1delta

FYPO:0003589 - decreased replication slippage during replication fork processing

References:

• PMID:29215009
• PMID:33159083
• PMID:38917328

Genes:

• alm1 (SPAC1486.04c)
• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• nup131 (SPBP35G2.06c)
• nup132 (SPAC1805.04)
• nup60 (SPCC285.13c)
• pku70 (SPCC126.02c)
• pmt3 (SPBC365.06)
• rad50 (SPAC1556.01c)
• rpn10 (SPAC637.10c)

Genotypes:

• alm1delta nup60delta
• alm1delta pmt3-KallR(K14R,K30R,K39R,K51R,K53R,K54R,K60R,K63R,K71R aa)
• ctp1delta exo1delta
• ctp1delta exo1delta pku70delta
• ctp1delta rad50delta
• exo1delta pku70delta
• nup131delta nup132delta
• nup132delta rpn10delta
• nup60delta rpn10delta
• pmt3-KallR(K14R,K30R,K39R,K51R,K53R,K54R,K60R,K63R,K71R aa) rpn10delta

FYPO:0004009 - decreased rRNA transcription

References:

• PMID:2839305
• PMID:40132111

Genes:

• cbp1 (SPBC1105.04c)
• clr4 (SPBC428.08c)
• top1 (SPBC1703.14c)
• top2 (SPBC1A4.03c)

Genotypes:

• cbp1delta clr4delta
• top1-701(unknown) top2-191(unknown)

FYPO:0005357 - decreased site-specific DNA replication termination at RTS1 barrier

References:

• PMID:19416828

Genes:

• eso1 (SPBC16A3.11)
• kpa1 (SPCC553.07c)
• pmt3 (SPBC365.06)
• rev3 (SPAC688.10)
• rqh1 (SPAC2G11.12)
• rtf2 (SPAC1D4.09c)
• srs2 (SPAC4H3.05)

Genotypes:

• eso1delta kpa1delta rev3delta rtf2delta
• eso1delta rtf2delta
• kpa1delta rtf2delta
• pmt3delta rtf2delta
• rev3delta rtf2delta
• rqh1delta rtf2delta
• rtf2delta srs2delta

FYPO:0006073 - decreased small RNA degradation

References:

• PMID:28541282

Genes:

• cid12 (SPCC663.12)
• cid14 (SPAC12G12.13c)

Genotypes:

• cid12delta cid14delta

FYPO:0005786 - decreased spatial extent of double-strand break processing

References:

• PMID:21931565
• PMID:27729451

Genes:

• cdc24 (SPAC8F11.07c)
• exo1 (SPBC29A10.05)
• rqh1 (SPAC2G11.12)

Genotypes:

• cdc24-ts(C114R aa) exo1delta
• cdc24-ts(C114R aa) rqh1delta
• exo1delta rqh1delta

FYPO:0006544 - decreased transcription during mitosis

References:

• PMID:9755169

Genes:

• cdc10 (SPBC336.12c)
• cdc13 (SPBC582.03)
• res1 (SPBC725.16)

Genotypes:

• cdc10-129(T429A aa) cdc13delta90(1-90 Δaa)[Overexpression]
• cdc13delta90(1-90 Δaa)[Overexpression] res1delta

FYPO:0003251 - decreased transcription from SRE promoter

References:

• PMID:32053662

Genes:

• gsk3 (SPAC1687.15)
• gsk31 (SPBC8D2.01)
• ssp2 (SPCC74.03c)

Genotypes:

• gsk31delta gsk3delta
• gsk31delta gsk3delta ssp2delta
• gsk31delta ssp2delta

FYPO:0006251 - decreased tRNA aminoacylation

References:

• PMID:28977649

Genes:

• sla1 (SPAC57A10.10c)
• trm1 (SPBC25D12.05)

Genotypes:

• sla1delta trm1delta

FYPO:0004031 - decreased UV-damage excision repair

References:

• PMID:9092661

Genes:

• rad13 (SPBC3E7.08c)
• rad2 (SPAC3G6.06c)
• uve1 (SPBC19C7.09c)

Genotypes:

• rad13::ura4+(disruption) rad2::ura4+(disruption) uvde::LEU2+(disruption)
• rad13::ura4+(disruption) uvde::LEU2+(disruption)

FYPO:0000778 - delayed onset of double-strand break repair

References:

• PMID:8026462

Genes:

• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)

Genotypes:

• hhp1::ura4+(nt544)(disruption)[Null] hhp2::m-TN3-LEU2(disruption)[Null]

FYPO:0004003 - delayed onset of replication fork processing

References:

• PMID:33159083

Genes:

• nup131 (SPBP35G2.06c)
• nup132 (SPAC1805.04)
• pli1 (SPAC1687.05)

Genotypes:

• nup131delta nup132delta
• nup132delta pli1delta

FYPO:0002019 - elongated telomeres during vegetative growth

References:

• PMID:11676925
• PMID:12196391
• PMID:12589755
• PMID:12676088
• PMID:17429064
• PMID:18160711
• PMID:18615848
• PMID:19546237
• PMID:19620282
• PMID:22354040
• PMID:24925530
• PMID:25131669
• PMID:25245948
• PMID:26063574
• PMID:26365187
• PMID:29216371
• PMID:29422501
• PMID:29422503
• PMID:29774234
• PMID:30796050
• PMID:31131414
• PMID:34255844
• PMID:41201383

Genes:

• cay1 (SPBC2F12.12c)
• ccq1 (SPCC188.07)
• cdc2 (SPBC11B10.09)
• cds1 (SPCC18B5.11c)
• chk1 (SPCC1259.13)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• clr6 (SPBC36.05c)
• crb2 (SPBC342.05)
• est1 (SPBC2D10.13)
• hip1 (SPBC31F10.13c)
• hus1 (SPAC20G4.04c)
• mit1 (SPBP35G2.10)
• mre11 (SPAC13C5.07)
• nse2 (SPAC16A10.06c)
• pku70 (SPCC126.02c)
• pli1 (SPAC1687.05)
• pmt3 (SPBC365.06)
• pof8 (SPAC17G6.17)
• pol1 (SPAC3H5.06c)
• pot1 (SPAC26H5.06)
• poz1 (SPAC19G12.13c)
• rad1 (SPAC1952.07)
• rad17 (SPAC14C4.13)
• rad26 (SPAC9E9.08)
• rad3 (SPBC216.05)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rad9 (SPAC664.07c)
• rap1 (SPBC1778.02)
• rif1 (SPAC6F6.17)
• rqh1 (SPAC2G11.12)
• set1 (SPCC306.04c)
• spp1 (SPAC6B12.10c)
• spp2 (SPBC17D11.06)
• ssb1 (SPBC660.13c)
• ssu72 (SPAC3G9.04)
• stn1 (SPBC409.12c)
• taz1 (SPAC16A10.07c)
• tel1 (SPCC23B6.03c)
• tls1 (SPAC1D4.01)
• tor1 (SPBC30D10.10c)
• tpz1 (SPAC6F6.16c)
• trt1 (SPBC29A3.14c)

Genotypes:

• cay1delta tls1delta
• ccq1(1-441)-13xMyc-est1 ccq1delta
• ccq1(1-441)(442-735 Δaa) ccq1-13xMyc-est1
• ccq1(1-441)(442-735 Δaa) ccq1-13xMyc-est1 pmt3delta
• ccq1(1-441)(442-735 Δaa) pmt3delta
• ccq1(1-441)(442-735 Δaa) tpz1-K242R(aa)
• ccq1(139-735)(1-138 Δaa) ccq1-13xMyc-est1
• ccq1(500-735)(1-499 Δaa) ccq1-13xMyc-est1
• ccq1-13xMyc-est1 ccq1delta
• ccq1-13xMyc-est1 ccq1delta clr3delta
• ccq1-13xMyc-est1 ccq1delta clr4delta
• ccq1-13xMyc-est1 ccq1delta rad51delta
• ccq1-13xMyc-est1 ccq1delta rap1delta
• ccq1-13xMyc-est1 ccq1delta rif1delta
• ccq1-13xMyc-est1 ccq1delta tpz1-K242R(aa)
• ccq1-13xMyc-est1 clr3delta
• ccq1-13xMyc-est1 clr4delta
• ccq1-13xMyc-est1 mit1delta
• ccq1-13xMyc-est1 pmt3delta
• ccq1-13xMyc-est1 rap1delta
• ccq1-13xMyc-est1 rif1delta
• ccq1-13xMyc-est1 tpz1-K242R(aa)
• ccq1-13xMyc-est1 trt1delta
• ccq1-T93A-13xMyc-est1 ccq1delta
• ccq1-T93A(aa) trt1-PK-tpz1(trt1-9xPK-tpz1)
• cdc2-M68(unknown) ssu72delta
• cds1+(wild type)[Overexpression] pol1+(wild type)[Overexpression] swi7-H4(unknown)
• cds1delta chk1delta taz1delta
• cds1delta set1::Kan(disruption)[Null]
• cds1delta taz1delta
• cds1delta tor1delta
• chk1delta set1::Kan(disruption)[Null]
• chk1delta ssu72delta
• chk1delta taz1delta
• chk1delta tor1delta
• clr6-1(G269D aa) hip1delta
• crb2delta taz1delta
• hus1delta set1::Kan(disruption)[Null]
• hus1delta taz1delta
• mre11delta taz1delta
• nse2-SA(C195S,H197A aa) tpz1-K242R(aa)
• pku70delta taz1delta
• pku70delta tpz1-K242R(aa)
• pli1delta tpz1-K242R(aa)
• pmt3delta tpz1-K242R(aa)
• pof8delta rap1delta
• pof8delta rif1delta
• pof8delta taz1delta
• pol1+(wild type)[Overexpression] ssu72delta
• pol1-ts13(470-472 Δaa) ssu72delta
• pot1+(wild type)[Overexpression] rad11-D223Y(aa) taz1delta
• poz1-GBP-E104Q(poz1-GBP-E104Q fusion) rap1deltaPID-GFP(rap1delta(460-505)-GFP tag)
• poz1-R196E(aa) tpz1-I501R(aa)
• poz1-R218E-GBP-E104Q(poz1-R218E-GBP-E104Q fusion) rap1-GFP(rap1-GFP tag)
• poz1-R218E-GBP-R36K,E45K(poz1-R218E-GBP-R36K,E45K fusion) rap1-GFP(rap1-GFP tag)
• poz1-R218E-GBP-R36K(poz1-R218E-GBP-R36K fusion) rap1-GFP(rap1-GFP tag)
• poz1-R218E(aa) rap1-GFP(rap1-GFP tag)
• poz1-cDNA(106-144,347-440 Δnt) rap1-cDNA(96-141,514-596 Δnt) tls1delta
• poz1-cDNA(106-144,347-440 Δnt) tls1delta
• poz1-taz1 rap1delta taz1delta
• poz1deltaNTD-GBP-wt(poz1delta(2-28)-GBP) tpz1-GFP(tpz1-GFP tag)
• poz1delta rad11-D223Y(aa)
• poz1delta rad3-D2249E(aa)
• poz1delta rap1delta taz1delta tpz1-taz1[Knockdown]
• poz1delta tls1delta
• poz1delta tpz1+(wild type)[Overexpression]
• poz1delta tpz1-K242R(aa)
• poz1delta tpz1-K75A(aa)
• rad11-D223Y(aa) rad3-D2249E(aa)
• rad11-D223Y(aa) rap1delta
• rad11-D223Y(aa) rqh1-K547A(aa) taz1delta
• rad11-D223Y(aa) rqh1-K547R(aa) taz1delta
• rad11-D223Y(aa) rqh1delta taz1delta
• rad11-D223Y(aa) stn1-226(I226A,L227A,L229A aa)
• rad17delta set1::Kan(disruption)[Null]
• rad17delta taz1delta
• rad1delta set1::Kan(disruption)[Null]
• rad1delta taz1delta
• rad26delta taz1delta
• rad3delta taz1delta
• rad51delta ssu72delta
• rad52delta rap1-7A(S317A,S329A,S484A,S487A,S496A,S497A,S538A aa)
• rad52delta tpz1-K242R(aa)
• rad9delta set1::Kan(disruption)[Null]
• rad9delta taz1delta
• rap1-cDNA(96-141,514-596 Δnt) tls1delta
• rap1-taz1 rap1delta taz1-Myb(1-551 Δaa)
• rap1delta rif1delta
• rap1delta stn1-226(I226A,L227A,L229A aa)
• rap1delta tls1delta
• rap1delta tpz1-K242R(aa)
• rap1delta tpz1-K75A(aa)
• rif1-PP1(V41A,F43A,I65A,L66A aa) stn1-226(I226A,L227A,L229A aa)
• rif1delta ssu72-C13S(aa)
• rif1delta ssu72delta
• rif1delta stn1-226(I226A,L227A,L229A aa)
• rif1delta tpz1-K242R(aa)
• rqh1delta taz1delta
• set1::Kan(disruption)[Null] tel1delta
• spp1-9(unknown) ssu72delta
• spp2-9(unknown) ssu72delta
• ssu72delta stn1+(wild type)[Overexpression]
• ssu72delta stn1-75(L198S aa)
• taz1delta tel1delta
• taz1delta tls1delta
• taz1delta tpz1-K242R(aa)
• taz1delta tpz1-K75A(aa)
• taz1delta trt1delta
• tel1delta tor1delta
• tel1delta tpz1-K242R(aa)

FYPO:0004985 - entangled telomeres during vegetative growth

References:

• PMID:21098121
• PMID:22313747

Genes:

• pot1 (SPAC26H5.06)
• rqh1 (SPAC2G11.12)
• trt1 (SPBC29A3.14c)

Genotypes:

• pot1delta rqh1-K547A(aa)
• rqh1-K547A(aa) trt1delta

FYPO:0005432 - globally decreased mitotic recombination

References:

• PMID:31584934

Genes:

• hht2 (SPBC8D2.04)
• rqh1 (SPAC2G11.12)

Genotypes:

• hht2-H113D(H114D aa)[Knockdown] rqh1delta

FYPO:0008338 - increased 3' end uridylation of non-polyadenylated RNA

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)
• dis32 (SPAC2C4.07c)
• lsm1 (SPBC3D6.08c)
• ski2 (SPCC550.03c)

Genotypes:

• cid1delta dis32delta lsm1delta
• cid1delta lsm1delta
• cid1delta lsm1delta ski2delta

FYPO:0002913 - increased antisense RNA transcription

References:

• PMID:31837996
• PMID:32496538

Genes:

• brl2 (SPCC970.10c)
• cdk9 (SPBC32H8.10)
• hrp3 (SPAC3G6.01)
• htb1 (SPCC622.09)
• pob3 (SPBC609.05)
• set2 (SPAC29B12.02c)
• spt5 (SPAC23C4.19)

Genotypes:

• brl2delta cdk9-T120G(aa)
• cdk9-T120G(aa) hrp3delta
• cdk9-T120G(aa) htb1-K119R(K120R aa)
• cdk9-T120G(aa) htb1-K119R(K120R aa) spt5-CTD-T1A(7)(801-990,S800SGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGS)
• cdk9-T120G(aa) set2delta
• cdk9-T120G(aa) spt5-CTD-T1A(7)(801-990,S800SGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGSGSKAPAWNSGS)
• hrp3delta htb1-K119R(K120R aa)
• htb1-K119R(K120R aa) pob3delta

FYPO:0000167 - increased DNA recombination at mitotic DNA replication fork barriers

References:

• PMID:31149897

Genes:

• elg1 (SPBC947.11c)
• fbh1 (SPBC336.01)

Genotypes:

• elg1delta fbh1delta

FYPO:0004251 - increased DNA resection during replication fork processing

References:

• PMID:29697047

Genes:

• crb2 (SPBC342.05)
• exo1 (SPBC29A10.05)
• rev7 (SPBC12D12.09)
• rqh1 (SPAC2G11.12)

Genotypes:

• crb2delta exo1delta
• crb2delta rqh1delta
• exo1delta rev7delta

FYPO:0003584 - increased double-strand break repair via nonhomologous end joining

References:

• PMID:15226425
• PMID:19798055
• PMID:25533340
• PMID:27098497

Genes:

• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• hta1 (SPCC622.08c)
• hta2 (SPAC19G12.06c)
• rqh1 (SPAC2G11.12)
• spd1 (SPAC29B12.03)
• wdr70 (SPAC343.17c)
• xlf1 (SPCC24B10.14c)

Genotypes:

• ctp1delta xlf1.AA(T180A,S192A aa)
• exo1delta rqh1delta
• hta1-S129A(aa) hta2-S128A(aa)
• spd1delta wdr70delta

FYPO:0000473 - increased mitotic recombination

References:

• PMID:17515930
• PMID:28922417

Genes:

• brc1 (SPBC582.05c)
• pnk1 (SPAC23C11.04c)
• rad9 (SPAC664.07c)
• srs2 (SPAC4H3.05)

Genotypes:

• brc1delta pnk1delta
• rad9-T225C(aa) srs2delta

FYPO:0005868 - increased mitotic recombination at rDNA

References:

• PMID:19158664

Genes:

• rad52 (SPAC30D11.10)
• smc6 (SPCC5E4.06)
• swi6 (SPAC664.01c)

Genotypes:

• rad52delta smc6-74(A151T aa)
• rad52delta smc6-X(R706C aa)
• smc6-74(A151T aa) swi6delta
• smc6-X(R706C aa) swi6delta

FYPO:0006280 - increased mitotic recombination with crossover formation at centromere

References:

• PMID:28977643

Genes:

• fml1 (SPAC9.05)
• mhf1 (SPBC2D10.16)

Genotypes:

• fml1delta mhf1delta

FYPO:0004599 - increased rate of DNA replication during vegetative growth

References:

• PMID:11532929

Genes:

• cdc18 (SPBC14C8.07c)
• cdt1 (SPBC428.18)

Genotypes:

• cdc18+(wild type)[Overexpression] cdt1+(wild type)[Overexpression]

FYPO:0007814 - increased rate of mitotic DNA replication elongation during cellular response to hydroxyurea

References:

• PMID:34108240

Genes:

• cdc45 (SPAC17D4.02)
• cds1 (SPCC18B5.11c)

Genotypes:

• cdc45-3A(S275A,S322A,S397A aa) cds1delta
• cdc45-3D(S275D,S322D,S397D aa) cds1delta

FYPO:0010016 - increased replication fork stalling during cellular response to DNA damage

References:

• PMID:31262821

Genes:

• clr6 (SPBC36.05c)
• htb1 (SPCC622.09)

Genotypes:

• clr6-1(G269D aa) htb1-K33R(K34R aa)

FYPO:0005031 - increased ribonucleotide incorporation on lagging strand

References:

• PMID:25664722

Genes:

• cdc6 (SPBC336.04)
• rnh201 (SPAC4G9.02)

Genotypes:

• cdc6-L591G(aa) rnh201delta

FYPO:0005030 - increased ribonucleotide incorporation on leading strand

References:

• PMID:22144917
• PMID:25664722

Genes:

• cdc20 (SPBC25H2.13c)
• rnh201 (SPAC4G9.02)

Genotypes:

• cdc20-M630F(aa) rnh201delta

FYPO:0005402 - increased telomeric 3' overhang length during vegetative growth

References:

• PMID:12861005
• PMID:15485922

Genes:

• exo1 (SPBC29A10.05)
• mre11 (SPAC13C5.07)
• pku70 (SPCC126.02c)
• rad2 (SPAC3G6.06c)
• rad50 (SPAC1556.01c)
• taz1 (SPAC16A10.07c)
• trt1 (SPBC29A3.14c)

Genotypes:

• exo1delta mre11delta pku70delta taz1delta
• exo1delta pku70delta rad50delta taz1delta
• exo1delta taz1delta
• mre11-D25A(aa) taz1delta
• mre11delta pku70delta taz1delta
• pku70delta rad50delta taz1delta
• rad2delta taz1delta
• taz1delta trt1delta

FYPO:0002908 - increased transcription at telomere during vegetative growth

References:

• PMID:31980821

Genes:

• bqt4 (SPBC19C7.10)
• ter1 (SPNCRNA.214)

Genotypes:

• bqt4delta ter1delta

FYPO:0002895 - increased transcription during cellular response to calcium ion

References:

• PMID:22496451

Genes:

• ppb1 (SPBP4H10.04)
• prz1 (SPAC4G8.13c)

Genotypes:

• ppb1delta prz1+(wild type)[Overexpression]

FYPO:0001854 - increased transcription during cellular response to iron

References:

• PMID:20200159

Genes:

• lkh1 (SPAC1D4.11c)
• tup11 (SPAC18B11.10)
• tup12 (SPAC630.14c)

Genotypes:

• lkh1delta tup11delta tup12delta
• tup11delta tup12delta

FYPO:0000780 - increased transcription during vegetative growth

References:

• PMID:12221110
• PMID:20200159

Genes:

• lkh1 (SPAC1D4.11c)
• tup11 (SPAC18B11.10)
• tup12 (SPAC630.14c)

Genotypes:

• lkh1delta tup11delta tup12delta
• tup11delta tup12delta

FYPO:0000239 - increased transcription from MCB promoter

References:

• PMID:11781565

Genes:

• cig2 (SPAPB2B4.03)
• res1 (SPBC725.16)

Genotypes:

• Pcig2-96--12-LacZ(cig2-96---12-LacZ fusion) res1+(wild type)[Overexpression]
• Pcig2-lacZ(cig2 2kb 5'UTR-LacZ fusion) res1+(wild type)[Overexpression]
• Pcig2-mut1((-64)-(-44)-LacZ fusion) res1+(wild type)[Overexpression]

FYPO:0007615 - increased transcription from STREP promoter during cellular response to nitric oxide

References:

• PMID:33400299

Genes:

• fmd2 (SPBC1198.01)
• yhb1 (SPAC869.02c)

Genotypes:

• fmd2delta yhb1delta

FYPO:0003587 - loss of gross chromosomal rearrangement during replication fork processing

References:

• PMID:25313826

Genes:

• pcf1 (SPBC29A10.03c)
• rqh1 (SPAC2G11.12)

Genotypes:

• pcf1delta rqh1delta

FYPO:0003468 - normal RNA splicing

References:

• PMID:34706246

Genes:

• prp2 (SPBC146.07)
• snu1 (SPSNRNA.01)
• ypt7 (SPBC405.04c)

Genotypes:

• prp2-C387Y(aa) snu1-triple(C7A,T8G,G9T nt)
• prp2-C387Y(aa) ypt7-5'SS+BPmut(A476C,T477A,G483A,T532C nt)

FYPO:0002905 - normal telomere maintenance

References:

• PMID:29851556

Genes:

• mre11 (SPAC13C5.07)
• nbs1 (SPBC6B1.09c)
• rad3 (SPBC216.05)
• tel1 (SPCC23B6.03c)

Genotypes:

• mre11-TBD(Nbs1(554-613)-Mre11-C) nbs1delta rad3delta
• nbs1delta rad3delta tel1+(wild type)[Overexpression]

FYPO:0006279 - normal termination of RNA polymerase II transcription

References:

• PMID:27401558

Genes:

• dbl8 (SPBC29A10.10c)
• sen1 (SPAC6G9.10c)

Genotypes:

• dbl8delta sen1delta

FYPO:0006742 - normal transcription from MCB promoter

References:

• PMID:31260531
• PMID:35157728

Genes:

• bdf2 (SPAC631.02)
• gcn5 (SPAC1952.05)
• nrm1 (SPBC16A3.07c)
• rep2 (SPBC2F12.11c)
• tor1 (SPBC30D10.10c)
• ubp8 (SPAC13A11.04c)

Genotypes:

• bdf2delta tor1delta
• gcn5delta tor1delta
• nrm1delta rep2delta
• tor1delta ubp8delta

FYPO:0003498 - premature mitotic DNA replication initiation

References:

• PMID:7883794

Genes:

• rum1 (SPBC32F12.09)
• wee1 (SPCC18B5.03)

Genotypes:

• rum1delta wee1-50(G850E aa)

FYPO:0006272 - premature mitotic DNA replication initiation from late origin

References:

• PMID:31289327

Genes:

• rif1 (SPAC6F6.17)
• trt1 (SPBC29A3.14c)

Genotypes:

• rif1delta trt1delta

FYPO:0003107 - progressively shortening telomeres during vegetative growth

References:

• PMID:12589755
• PMID:22313747
• PMID:24925530
• PMID:25398909
• PMID:27253066
• PMID:29422501
• PMID:29422503
• PMID:30796050
• PMID:33378677

Genes:

• cay1 (SPBC2F12.12c)
• ccq1 (SPCC188.07)
• pof8 (SPAC17G6.17)
• poz1 (SPAC19G12.13c)
• rad3 (SPBC216.05)
• rqh1 (SPAC2G11.12)
• set1 (SPCC306.04c)
• ssu72 (SPAC3G9.04)
• stn1 (SPBC409.12c)
• tel1 (SPCC23B6.03c)
• ter1 (SPNCRNA.214)
• tpz1 (SPAC6F6.16c)
• trt1 (SPBC29A3.14c)

Genotypes:

• cay1delta trt1delta
• ccq1-T93A(aa) ssu72delta
• pof8delta ter1+(wild type)[Overexpression]
• pof8delta ter1delta
• pof8delta trt1delta::his3+(disruption)[Null]
• poz1delta tpz1-R81E(aa)
• rad3delta set1::Kan(disruption)[Null] tel1delta
• rad3delta ssu72delta
• rqh1delta trt1delta
• ssu72delta trt1delta
• stn1-S74D(aa) trt1delta
• tpz1-K242R(aa) trt1delta
• tpz1-R81E(aa) trt1delta

FYPO:0002239 - shortened telomeres during vegetative growth

References:

• PMID:11029034
• PMID:12196391
• PMID:12589755
• PMID:14654689
• PMID:15485922
• PMID:18157149
• PMID:19546237
• PMID:20140190
• PMID:22313747
• PMID:22354040
• PMID:25245948
• PMID:29160296
• PMID:29216371
• PMID:29422503
• PMID:35277511
• PMID:9771717

Genes:

• bmc1 (SPBC2A9.10)
• ccq1 (SPCC188.07)
• cds1 (SPCC18B5.11c)
• chk1 (SPCC1259.13)
• crb2 (SPBC342.05)
• dna2 (SPBC16D10.04c)
• est1 (SPBC2D10.13)
• exo1 (SPBC29A10.05)
• hus1 (SPAC20G4.04c)
• mre11 (SPAC13C5.07)
• nbs1 (SPBC6B1.09c)
• pku70 (SPCC126.02c)
• pof8 (SPAC17G6.17)
• poz1 (SPAC19G12.13c)
• rad1 (SPAC1952.07)
• rad17 (SPAC14C4.13)
• rad26 (SPAC9E9.08)
• rad3 (SPBC216.05)
• rad50 (SPAC1556.01c)
• rad9 (SPAC664.07c)
• rqh1 (SPAC2G11.12)
• set1 (SPCC306.04c)
• ssb1 (SPBC660.13c)
• tel1 (SPCC23B6.03c)
• ter1 (SPNCRNA.214)
• tls1 (SPAC1D4.01)
• tor1 (SPBC30D10.10c)
• tpz1 (SPAC6F6.16c)
• trt1 (SPBC29A3.14c)

Genotypes:

• bmc1+(wild type)[Overexpression] pof8delta
• ccq1(131-735)(1-130 Δaa) ccq1-13xMyc-est1
• ccq1delta poz1-A36R(aa)
• ccq1delta poz1-R218E(aa)
• ccq1delta poz1delta
• ccq1delta tpz1-I501R(aa)
• cds1delta chk1delta pku70delta
• cds1delta pku70delta
• chk1delta pku70delta
• crb2delta pku70delta
• dna2-C2(L1079S aa) exo1delta
• dna2-C2(L1079S aa) rad3delta
• dna2-C2(L1079S aa) rad50delta
• hus1delta mre11delta
• hus1delta pku70delta
• hus1delta pku70delta tel1delta
• hus1delta rad1delta
• hus1delta rad26delta
• hus1delta rad3delta
• hus1delta rad9delta
• hus1delta tel1delta
• mre11delta pku70delta
• mre11delta rad17delta
• mre11delta rad1delta
• mre11delta rad9delta
• nbs1-c60-delta(554-613 Δaa) rad26delta rad3+(wild type)[Overexpression]
• nbs1-c60-delta(554-613 Δaa) rad26delta tel1+(wild type)[Overexpression]
• nbs1-c60-delta(554-613 Δaa) rad3(1-1476)(1477-2386 Δaa)
• nbs1-c60-delta(554-613 Δaa) rad3(1-1476)(1477-2386 Δaa) tel1+(wild type)[Overexpression]
• nbs1-c60-delta(554-613 Δaa) rad3delta tel1+(wild type)[Overexpression]
• nbs1delta rad26delta rad3+(wild type)[Overexpression]
• pku70delta rad11-D223Y(aa)
• pku70delta rad17delta
• pku70delta rad17delta tel1delta
• pku70delta rad1delta
• pku70delta rad1delta tel1delta
• pku70delta rad26delta
• pku70delta rad3delta
• pku70delta rad9delta
• pku70delta rad9delta tel1delta
• pku70delta tel1delta
• pku70delta trt1+(wild type)[Overexpression]
• pof8delta ter1+(wild type)[Overexpression]
• rad11-D223Y(aa) rad3delta
• rad11-D223Y(aa) rad50delta
• rad17delta rad3delta
• rad17delta tel1delta
• rad17delta tor1delta
• rad1delta rad3delta
• rad1delta tel1delta
• rad26delta rad3+(wild type)[Overexpression]
• rad3(1-1476)(1477-2386 Δaa) tel1+(wild type)[Overexpression]
• rad3-136(unknown) tel1delta
• rad3delta rad9delta
• rad3delta set1::Kan(disruption)[Null]
• rad3delta tel1+(wild type)[Overexpression]
• rad3delta tor1delta
• rad9delta tel1delta
• rqh1-K547A(aa) trt1delta
• ter1+(wild type) ter1-C234T(nt)[Overexpression]
• ter1+(wild type) ter1-T230G,A232T(nt)[Overexpression]
• tls1delta trt1delta

FYPO:0003106 - stable shortened telomeres during vegetative growth

References:

• PMID:26063574
• PMID:26305931
• PMID:26365187
• PMID:29422501
• PMID:29422503

Genes:

• ccq1 (SPCC188.07)
• pof8 (SPAC17G6.17)
• pot1 (SPAC26H5.06)
• poz1 (SPAC19G12.13c)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rap1 (SPBC1778.02)
• rif1 (SPAC6F6.17)
• ter1 (SPNCRNA.214)
• tpz1 (SPAC6F6.16c)
• trt1 (SPBC29A3.14c)

Genotypes:

• ccq1-F157A,K174E(aa) tpz1-L449A(aa)
• ccq1-F157A,K174E(aa) trt1delta
• pof8delta poz1delta
• pof8delta rad51delta
• pof8delta rad52delta
• pof8delta rap1delta
• pof8delta rif1::ura4+(ura4+ @ 5' HindIII site)
• pot1-tpz1 pot1delta tpz1delta
• rad51delta ter1-STEloop(TTTT1065AAAA nt)[Overexpression]

FYPO:0005403 - telomeric 3' overhang absent during vegetative growth

References:

• PMID:12861005
• PMID:15485922

Genes:

• dna2 (SPBC16D10.04c)
• mre11 (SPAC13C5.07)
• pku70 (SPCC126.02c)
• rad2 (SPAC3G6.06c)
• rad50 (SPAC1556.01c)
• taz1 (SPAC16A10.07c)

Genotypes:

• dna2-C2(L1079S aa) pku70delta taz1delta
• dna2-C2(L1079S aa) rad2+(wild type)[Overexpression] taz1delta
• dna2-C2(L1079S aa) taz1delta
• mre11delta taz1delta
• rad50delta taz1delta

FYPO:0006298 - abnormal 5.8S rRNA 3'-end processing

References:

• PMID:18438419

Genes:

• eri1 (SPBC30B4.08)

Genotypes:

• eri1delta

FYPO:0003686 - abnormal box C/D snoRNA 3'-end processing

References:

• PMID:20609363

Genes:

• snu32 (SPSNRNA.07)

Genotypes:

• snu32-+41(GTG295ACA nt)
• snu32-+46(AA300TT nt)
• snu32-+50(TGT303ACA nt)
• snu32-+56(AA309TT nt)

FYPO:0000188 - abnormal DNA repair during vegetative growth

References:

• PMID:11554922

Genes:

• bir1 (SPCC962.02c)

Genotypes:

• cut17-275(A990T aa)

FYPO:0002553 - abnormal double-strand break processing

References:

• PMID:10779336
• PMID:23628481
• PMID:25203555
• PMID:33723569

Genes:

• dbl1 (SPCC2H8.05c)
• eso1 (SPBC16A3.11)
• exo1 (SPBC29A10.05)
• mst1 (SPAC637.12c)

Genotypes:

• dbl1+(wild type)[Overexpression]
• eso1-G799D(aa)
• exo1delta
• mst1-L344S(aa)

FYPO:0000777 - abnormal double-strand break repair during vegetative growth

References:

• PMID:1480481
• PMID:19158664
• PMID:25203555
• PMID:7885834

Genes:

• mre11 (SPAC13C5.07)
• pxd1 (SPCC1322.02)
• rad16 (SPCC970.01)
• rad21 (SPCC338.17c)
• smc6 (SPCC5E4.06)
• swi10 (SPBC4F6.15c)

Genotypes:

• pxd1delta
• pxd1delta108-226(aa)
• rad16delta
• rad21-45(I67T aa)
• rad32-1(D135N aa)
• smc6-74(A151T aa)
• smc6-X(R706C aa)
• swi10delta

FYPO:0003661 - abnormal double-strand break repair via nonhomologous end joining

References:

• PMID:10373582
• PMID:17038309
• PMID:24847916

Genes:

• lig4 (SPCC1183.05c)
• mre11 (SPAC13C5.07)
• xlf1 (SPCC24B10.14c)
• xrc4 (SPAC6G9.16c)

Genotypes:

• lig4delta
• mre11delta
• xlf1delta
• xrc4delta

FYPO:0000468 - abnormal mating type switching

References:

• PMID:11780129
• PMID:16127433
• PMID:16157682
• PMID:27648579
• PMID:35908934
• PMID:36951094
• PMID:8423854

Genes:

• brl1 (SPCC1919.15)
• brl2 (SPCC970.10c)
• cul4 (SPAC3A11.08)
• hht3 (SPBC1105.11c)
• pol1 (SPAC3H5.06c)
• psc3 (SPAC17H9.20)
• rad21 (SPCC338.17c)
• raf1 (SPCC613.12c)
• raf2 (SPCC970.07c)
• rhp6 (SPAC18B11.07c)
• set1 (SPCC306.04c)
• shf1 (SPAC22F8.12c)
• swi2 (SPAC1142.03c)
• swi6 (SPAC664.01c)

Genotypes:

• brl1delta
• brl2delta
• cul4-1(marker gene insertion at 3'-UTR)
• hht3-K9M(K10M aa)
• psc3-1T(unknown)
• psc3-2T(unknown)
• psc3-4T(unknown)
• rad21-K1(unknown)
• raf1delta
• raf2delta
• rhp6delta
• set1-Y897A(aa)
• set1delta
• shf1delta
• swi2-5A(F271A,D272A,V274A,V275A,I276A aa)
• swi2-AT1-A(G219A,R220A,P221A aa)
• swi2-AT12-AA(G219A,R220A,P221A,G242A,R243A,P244A aa)
• swi2-AT2-A(G242A,R243A,P244A aa)
• swi6delta
• swi7-1(G1116E aa)

FYPO:0003659 - abnormal mating type switching resulting in duplication or deletion in mating-type region

References:

• PMID:15197176
• PMID:1620099
• PMID:29852001
• PMID:8290356

Genes:

• ckb1 (SPAC1851.03)
• clr1 (SPBC2D10.17)
• clr2 (SPAC1B3.17)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• msh2 (SPBC19G7.01c)
• msh3 (SPAC8F11.03)
• pof3 (SPCC338.16)
• pxd1 (SPCC1322.02)
• rad16 (SPCC970.01)
• rad52 (SPAC30D11.10)
• rad57 (SPAC20H4.07)
• raf1 (SPCC613.12c)
• rik1 (SPCC11E10.08)
• sir2 (SPBC16D10.07c)
• swd2 (SPBC18H10.06c)
• swi6 (SPAC664.01c)

Genotypes:

• ckb1delta
• clr1delta
• clr2delta
• clr3delta
• clr4delta
• msh2delta
• msh3delta
• pof3delta
• pxd1delta
• rad16delta
• rad22-67(unknown)
• rad57delta
• raf1delta
• rik1delta
• sir2delta
• swd2delta
• swi6-115(W269R aa)
• swi6delta

FYPO:0001343 - abnormal mitotic DNA replication

References:

• PMID:10101168
• PMID:10588638
• PMID:10880469
• PMID:11027263
• PMID:11937031
• PMID:1361173
• PMID:18414064
• PMID:19109429
• PMID:21725325
• PMID:28481910
• PMID:29774234
• PMID:7865880
• PMID:7916658
• PMID:8298187
• PMID:8618924
• PMID:8631307
• PMID:8838655
• PMID:8895665
• PMID:9356477
• PMID:9563836
• PMID:9619628
• PMID:9891039

Genes:

• cdc18 (SPBC14C8.07c)
• cdc20 (SPBC25H2.13c)
• cdc24 (SPAC8F11.07c)
• cdc45 (SPAC17D4.02)
• dna2 (SPBC16D10.04c)
• drc1 (SPAC6B12.11)
• hsk1 (SPBC776.12c)
• mcm2 (SPBC4.04c)
• mcm4 (SPCC16A11.17)
• mcm5 (SPAC1B2.05)
• mcm6 (SPBC211.04c)
• orc1 (SPBC29A10.15)
• orc5 (SPBC646.14c)
• pcn1 (SPBC16D10.09)
• psf1 (SPBP23A10.09)
• rfc3 (SPAC27E2.10c)
• stn1 (SPBC409.12c)

Genotypes:

• cdc18-DEAD(DE286AA aa)
• cdc18-K205A(aa)
• cdc18-K46(unknown)
• cdc20-P7(unknown)
• cdc20-P7(unknown)
• cdc24-M38(R370*)
• dna2-C2(L1079S aa)
• drc1-1(unknown)
• drc1-2(unknown)
• hsk1-1312(S314I aa)
• mcm4delta
• mis5-268(unknown)
• nda1-KM376(unknown)
• nda4-107(unknown)
• nda4-108(R50C aa)
• orc1delta
• orc5-H19(V43A,C71R,Y177C,P191S,I352T aa)
• orp1-4(unknown)
• pcn1-3(H44A aa)
• pcn1-K164R(aa)
• pcn1::ura4+[Null]
• psf1-HBD
• rfc3-1(R216W aa)
• sna41-912(unknown)
• stn1-226(I226A,L227A,L229A aa)

FYPO:0001344 - abnormal mitotic DNA replication initiation

References:

• PMID:20799962
• PMID:26436827

Genes:

• mcm4 (SPCC16A11.17)
• rif1 (SPAC6F6.17)

Genotypes:

• rid2-1(G1541A nt)
• rif1delta

FYPO:0004844 - abnormal mitotic DNA replication lagging strand elongation

References:

• PMID:28481910

Genes:

• pcn1 (SPBC16D10.09)

Genotypes:

• pcn1-K164R(aa)

FYPO:0004845 - abnormal mitotic DNA replication lagging strand elongation at telomere

References:

• PMID:26041456

Genes:

• ssb1 (SPBC660.13c)

Genotypes:

• rad11-D223Y(aa)

FYPO:0000481 - abnormal mitotic recombination

References:

• PMID:9649516

Genes:

• cdc24 (SPAC8F11.07c)

Genotypes:

• cdc24-G1(G1301A nt)

FYPO:0007409 - abnormal mRNA alternative polyadenylation

References:

• PMID:32499400
• PMID:34389684

Genes:

• nc-tgp1 (SPNCRNA.1698)
• rpb1 (SPBC28F2.12)
• seb1 (SPAC222.09)

Genotypes:

• nc-tgp1-5seb1-bs(T543A,G549C,A554T,A560AT,T561A,C570G,G573A,C579G,T582A nt)[Knockdown]
• rpb1-N494D(aa)
• seb1-G476S(aa)

FYPO:0008155 - abnormal regulatory lncRNA 3'-end processing

References:

• PMID:32415063

Genes:

• cbc1 (SPAC6G10.07)
• mmi1 (SPCC736.12c)
• red1 (SPAC1006.03c)
• rrp6 (SPAC1F3.01)

Genotypes:

• cbc1-1(unknown)
• mmi1delta
• red1delta
• rrp6delta

FYPO:0003088 - abnormal replication fork arrest

References:

• PMID:21118960
• PMID:24806966

Genes:

• exo1 (SPBC29A10.05)
• rad17 (SPAC14C4.13)
• rad50 (SPAC1556.01c)
• rad9 (SPAC664.07c)
• reb1 (SPBC1198.11c)

Genotypes:

• exo1delta
• rad17delta
• rad50delta
• rad9delta
• reb1delta

FYPO:0003586 - abnormal replication fork processing

References:

• PMID:31575705

Genes:

• fft3 (SPAC25A8.01c)

Genotypes:

• fft3delta

FYPO:0005909 - abnormal RNA 3'-end processing during cellular response to endoplasmic reticulum stress

References:

• PMID:23066505

Genes:

• bip1 (SPAC22A12.15c)
• ire1 (SPAC167.01)

Genotypes:

• bip1-G2365C(nt)
• bip1-G2365T(nt)
• bip1-deltaTTAACTGGTG\C(2356-2366 Δnt)
• ire1delta

FYPO:0004492 - abnormal RNA 5'-end processing

References:

• PMID:17446861

Genes:

• hst4 (SPAC1783.04c)

Genotypes:

• hst4delta

FYPO:0003596 - abnormal snRNA 3'-end processing

References:

• PMID:23022480
• PMID:26213367

Genes:

• mpn1 (SPAC23C11.10)

Genotypes:

• mpn1-MUT(H109A,H199A aa)[Overexpression]
• mpn1delta

FYPO:0006464 - abnormal telomere length during vegetative growth

References:

• PMID:26088418

Genes:

• taz1 (SPAC16A10.07c)

Genotypes:

• taz1-4A(D258A,E259A,E260A,D261A aa)
• taz1-4R(D258R,E259R,E260R,D261R aa)
• taz1-L431R(aa)
• taz1-L445R(aa)
• taz1delta

FYPO:0000122 - abnormal telomere maintenance during vegetative growth

References:

• PMID:11029034
• PMID:17977837
• PMID:29774234

Genes:

• pku70 (SPCC126.02c)
• stn1 (SPBC409.12c)
• tbf1 (SPBC19G7.13)

Genotypes:

• pku70delta
• stn1-226(I226A,L227A,L229A aa)
• tbf1+(wild type)[Overexpression]

FYPO:0002254 - abnormal telomere morphology during vegetative growth

References:

• PMID:18615848

Genes:

• pku80 (SPBC543.03c)
• rad50 (SPAC1556.01c)
• rad51 (SPAC644.14c)

Genotypes:

• pku80delta
• rad50delta
• rad51delta

FYPO:0005981 - abnormal termination of RNA polymerase I transcription

References:

• PMID:27035982

Genes:

• reb1 (SPBC1198.11c)

Genotypes:

• reb1-W460R,L485P(aa)

FYPO:0004811 - abnormal termination of RNA polymerase II transcription

References:

• PMID:12504018
• PMID:24493644
• PMID:25240800
• PMID:28765164
• PMID:30076928

Genes:

• dhp1 (SPAC26A3.12c)
• dis3 (SPBC26H8.10)
• hrp1 (SPAC1783.05)
• mmi1 (SPCC736.12c)
• pfs2 (SPAC12G12.14c)
• rna14 (SPAC6F12.17)
• rrp41 (SPAC3G9.10c)
• rrp6 (SPAC1F3.01)

Genotypes:

• dhp1-54(unknown)
• dis3+(wild type)[Knockdown]
• dis3-exo-(D516N aa)
• hrp1delta
• mmi1delta
• pfs2-11(unknown)
• rna14-A394E(aa)
• rrp41+(wild type)[Knockdown]
• rrp41-co(S62SGESEGESEGLE)
• rrp6delta

FYPO:0004814 - abnormal termination of RNA polymerase II transcription at highly transcribed protein-coding genes

References:

• PMID:25417108

Genes:

• dcr1 (SPCC188.13c)

Genotypes:

• dcr1delta

FYPO:0004812 - abnormal termination of RNA polymerase II transcription at rDNA

References:

• PMID:25417108

Genes:

• dcr1 (SPCC188.13c)

Genotypes:

• dcr1delta

FYPO:0004813 - abnormal termination of RNA polymerase II transcription at tDNA

References:

• PMID:25417108

Genes:

• dcr1 (SPCC188.13c)

Genotypes:

• dcr1delta

FYPO:0006983 - abnormal termination of RNA polymerase III transcription

References:

• PMID:21450810
• PMID:31294478

Genes:

• rpc11 (SPAC22A12.05)
• rpc2 (SPAC4G9.08c)
• rpc37 (SPCC330.13)
• sen1 (SPAC6G9.10c)

Genotypes:

• rpc11-F32S(aa)
• rpc2-T466I(aa)
• rpc37-V189D(aa)
• sen1delta

FYPO:0003556 - abnormal transcription termination

References:

• PMID:20152800
• PMID:20609363
• PMID:24945319
• PMID:24957674

Genes:

• dhp1 (SPAC26A3.12c)
• pac1 (SPBC119.11c)
• pht1 (SPBC11B10.10c)
• snu2 (SPSNRNA.02)
• snu32 (SPSNRNA.07)
• swd22 (SPAC824.04)
• xap5 (SPCC1020.12c)

Genotypes:

• dhp1delta867-991(aa)
• pac1-ts(unknown)
• pht1delta
• snu2delta195-234(nt)
• snu32-+41(GTG295ACA nt)
• snu32-+46(AA300TT nt)
• snu32-+50(TGT303ACA nt)
• snu32-+56(AA309TT nt)
• swd22delta
• xap5delta

FYPO:0001766 - abnormal tRNA methylation

References:

• PMID:30646830

Genes:

• trm401 (SPAC17D4.04)
• trm402 (SPAC23C4.17)

Genotypes:

• trm401delta
• trm402delta

FYPO:0008450 - abnormal tRNA modification at postion A37

References:

• PMID:40829803

Genes:

• tit1 (SPAC343.15)

Genotypes:

• tit1delta

FYPO:0008451 - abnormal tRNA modification at postion A58

References:

• PMID:40829803

Genes:

• trm6 (SPBC800.08)

Genotypes:

• trm6delta

FYPO:0008449 - abnormal tRNA modification at postion U34

References:

• PMID:40829803

Genes:

• elp6 (SPBC3H7.10)

Genotypes:

• elp6delta

FYPO:0001554 - abnormal tRNA processing

References:

• PMID:25401760

Genes:

• rmp1 (SPAC323.08)

Genotypes:

• rmp1-KA18(Q12R,P57L,Y60H,V86A,L132S,I142T,Y149C,L161P,S167P,V192A,F210L aa)

FYPO:0005016 - abolished 18S rRNA acetylation

References:

• PMID:25402480

Genes:

• nat10 (SPAC20G8.09c)

Genotypes:

• nat10-447(G285D aa)

FYPO:0001173 - abolished 7-methylguanosine cap hypermethylation

References:

• PMID:17284461

Genes:

• tgs1 (SPAC2G11.15c)

Genotypes:

• tgs1delta

FYPO:0000181 - abolished crossover

References:

• PMID:17304215

Genes:

• rad51 (SPAC644.14c)
• rad57 (SPAC20H4.07)

Genotypes:

• rad51delta
• rad57delta

FYPO:0002041 - abolished deadenylation-independent decapping of nuclear-transcribed mRNA

References:

• PMID:23319050
• PMID:28031482

Genes:

• pdc1 (SPAC20G4.08)
• pdc2 (SPBC19G7.10c)

Genotypes:

• pdc1delta
• pdc2delta

FYPO:0006087 - abolished DNA resection during replication fork processing

References:

• PMID:28475874
• PMID:29215009

Genes:

• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)

Genotypes:

• ctp1delta
• exo1delta

FYPO:0003485 - abolished DNA synthesis

References:

• PMID:6943408

Genes:

• cdc20 (SPBC25H2.13c)
• cdc22 (SPAC1F7.05)
• cdc27 (SPBC1734.02c)
• cdc28 (SPBC19C2.01)

Genotypes:

• cdc20-M10(unknown)
• cdc20-M31(unknown)
• cdc20-P7(unknown)
• cdc22-M45(unknown)
• cdc27-K3(G57R aa)
• cdc27-M57(unknown)
• cdc27-P11(G57E aa)
• cdc28-P8(unknown)

FYPO:0005436 - abolished double-strand break repair

References:

• PMID:17178839

Genes:

• cut8 (SPAC17C9.13c)

Genotypes:

• cut8delta

FYPO:0005399 - abolished double-strand break repair via homologous recombination

References:

• PMID:17936710

Genes:

• rad51 (SPAC644.14c)

Genotypes:

• rad51delta

FYPO:0005459 - abolished double-strand break repair via nonhomologous end joining

References:

• PMID:17936710
• PMID:23188080

Genes:

• lig4 (SPCC1183.05c)
• pku70 (SPCC126.02c)
• pku80 (SPBC543.03c)

Genotypes:

• lig4delta
• pku70delta
• pku80delta

FYPO:0003080 - abolished genetic imprinting at mating-type locus

References:

• PMID:23260662
• PMID:26201080

Genes:

• lsd1 (SPBC146.09c)
• swi1 (SPBC216.06c)
• swi3 (SPBC30D10.04)

Genotypes:

• lsd1delta
• swi1-111(unknown)
• swi3-146(unknown)

FYPO:0000469 - abolished mating type switching

References:

• PMID:10716938
• PMID:23260662

Genes:

• lsd1 (SPBC146.09c)
• msh3 (SPAC8F11.03)
• pol1 (SPAC3H5.06c)
• swi1 (SPBC216.06c)
• swi10 (SPBC4F6.15c)
• swi2 (SPAC1142.03c)
• swi5 (SPBC409.03)
• swi6 (SPAC664.01c)

Genotypes:

• lsd1-E918(E918*)
• swi1-(unknown)
• swi10delta
• swi2-S73(unknown)
• swi4-1(unknown)
• swi5-S39(unknown)
• swi6-115(W269R aa)
• swi7-1(G1116E aa)

FYPO:0003844 - abolished mitotic chromosome condensation

References:

• PMID:10571085
• PMID:22645654
• PMID:9740803

Genes:

• bir1 (SPCC962.02c)
• cut14 (SPBP4H10.06c)
• cut15 (SPCC962.03c)

Genotypes:

• bir1delta
• cut14-Y1(L543S aa)
• cut15-122(C395R aa)[Knockdown]
• cut15-85(G419S,G450S aa)[Knockdown]

FYPO:0006727 - abolished mitotic DNA replication elongation

References:

• PMID:22718908

Genes:

• cdc20 (SPBC25H2.13c)

Genotypes:

• cdc20-ct1(Y1520N,D1625G,L1726S,S1904P aa)

FYPO:0006728 - abolished mitotic DNA replication initiation

References:

• PMID:22718908

Genes:

• cdc20 (SPBC25H2.13c)
• sld3 (SPAC24H6.06)

Genotypes:

• cdc20-AID[Knockdown]
• sld3-10(E338G aa)

FYPO:0010026 - abolished mitotic recombination at centromere

References:

• PMID:41330900

Genes:

• rad52 (SPAC30D11.10)

Genotypes:

• rad52-Schain(Rad52 fused with 4xSUMO (active Pmt3-GG) in C-terminus)[Knockdown]

FYPO:0005356 - abolished site-specific DNA replication termination at RTS1 barrier

References:

• PMID:12840005

Genes:

• swi1 (SPBC216.06c)
• swi3 (SPBC30D10.04)

Genotypes:

• swi1-111(unknown)
• swi3-146(unknown)

FYPO:0003597 - abolished snRNA 3'-end processing

References:

• PMID:10445882

Genes:

• snu2 (SPSNRNA.02)

Genotypes:

• snu2-M1(CTTCTTCT189TACTAGTG nt)
• snu2-M2(GTTGACAG197TACTAGTA nt)
• snu2-M3(ATTTGTGA205GACTAGTC nt)

FYPO:0001853 - abolished transcription during iron starvation

References:

• PMID:8321236

Genes:

• frp1 (SPBC1683.09c)

Genotypes:

• frp1(-19--138)((-138)-(-19))
• frp1(-43--138)((-138)-(-43))

FYPO:0001443 - abolished transcription during vegetative growth

References:

• PMID:19056896
• PMID:7909513

Genes:

• res2 (SPAC22F3.09c)
• rst2 (SPAC6F12.02)

Genotypes:

• res2delta
• rst2delta

FYPO:0005497 - abolished transcription from CRE promoter

References:

• PMID:26108447

Genes:

• atf1 (SPBC29B5.01)

Genotypes:

• atf1delta

FYPO:0005500 - abolished transcription from CRE promoter during cellular response to miconazole

References:

• PMID:26108447

Genes:

• atf1 (SPBC29B5.01)

Genotypes:

• atf1delta

FYPO:0003796 - abolished transcription from RNA polymerase II promoter

References:

• PMID:10982411
• PMID:16874521

Genes:

• rst2 (SPAC6F12.02)
• thi1 (SPAC1486.10)
• thi5 (SPBP8B7.30c)

Genotypes:

• rst2delta
• thi1delta
• thi5delta

FYPO:0008345 - abolished tRNA cytidine N4-acetylation

References:

• PMID:38295128

Genes:

• tan1 (SPBC25H2.10c)

Genotypes:

• tan1delta

FYPO:0007021 - abolished tRNA cytosine 2'-O-methylation

References:

• PMID:25404562

Genes:

• trm7 (SPAC4F10.03c)
• trm732 (SPCC1494.07)
• trm734 (SPBC1306.02)

Genotypes:

• trm7+(wild type)[Knockdown]
• trm732delta
• trm732delta/trm732delta
• trm734delta

FYPO:0007022 - abolished tRNA guanosine 2'-O-methylation

References:

• PMID:25404562

Genes:

• trm7 (SPAC4F10.03c)
• trm734 (SPBC1306.02)

Genotypes:

• trm7+(wild type)[Knockdown]
• trm734delta/trm734delta

FYPO:0007609 - abolished tRNA guanosine 7-methylation

References:

• PMID:32841241

Genes:

• trm8 (SPCPB16A4.04c)

Genotypes:

• trm8delta

FYPO:0003957 - abolished tRNA guanosine N2,N2-dimethylation

References:

• PMID:10611485
• PMID:37805140

Genes:

• trm1 (SPBC25D12.05)

Genotypes:

• trm1-D201A(aa)
• trm1delta

FYPO:0003655 - abolished tRNA splicing

References:

• PMID:11955632

Genes:

• ptp4 (SPBC3D6.05)

Genotypes:

• ptp4-(unknown)

FYPO:0003218 - abolished tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis

References:

• PMID:22768388
• PMID:23874237
• PMID:41316862

Genes:

• ctu1 (SPBC2G5.03)
• ctu2 (SPBC19C2.13c)
• elp3 (SPAC29A4.20)

Genotypes:

• ctu1delta
• ctu2delta
• elp3-CC(C106A,C109A aa)
• elp3delta

FYPO:0005177 - abolished tRNA wobble position uridine thiolation

References:

• PMID:18391219
• PMID:22768388

Genes:

• ctu1 (SPBC2G5.03)
• elp3 (SPAC29A4.20)

Genotypes:

• ctu1-C142A,C145A(aa)
• ctu1-K62A,D63A(aa)
• ctu1-ts21(unknown)
• ctu1delta
• elp3delta

FYPO:0001768 - abolished tRNA-Asp C38 methylation

References:

• PMID:23074192
• PMID:26424849

Genes:

• pmt1 (SPBC19C2.02)
• qtr1 (SPAC1687.19c)

Genotypes:

• pmt1-C81A(aa)
• qtr1delta

FYPO:0003622 - abolished U6 2'-O-snRNA methylation at residue A41

References:

• PMID:11842100
• PMID:37403782

Genes:

• snoZ30 (SPSNORNA.25)

Genotypes:

• snoZ30delta

FYPO:0008109 - abolished U6 2'-O-snRNA methylation at residue A64

References:

• PMID:37403782

Genes:

• sno530 (SPNCRNA.530)

Genotypes:

• sno530delta

FYPO:0003928 - altered double-strand break repair junction in presence of persistent double-strand breaks

References:

• PMID:22093869
• PMID:24847916

Genes:

• lig4 (SPCC1183.05c)
• pku70 (SPCC126.02c)
• pol4 (SPAC2F7.06c)
• xlf1 (SPCC24B10.14c)
• xrc4 (SPAC6G9.16c)

Genotypes:

• lig4delta
• pku70delta
• pol4delta
• xlf1delta
• xrc4delta

FYPO:0008337 - decreased 3' end uridylation of non-polyadenylated RNA

References:

• PMID:39333464

Genes:

• cid16 (SPAC17H9.01)

Genotypes:

• cid16delta

FYPO:0007883 - decreased cleavage-dependent termination of RNA polymerase II transcription

References:

• PMID:34352089

Genes:

• dhp1 (SPAC26A3.12c)
• pac1 (SPBC119.11c)

Genotypes:

• dhp1+(wild type)[Knockdown]
• pac1-AA(pac1-FRB-GFP)

FYPO:0006731 - decreased CMG complex progression from replication origin

References:

• PMID:22718908

Genes:

• cdc20 (SPBC25H2.13c)

Genotypes:

• cdc20-ct1(Y1520N,D1625G,L1726S,S1904P aa)

FYPO:0002039 - decreased deadenylation-independent decapping of nuclear-transcribed mRNA

References:

• PMID:23319050

Genes:

• edc3 (SPBC18E5.11c)

Genotypes:

• edc3delta

FYPO:0002174 - decreased degradation of DSR-containing RNA

References:

• PMID:21317872
• PMID:23658229

Genes:

• npp106 (SPCC1739.14)
• rae1 (SPBC16A3.05c)
• red1 (SPAC1006.03c)
• red5 (SPBC337.12)

Genotypes:

• npp106delta
• rae1delta
• red1delta
• red5-2(I234Y aa)

FYPO:0003352 - decreased DNA double-strand break formation at mating-type locus

References:

• PMID:18723894
• PMID:19117951
• PMID:19416828
• PMID:29852001
• PMID:30759238
• PMID:6587363

Genes:

• brl2 (SPCC970.10c)
• cbp1 (SPBC1105.04c)
• cdc23 (SPBC1347.10)
• ckb1 (SPAC1851.03)
• clr1 (SPBC2D10.17)
• clr2 (SPAC1B3.17)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• cut4 (SPBC106.09)
• cut9 (SPAC6F12.15c)
• elp6 (SPBC3H7.10)
• msh2 (SPBC19G7.01c)
• msh3 (SPAC8F11.03)
• pof3 (SPCC338.16)
• pol1 (SPAC3H5.06c)
• pxd1 (SPCC1322.02)
• rad16 (SPCC970.01)
• rad57 (SPAC20H4.07)
• raf1 (SPCC613.12c)
• rik1 (SPCC11E10.08)
• rtf1 (SPAC22F8.07c)
• rtf2 (SPAC1D4.09c)
• sir2 (SPBC16D10.07c)
• spf1 (SPCC594.05c)
• swd1 (SPAC23H3.05c)
• swd2 (SPBC18H10.06c)
• swi1 (SPBC216.06c)
• swi2 (SPAC1142.03c)
• swi3 (SPBC30D10.04)
• swi6 (SPAC664.01c)

Genotypes:

• brl2delta
• cbp1delta
• cdc23-1E2(C239Y aa)
• cdc23-M30(T560C nt)
• cdc23-M36(D232G,V265I aa)
• ckb1delta
• clr1delta
• clr2delta
• clr3delta
• clr4delta
• cut4-553(unknown)
• cut9-665(A535T aa)
• elp6delta
• msh2delta
• msh3delta
• pof3delta
• pxd1delta
• rad16delta
• rad57delta
• raf1delta
• rik1delta
• rtf1-W405G(aa)
• rtf2-1(Q146*)
• sir2delta
• spf1delta
• swd1delta
• swd2delta
• swi1-(unknown)
• swi2delta
• swi3-(unknown)
• swi3delta
• swi6delta
• swi7-1(G1116E aa)

FYPO:0006920 - decreased DNA recombination at mitotic DNA replication fork barriers

References:

• PMID:28586299
• PMID:30667359
• PMID:31149897
• PMID:31584934

Genes:

• asf1 (SPCC663.05c)
• elg1 (SPBC947.11c)
• exo1 (SPBC29A10.05)
• fml1 (SPAC9.05)
• hht2 (SPBC8D2.04)
• mus81 (SPCC4G3.05c)
• pcf1 (SPBC29A10.03c)
• pcf2 (SPAC26H5.03)
• pcf3 (SPAC25H1.06)
• pfh1 (SPBC887.14c)

Genotypes:

• asf1-33(A16T,L61P,E119K,L121P,N156S,E180G aa)
• elg1delta
• exo1delta
• fml1delta
• hht2-H113D(H114D aa)[Knockdown]
• mus81delta
• pcf1delta
• pcf2delta
• pcf3delta
• pfh1-mt*((pfh1-M21A,M170L,M265A,M320A)-NES)[Knockdown]

FYPO:0007005 - decreased DNA recombination downstream of mitotic DNA replication fork barriers

References:

• PMID:30667359
• PMID:31149897

Genes:

• elg1 (SPBC947.11c)
• pcf2 (SPAC26H5.03)
• pcf3 (SPAC25H1.06)
• pfh1 (SPBC887.14c)

Genotypes:

• elg1delta
• pcf2delta
• pcf3delta
• pfh1-m21(M21A aa)[Knockdown]
• pfh1-mt*((pfh1-M21A,M170L,M265A,M320A)-NES)[Knockdown]

FYPO:0002340 - decreased DNA recombination during vegetative growth

References:

• PMID:23703609
• PMID:38718864

Genes:

• gad8 (SPCC24B10.07)
• htb1 (SPCC622.09)
• ste20 (SPBC12C2.02c)
• tor1 (SPBC30D10.10c)

Genotypes:

• gad8delta
• htb1-G52D(G53D aa)
• htb1-P102L(P103L aa)
• ste20delta
• tor1delta

FYPO:0006318 - decreased DNA resection during replication fork processing

References:

• PMID:29215009
• PMID:29697047
• PMID:31575705

Genes:

• exo1 (SPBC29A10.05)
• fft3 (SPAC25A8.01c)

Genotypes:

• exo1delta
• fft3-K418R(aa)
• fft3delta

FYPO:0005159 - decreased DNA synthesis involved in mitotic DNA replication

References:

• PMID:16849602
• PMID:38718864

Genes:

• cdc45 (SPAC17D4.02)
• htb1 (SPCC622.09)
• orc1 (SPBC29A10.15)

Genotypes:

• htb1-G52D(G53D aa)
• htb1-P102L(P103L aa)
• orp1-4(unknown)
• sna41-928(unknown)

FYPO:0003660 - decreased double-strand break repair during vegetative growth

References:

• PMID:10373582
• PMID:11029034
• PMID:17307401
• PMID:25580577

Genes:

• ctp1 (SPCC338.08)
• lig4 (SPCC1183.05c)
• mre11 (SPAC13C5.07)
• mus7 (SPAC6B12.02c)
• mus81 (SPCC4G3.05c)
• pku70 (SPCC126.02c)

Genotypes:

• ctp1-H274A(aa)
• ctp1-R32A,K41A(aa)
• ctp1delta
• lig4delta
• mre11delta
• mus7delta
• mus81delta
• pku70delta

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

• PMID:12628934
• PMID:17936710
• PMID:25165823
• PMID:25533340
• PMID:27098497
• PMID:27325741
• PMID:38718864
• PMID:39387272
• PMID:39789818

Genes:

• ctp1 (SPCC338.08)
• dsk1 (SPBC530.14c)
• fbh1 (SPBC336.01)
• hhp1 (SPBC3H7.15)
• hhp2 (SPAC23C4.12)
• htb1 (SPCC622.09)
• lig4 (SPCC1183.05c)
• mre11 (SPAC13C5.07)
• rad16 (SPCC970.01)
• rad3 (SPBC216.05)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rad55 (SPAC3C7.03c)
• rqh1 (SPAC2G11.12)
• shf1 (SPAC22F8.12c)
• srs2 (SPAC4H3.05)
• ubp8 (SPAC13A11.04c)
• wdr70 (SPAC343.17c)
• xlf1 (SPCC24B10.14c)

Genotypes:

• ctp1-25(G187*)
• ctp1-6(D250*)
• ctp1delta
• dsk1delta
• fbh1delta
• hhp1-K40R(aa)
• hhp2-K41R(aa)
• htb1-G52D(G53D aa)
• htb1-P102L(P103L aa)
• lig4delta
• mre11delta
• rad16delta
• rad3delta
• rad51delta
• rad52delta
• rad55delta
• rqh1delta
• shf1delta
• srs2delta
• ubp8delta
• wdr70delta
• xlf1.AA(T180A,S192A aa)
• xlf1delta

FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

References:

• PMID:11226171
• PMID:15226425
• PMID:18062930
• PMID:19798055
• PMID:23188080
• PMID:25533340
• PMID:28292918
• PMID:39387272

Genes:

• arp8 (SPAC664.02c)
• ctp1 (SPCC338.08)
• hhp1 (SPBC3H7.15)
• lig4 (SPCC1183.05c)
• mre11 (SPAC13C5.07)
• nbs1 (SPBC6B1.09c)
• pku70 (SPCC126.02c)
• rad50 (SPAC1556.01c)
• xlf1 (SPCC24B10.14c)

Genotypes:

• arp8-4A(S60A,S62A,S75A,S87A aa)
• arp8::ura4+(disruption)
• ctp1delta
• hhp1delta
• lig4delta
• mre11-H134S(aa)
• mre11-H68S(aa)
• mre11-L154D(aa)
• mre11-L77K,L154D(aa)
• mre11-L77K(aa)
• mre11delta
• nbs1delta
• pku70delta
• rad50delta
• xlf1.EE(T180E,S192E)(aa)
• xlf1delta

FYPO:0005370 - decreased fidelity of double-strand break repair via nonhomologous end joining

References:

• PMID:11226171

Genes:

• lig4 (SPCC1183.05c)
• pku70 (SPCC126.02c)

Genotypes:

• lig4delta
• pku70delta

FYPO:0006921 - decreased gene conversion at mitotic DNA replication fork barriers

References:

• PMID:28586299
• PMID:31149897
• PMID:31483748

Genes:

• mto1 (SPCC417.07c)
• rad51 (SPAC644.14c)

Genotypes:

• mto1delta
• rad51delta

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

• PMID:10908327
• PMID:15210864
• PMID:15331764
• PMID:16043696
• PMID:17304215
• PMID:17307401
• PMID:17724078
• PMID:1874411
• PMID:19798055
• PMID:23703609
• PMID:24943839
• PMID:27697832
• PMID:27729451
• PMID:31483748
• PMID:32355220
• PMID:33723569

Genes:

• cdc24 (SPAC8F11.07c)
• cdc27 (SPBC1734.02c)
• dmc1 (SPAC8E11.03c)
• dna2 (SPBC16D10.04c)
• exo1 (SPBC29A10.05)
• gad8 (SPCC24B10.07)
• kms1 (SPAC3A11.05c)
• lig4 (SPCC1183.05c)
• mcp7 (SPAC13A11.03)
• meu13 (SPAC222.15)
• mre11 (SPAC13C5.07)
• mst1 (SPAC637.12c)
• mto1 (SPCC417.07c)
• mus7 (SPAC6B12.02c)
• mus81 (SPCC4G3.05c)
• nbs1 (SPBC6B1.09c)
• nse1 (SPCC550.05)
• rad16 (SPCC970.01)
• rad17 (SPAC14C4.13)
• rad50 (SPAC1556.01c)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rad54 (SPAC15A10.03c)
• rad55 (SPAC3C7.03c)
• rad57 (SPAC20H4.07)
• rec10 (SPAC25G10.04c)
• rqh1 (SPAC2G11.12)
• sfr1 (SPBC28F2.07)
• ste20 (SPBC12C2.02c)
• swi5 (SPBC409.03)
• tor1 (SPBC30D10.10c)

Genotypes:

• cdc24-ts(C114R aa)
• cdc27-D1(160-372 Δaa)
• dmc1delta
• dna2-L1097S(aa)
• exo1delta
• gad8delta
• kms1delta
• lig4delta
• loh4-1(E344K reported but E is 343 or 345)
• mcp7delta
• meu13delta
• mre11delta
• mst1-L344S(aa)
• mto1delta
• mus7delta
• mus81delta
• nbs1delta
• nse1-1(unknown)
• rad16delta
• rad17delta
• rad50delta
• rad51delta
• rad52-R45K(aa)
• rad52delta
• rad54-KA(K300A aa)
• rad54-KR(K300R aa)
• rad54delta
• rad55delta
• rad57delta
• rec10delta
• rqh1delta
• sfr1delta
• ste20delta
• swi5-39(Q38*)
• swi5delta
• tor1delta

FYPO:0003081 - decreased genetic imprinting at mating-type locus

References:

• PMID:23260662
• PMID:26201080

Genes:

• lsd1 (SPBC146.09c)
• mrc1 (SPAC694.06c)

Genotypes:

• lsd1-E918(E918*)
• lsd1-W891A(aa)
• mrc1-A700T(aa)
• mrc1-K235E,K236E(aa)
• mrc1delta
• mrc1delta221-284(aa)

FYPO:0000470 - decreased mating type switching

References:

• PMID:12867036
• PMID:1475195
• PMID:15537537
• PMID:18388861
• PMID:19164572
• PMID:21211723
• PMID:22042869
• PMID:24189946
• PMID:24719968
• PMID:25203555
• PMID:2598273
• PMID:29852001
• PMID:30759238
• PMID:3481026
• PMID:6587363

Genes:

• adh4 (SPAC5H10.06c)
• afg1 (SPBC115.02c)
• alp13 (SPAC23H4.12)
• arp8 (SPAC664.02c)
• art1 (SPBC19G7.08c)
• asf1 (SPCC663.05c)
• atg24 (SPAC6F6.12)
• atg3 (SPBC3B9.06c)
• atp1 (SPAC14C4.14)
• atp16 (SPBC13E7.04)
• atp17 (SPBC1604.11)
• atp2 (SPAC222.12c)
• atp25 (SPAC31A2.06)
• atp4 (SPBC1604.07)
• atp5 (SPCC1840.06)
• atp7 (SPBC29A10.13)
• avt5 (SPBC1685.07c)
• bcs1 (SPAC644.07)
• brl2 (SPCC970.10c)
• bst1 (SPAC824.02)
• bud20 (SPAC19B12.11c)
• cbp1 (SPBC1105.04c)
• cbp3 (SPCC4B3.17)
• cbs2 (SPAC1556.08c)
• cdc23 (SPBC1347.10)
• cdt2 (SPAC17H9.19c)
• cgr1 (SPAC1556.05c)
• cho1 (SPBC337.16)
• cid16 (SPAC17H9.01)
• ckb1 (SPAC1851.03)
• clr1 (SPBC2D10.17)
• clr2 (SPAC1B3.17)
• clr3 (SPBC800.03)
• clr4 (SPBC428.08c)
• cnp3 (SPBC1861.01c)
• cnt5 (SPBC17G9.08c)
• cox5 (SPCC338.10c)
• cph1 (SPAC16C9.05)
• cph2 (SPAC2F7.07c)
• csm1 (SPAC11E3.03)
• cti1 (SPCC1739.07)
• cts2 (SPAPB1E7.04c)
• cwf12 (SPBC32F12.05c)
• cyp8 (SPAC21E11.05c)
• dbl7 (SPBC651.12c)
• dcn1 (SPBC839.03c)
• dcw1 (SPCC970.02)
• dis2 (SPBC776.02c)
• dni1 (SPAC31G5.07)
• dot2 (SPBC651.05c)
• dss1 (SPAC3G6.02)
• elp2 (SPCC895.06)
• elp3 (SPAC29A4.20)
• elp4 (SPCC11E10.06c)
• elp6 (SPBC3H7.10)
• eme1 (SPAPB1E7.06c)
• erd2 (SPBP8B7.22)
• erg4 (SPAC20G4.07c)
• erp5 (SPBC16E9.09c)
• fab1 (SPBC3E7.01)
• fim1 (SPBC1778.06c)
• fkh1 (SPBC839.17c)
• fkh2 (SPBC16G5.15c)
• fyv7 (SPAC8C9.07)
• gap1 (SPBC646.12c)
• gar2 (SPAC140.02)
• gcn3 (SPCC11E10.07c)
• grx3 (SPCC1450.06c)
• gsf1 (SPBC15D4.02)
• hip1 (SPBC31F10.13c)
• hip3 (SPBC31F10.14c)
• hip4 (SPBC947.08c)
• his7 (SPBC29A3.02c)
• hit1 (SPAC4F10.19c)
• hos2 (SPAC3G9.07c)
• hsr1 (SPAC3H1.11)
• hul5 (SPAC167.07c)
• hus5 (SPAC30D11.13)
• hva22 (SPBC30D10.09c)
• icp55 (SPAC12B10.05)
• ilv6 (SPBC14C8.04)
• img2 (SPAC3H8.03)
• inv2 (SPAC8E11.01c)
• lip2 (SPAC4F10.05c)
• lsg1 (SPCC4B3.08)
• lsk1 (SPAC2F3.15)
• ltv1 (SPAC3F10.17)
• mam4 (SPAC10F6.12c)
• map1 (SPAC11E3.06)
• mcm2 (SPBC4.04c)
• mcm4 (SPCC16A11.17)
• mcm6 (SPBC211.04c)
• med20 (SPAC17G8.05)
• met16 (SPAC13G7.06)
• meu17 (SPBC14C8.05c)
• mic19 (SPBC25H2.09)
• mim1 (SPBC713.08)
• mmp1 (SPBC2D10.07c)
• mms1 (SPAC3H8.05c)
• mpn1 (SPAC23C11.10)
• mrc1 (SPAC694.06c)
• mre11 (SPAC13C5.07)
• mrh5 (SPBC25D12.06)
• msc1 (SPAC343.11c)
• msh2 (SPBC19G7.01c)
• msh3 (SPAC8F11.03)
• mtf2 (SPAC5D6.12)
• mug168 (SPBC660.09)
• mug58 (SPAC630.09c)
• nab2 (SPAC14C4.06c)
• nit1 (SPBC651.02)
• nop52 (SPBC9B6.07)
• nrm1 (SPBC16A3.07c)
• oxp1 (SPAC11D3.15)
• paf1 (SPAC664.03)
• par1 (SPCC188.02)
• pcf1 (SPBC29A10.03c)
• pdb1 (SPBC30D10.13c)
• pdc1 (SPAC20G4.08)
• pdi2 (SPAC17H9.14c)
• pfh1 (SPBC887.14c)
• php3 (SPAC23C11.08)
• php5 (SPBC3B8.02)
• pku80 (SPBC543.03c)
• pof3 (SPCC338.16)
• pol1 (SPAC3H5.06c)
• ppn1 (SPCC74.02c)
• psr1 (SPAC2F7.02c)
• puc1 (SPBC19F5.01c)
• pxd1 (SPCC1322.02)
• pxr1 (SPAC890.05)
• rad16 (SPCC970.01)
• rad52 (SPAC30D11.10)
• rad57 (SPAC20H4.07)
• raf1 (SPCC613.12c)
• rcf2 (SPAC1565.01)
• rea1 (SPAC227.17c)
• rec15 (SPBC1711.14)
• rgf1 (SPCC645.07)
• rgp1 (SPBC23E6.08)
• rgt1 (SPCC320.03)
• rho3 (SPAC23C4.08)
• ric1 (SPAC1851.04c)
• rik1 (SPCC11E10.08)
• rpl1101 (SPAC26A3.07c)
• rpl1201 (SPCC16C4.13c)
• rpl1601 (SPBC839.13c)
• rpl1602 (SPAC23A1.11)
• rpl2002 (SPAC26A3.04)
• rpl2101 (SPBC365.03c)
• rpl2102 (SPAC959.08)
• rpl2401 (SPAC6G9.09c)
• rpl3001 (SPAC9G1.03c)
• rpl302 (SPAPB8E5.06c)
• rpl3601 (SPCC970.05)
• rpl3702 (SPCC1223.05c)
• rpl3703 (SPAPB17E12.05)
• rpl3801 (SPBC577.02)
• rpl39 (SPCC663.04)
• rpl4301 (SPBC800.04c)
• rpl501 (SPAC3H5.12c)
• rpl502 (SPBC11C11.09c)
• rpl702 (SPAC3H5.07)
• rpl801 (SPAC1F7.13c)
• rpl902 (SPCC613.06)
• rpp101 (SPAC644.15)
• rpp102 (SPBC3B9.13c)
• rps002 (SPAPJ698.02c)
• rps1002 (SPBP22H7.08)
• rps1202 (SPBC1685.02c)
• rps2201 (SPAC22A12.04c)
• rps23 (SPAC23C11.02c)
• rps2801 (SPAC25G10.06)
• rps602 (SPAPB1E7.12)
• rps901 (SPAC24H6.07)
• rqt3 (SPCC1906.02c)
• rrp14 (SPAC8C9.10c)
• rrp17 (SPAC29A4.09)
• rsn1 (SPBC354.08c)
• rxt3 (SPCC1259.07)
• sbh1 (SPBC2G2.03c)
• sco1 (SPBC119.06)
• sdh1 (SPAC1556.02c)
• sds23 (SPBC646.13)
• sec71 (SPAC4D7.01c)
• sep1 (SPBC4C3.12)
• set2 (SPAC29B12.02c)
• sgo1 (SPBP35G2.03c)
• sim3 (SPBC577.15c)
• sir2 (SPBC16D10.07c)
• slm9 (SPBC15D4.03)
• spe1 (SPAC144.04c)
• spe2 (SPBP4H10.05c)
• spf1 (SPCC594.05c)
• spp1 (SPAC6B12.10c)
• spp2 (SPBC17D11.06)
• spt4 (SPBC21C3.16c)
• spt6 (SPAC1F7.01c)
• srb10 (SPAC23H4.17c)
• srm1 (SPBC12C2.07c)
• ssp1 (SPCC297.03)
• swd1 (SPAC23H3.05c)
• swd2 (SPBC18H10.06c)
• swi1 (SPBC216.06c)
• swi10 (SPBC4F6.15c)
• swi2 (SPAC1142.03c)
• swi3 (SPBC30D10.04)
• swi5 (SPBC409.03)
• swi6 (SPAC664.01c)
• sxa1 (SPAC26A3.01)
• tdh1 (SPBC32F12.11)
• tea2 (SPBC1604.20c)
• tma23 (SPAC1952.02)
• tor1 (SPBC30D10.10c)
• trm140 (SPBC21C3.07c)
• trm5 (SPAPB18E9.01)
• trm734 (SPBC1306.02)
• tsr401 (SPBC25H2.15)
• tsr402 (SPAC13G6.09)
• ubc12 (SPCC777.10c)
• ubi1 (SPAC11G7.04)
• ubi4 (SPBC337.08c)
• ubp14 (SPBC6B1.06c)
• ubr1 (SPBC19C7.02)
• ubx3 (SPAC343.09)
• ufd2 (SPAC20H4.10)
• vsl1 (SPCC594.06c)
• whi5 (SPBC800.02)
• wis1 (SPBC409.07c)
• yhm2 (SPBC83.13)
• zfs1 (SPBC1718.07c)
• zuo1 (SPBC1778.01c)
• SPAC11D3.10
• SPAC1786.04
• SPAC22E12.18
• SPAC23C11.06c
• SPAC23C4.09c
• SPAC25G10.01
• SPAC26H5.09c
• SPAC6C3.03c
• SPAPB24D3.08c
• SPAPJ695.01c
• SPBC16A3.02c
• SPBC16H5.08c
• SPBC428.15

Genotypes:

• SPAC11D3.10delta
• SPAC1786.04delta
• SPAC22E12.18delta
• SPAC23C11.06cdelta
• SPAC23C4.09cdelta
• SPAC25G10.01delta
• SPAC26H5.09cdelta
• SPAC6C3.03cdelta
• SPAPB24D3.08cdelta
• SPAPJ695.01cdelta
• SPBC16A3.02cdelta
• SPBC16H5.08cdelta
• SPBC428.15delta
• adh4delta
• afg1delta
• alp13delta
• arp8delta
• art1delta
• asf1-1(C30F,D54N aa)
• atg24delta
• atg3delta
• atp16delta
• atp17delta
• atp1delta
• atp25delta
• atp2delta
• atp4delta
• atp5delta
• atp7delta
• avt5delta
• bcs1delta
• brl2delta
• bst1delta
• bud20delta
• cbp1delta
• cbp3delta
• cbs2delta
• cdc19-P1(P257L,T272I aa)
• cdc21-M68(unknown)
• cdc23-1E2(C239Y aa)
• cdc23-M30(T560C nt)
• cdc23-M36(D232G,V265I aa)
• cdt2delta
• cgr1delta
• cho1delta
• cid16delta
• ckb1delta
• clr1delta
• clr2delta
• clr3delta
• clr4delta
• cnp3delta
• cnt5delta
• cox5delta
• cph1delta
• cph2delta
• csm1delta
• cti1delta
• cts2delta
• cwf12delta
• cyp8delta
• dbl7delta
• dcn1delta
• dcw1delta
• dis2delta
• dni1delta
• dot2delta
• dss1delta
• elp2delta
• elp3delta
• elp4delta
• elp6delta
• eme1delta
• erd2delta
• erg4delta
• erp5delta
• fab1delta
• fim1delta
• fkh1delta
• fkh2delta
• fyv7delta
• gap1delta
• gar2delta
• gcn3delta
• grx3delta
• gsf1delta
• hip1delta
• hip3delta
• hip4delta
• his7delta
• hit1delta
• hos2delta
• hsr1delta
• hul5delta
• hus5delta
• hva22delta
• icp55delta
• ilv6delta
• img2delta
• inv2delta
• lip2delta
• lsg1delta
• lsk1delta
• ltv1delta
• mam4delta
• map1delta
• med20delta
• met16delta
• meu17delta
• mic19delta
• mim1delta
• mis5-268(unknown)
• mmp1delta
• mms1delta
• mpn1delta
• mrc1delta
• mre11delta
• mrh5delta
• msc1delta
• msh2delta
• msh3delta
• mtf2delta
• mug168delta
• mug58delta
• nab2delta
• nit1delta
• nop52delta
• nrm1delta
• oxp1delta
• paf1delta
• par1delta
• pcf1delta
• pdb1delta
• pdc1delta
• pdi2delta
• pfh1delta
• php3delta
• php5delta
• pku80delta
• pof3delta
• ppn1delta
• psr1delta
• puc1delta
• pxd1delta
• pxd1delta108-226(aa)
• pxr1delta
• rad16delta
• rad22-(unknown)
• rad57delta
• raf1delta
• rcf2delta
• rea1delta
• rec15delta
• rgf1delta
• rgp1delta
• rgt1delta
• rho3delta
• ric1delta
• rik1delta
• rpl1101delta
• rpl1201delta
• rpl1601delta
• rpl1602delta
• rpl2002delta
• rpl2101delta
• rpl2102delta
• rpl2401delta
• rpl3001delta
• rpl302delta
• rpl3601delta
• rpl3702delta
• rpl3703delta
• rpl3801delta
• rpl39delta
• rpl4301delta
• rpl501delta
• rpl502delta
• rpl702delta
• rpl801delta
• rpl902delta
• rpp101delta
• rpp102delta
• rps002delta
• rps1002delta
• rps1202delta
• rps2201delta
• rps23delta
• rps2801delta
• rps602delta
• rps901delta
• rqt3delta
• rrp14delta
• rrp17delta
• rsn1delta
• rxt3delta
• sbh1delta
• sco1delta
• sdh1delta
• sds23delta
• sec71delta
• sep1delta
• set2delta
• sgo1delta
• sim3delta
• sir2delta
• slm9delta
• spe1delta
• spe2delta
• spf1delta
• spp1-14(unknown)
• spp1-4(unknown)
• spp2-8(unknown)
• spt4delta
• spt6delta
• srb10delta
• srm1delta
• ssp1delta
• swd1delta
• swd2delta
• swi1-(unknown)
• swi1-1(disruption)
• swi1-111(unknown)
• swi10-(unknown)
• swi10::ura4+[Null]
• swi10delta
• swi2-(unknown)
• swi2delta
• swi3-(unknown)
• swi3-1(unknown)
• swi3-146(unknown)
• swi3-157(unknown)
• swi3delta
• swi4-(unknown)
• swi5-(unknown)
• swi5delta
• swi6-(unknown)
• swi6-115(W269R aa)
• swi6delta
• swi7-(unknown)
• swi7-1(G1116E aa)
• swi8-(unknown)
• swi9-(unknown)
• sxa1delta
• tdh1delta
• tea2delta
• tma23delta
• tor1delta
• trm140delta
• trm5delta
• trm734delta
• tsr401delta
• tsr402delta
• ubc12delta
• ubi1delta
• ubi4delta
• ubp14delta
• ubr1delta
• ubx3delta
• ufd2delta
• vsl1delta
• whi5delta
• wis1delta
• yhm2delta
• zfs1delta
• zuo1delta

FYPO:0003286 - decreased mitotic chromosome condensation

References:

• PMID:10756203
• PMID:11554922
• PMID:11861551
• PMID:23263988
• PMID:26869222
• PMID:28545058
• PMID:7957061
• PMID:8769419

Genes:

• ark1 (SPCC320.13c)
• bir1 (SPCC962.02c)
• cdc20 (SPBC25H2.13c)
• cnd1 (SPBC776.13)
• cnd2 (SPCC306.03c)
• cnd3 (SPCC188.03)
• cut14 (SPBP4H10.06c)
• cut3 (SPBC146.03c)
• fas2 (SPAC4A8.11c)
• fbh1 (SPBC336.01)
• hrp1 (SPAC1783.05)
• rae1 (SPBC16A3.05c)
• top2 (SPBC1A4.03c)

Genotypes:

• ark1-as3(L166A,S229A,Q28R,Q176R aa)
• bir1-1(T194A aa)
• cnd1-ae7(D368N aa)
• cnd2-ae9(L103P aa)
• cnd2-s1(S85F aa)
• cnd3-j29(R205Q aa)
• cut14-208(S861P aa)
• cut14-aa14(T558L aa)
• cut14-r8(G10D aa)
• cut17-275(A990T aa)
• cut3-477(S1147P aa)[Knockdown]
• cut3-477(S1147P aa)
• cut3-l23(S1116P aa)
• cut3-m26(L289F aa)
• fas2-H518(I600N aa)
• fbh1-c18(D734N aa)
• fbh1delta
• hrp1+(wild type)[Overexpression]
• pol2-am7(S400F aa)
• rae1-167(unknown)
• top2-191(unknown)

FYPO:0006860 - decreased mitotic DNA replication at rDNA

References:

• PMID:30796050

Genes:

• ssu72 (SPAC3G9.04)

Genotypes:

• ssu72delta

FYPO:0006859 - decreased mitotic DNA replication at telomere

References:

• PMID:30796050

Genes:

• ssu72 (SPAC3G9.04)

Genotypes:

• ssu72delta

FYPO:0004475 - decreased mitotic DNA replication initiation

References:

• PMID:9605404

Genes:

• cdc20 (SPBC25H2.13c)

Genotypes:

• cdc20-P7(unknown)

FYPO:0000482 - decreased mitotic recombination

References:

• PMID:11104907
• PMID:15336631
• PMID:18231579
• PMID:25533340
• PMID:39789818

Genes:

• csk1 (SPAC1D4.06c)
• dsk1 (SPBC530.14c)
• rad52 (SPAC30D11.10)
• rlp1 (SPBC1685.11)
• xlf1 (SPCC24B10.14c)

Genotypes:

• csk1delta
• dsk1delta
• rad52delta
• rlp1delta
• xlf1.AA(T180A,S192A aa)

FYPO:0006281 - decreased mitotic recombination at centromere

References:

• PMID:28977643

Genes:

• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rad54 (SPAC15A10.03c)

Genotypes:

• rad51delta
• rad52delta
• rad54delta

FYPO:0006282 - decreased mitotic recombination at chromosome arms

References:

• PMID:28977643
• PMID:41330900

Genes:

• pmt3 (SPBC365.06)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rad54 (SPAC15A10.03c)

Genotypes:

• pmt3-KallR(K14R,K30R,K39R,K51R,K53R,K54R,K60R,K63R,K71R aa)
• rad51delta
• rad52delta
• rad54delta

FYPO:0005431 - decreased mitotic recombination at hotspot

References:

• PMID:12019258

Genes:

• mre11 (SPAC13C5.07)
• rad50 (SPAC1556.01c)

Genotypes:

• mre11-D25A(aa)
• rad50S(K81I aa)
• rad50delta

FYPO:0008332 - decreased mRNA poly(A) tail uridylation

References:

• PMID:39333464

Genes:

• cid1 (SPAC19D5.03)

Genotypes:

• cid1delta

FYPO:0003175 - decreased nucleotide-excision repair during cellular response to UV

References:

• PMID:8846774

Genes:

• rad13 (SPBC3E7.08c)

Genotypes:

• rad13delta

FYPO:0002833 - decreased polyuridylation-dependent decapping of nuclear-transcribed mRNA

References:

• PMID:19430462

Genes:

• lsm1 (SPBC3D6.08c)

Genotypes:

• lsm1delta

FYPO:0001982 - decreased rate of DNA replication during vegetative growth

References:

• PMID:12871901
• PMID:18093330
• PMID:6943408
• PMID:8887553

Genes:

• cdc1 (SPAC27E2.05)
• cdc23 (SPBC1347.10)
• cdc27 (SPBC1734.02c)
• cds1 (SPCC18B5.11c)
• cdt2 (SPAC17H9.19c)
• mcm4 (SPCC16A11.17)
• rad3 (SPBC216.05)

Genotypes:

• cdc1delta
• cdc21-M68(unknown)
• cdc23-M36(D232G,V265I aa)
• cdc27-delta37-372(aa)
• cds1delta
• cdt2-M1(R50*)
• rad3delta

FYPO:0003923 - decreased rate of mitotic DNA replication elongation

References:

• PMID:21518960
• PMID:22718908
• PMID:28481910
• PMID:28806726
• PMID:34108240
• PMID:34228709

Genes:

• cdc20 (SPBC25H2.13c)
• cdc45 (SPAC17D4.02)
• cds1 (SPCC18B5.11c)
• mrc1 (SPAC694.06c)
• pcn1 (SPBC16D10.09)

Genotypes:

• cdc20-P287R(aa)
• cdc20-ct1(Y1520N,D1625G,L1726S,S1904P aa)
• cdc45-3A(S275A,S322A,S397A aa)
• cdc45-3D(S275D,S322D,S397D aa)
• cds1delta
• mrc1delta
• pcn1-K164R(aa)

FYPO:0003925 - decreased rate of mitotic DNA replication elongation at highly transcribed RNA polymerase II genes

References:

• PMID:22426534

Genes:

• pfh1 (SPBC887.14c)

Genotypes:

• pfh1+(wild type)[Knockdown]

FYPO:0006240 - decreased rate of mitotic DNA replication elongation during cellular response to DNA damage

References:

• PMID:28806726

Genes:

• cds1 (SPCC18B5.11c)

Genotypes:

• cds1delta

FYPO:0006603 - decreased replication fork arrest at RTS1 barrier

References:

• PMID:11030618
• PMID:26201080
• PMID:37615341

Genes:

• mrc1 (SPAC694.06c)
• rtf1 (SPAC22F8.07c)
• rtf2 (SPAC1D4.09c)
• swi1 (SPBC216.06c)
• swi3 (SPBC30D10.04)

Genotypes:

• mrc1delta
• rtf1-intron2NE(K202KVWSLACCFIINIKKQ)
• rtf2delta
• swi1-111(unknown)
• swi1-E662K(aa)
• swi3-146(unknown)

FYPO:0006604 - decreased replication fork arrest at tRNA locus

References:

• PMID:26201080

Genes:

• mrc1 (SPAC694.06c)

Genotypes:

• mrc1delta

FYPO:0007532 - decreased replication fork colocalization with nuclear pore complex

References:

• PMID:33159083
• PMID:38917328

Genes:

• alm1 (SPAC1486.04c)
• ctp1 (SPCC338.08)
• pku70 (SPCC126.02c)
• pli1 (SPAC1687.05)
• pmt3 (SPBC365.06)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rfp1 (SPAC19A8.10)
• rfp2 (SPAC343.18)
• slx8 (SPBC3D6.11c)

Genotypes:

• alm1delta
• ctp1delta
• pku70delta
• pli1delta
• pmt3+(wild type)[Knockdown]
• pmt3-D81R(aa)
• pmt3-KallR(K14R,K30R,K39R,K51R,K53R,K54R,K60R,K63R,K71R aa)
• pmt3delta
• rad51-II3A(R152A,R324A,K334A aa)
• rad51delta
• rad52delta
• rfp1delta
• rfp2delta
• slx8-29(unknown)

FYPO:0007255 - decreased replication fork processing

References:

• PMID:30992049
• PMID:34108240
• PMID:34608864
• PMID:38917328

Genes:

• cdc45 (SPAC17D4.02)
• cds1 (SPCC18B5.11c)
• hhf2 (SPBC8D2.03c)
• hst4 (SPAC1783.04c)
• mst1 (SPAC637.12c)
• nup132 (SPAC1805.04)

Genotypes:

• cdc45-3A(S275A,S322A,S397A aa)
• cdc45-3D(S275D,S322D,S397D aa)
• cds1delta
• hhf2-KR(K6R,K9R,K13R,K17R aa)
• hst4-4SA(S354A,S355A,S362A,S363A aa)
• mst1-L344S(aa)
• nup132delta

FYPO:0006242 - decreased replication fork stalling during cellular response to DNA damage

References:

• PMID:28806726

Genes:

• cds1 (SPCC18B5.11c)

Genotypes:

• cds1delta

FYPO:0003589 - decreased replication slippage during replication fork processing

References:

• PMID:23093942
• PMID:28475874
• PMID:29215009
• PMID:33159083
• PMID:38917328

Genes:

• alm1 (SPAC1486.04c)
• ctp1 (SPCC338.08)
• exo1 (SPBC29A10.05)
• nup132 (SPAC1805.04)
• nup60 (SPCC285.13c)
• rad50 (SPAC1556.01c)
• rad51 (SPAC644.14c)
• rad52 (SPAC30D11.10)
• rpn10 (SPAC637.10c)
• slx8 (SPBC3D6.11c)

Genotypes:

• alm1delta
• ctp1delta
• exo1delta
• nup132delta
• nup60delta
• rad50delta
• rad51-II3A(R152A,R324A,K334A aa)
• rad51delta
• rad52delta
• rpn10delta
• slx8-29(unknown)

FYPO:0002137 - decreased RNA catabolic process during vegetative growth

References:

• PMID:12931193
• PMID:18042546
• PMID:19279143
• PMID:22907753
• PMID:25375137

Genes:

• arz1 (SPCC1494.03)
• dri1 (SPAC17H9.04c)
• nrd1 (SPAC2F7.11)
• pab2 (SPBC16E9.12c)
• pek1 (SPBC543.07)
• pmk1 (SPBC119.08)
• red1 (SPAC1006.03c)
• rpm1 (SPCC1322.01)
• scw1 (SPCC16C4.07)
• zfs1 (SPBC1718.07c)

Genotypes:

• arz1-B1(A1696C,A1700C nt)[Overexpression]
• arz1-B2(A1713C,A1717C nt)[Overexpression]
• arz1-MuB(A1696G,A1700G,A1713G,A1717G nt)[Overexpression]
• dri1delta
• nrd1+(wild type)[Overexpression]
• pab2delta
• pek1-DD(S234D,T238D aa)
• pmk1delta
• red1delta
• rpm1delta
• scw1delta
• zfs1delta

FYPO:0004009 - decreased rRNA transcription

References:

• PMID:12893961
• PMID:16816948
• PMID:2839305
• PMID:40132111
• PMID:41258116

Genes:

• cbp1 (SPBC1105.04c)
• pol5 (SPBC14C8.14c)
• rpa49 (SPAC2F3.03c)
• top2 (SPBC1A4.03c)
• tor1 (SPBC30D10.10c)

Genotypes:

• cbp1delta
• pol5+(wild type)[Knockdown]
• rpa51delta::ura4+(disruption)
• top2-191(unknown)
• tor1delta

FYPO:0005357 - decreased site-specific DNA replication termination at RTS1 barrier

References:

• PMID:12840005
• PMID:19416828

Genes:

• pmt3 (SPBC365.06)
• rtf2 (SPAC1D4.09c)

Genotypes:

• pmt3delta
• rtf2-1(Q146*)
• rtf2delta

FYPO:0006073 - decreased small RNA degradation

References:

• PMID:28541282

Genes:

• cid14 (SPAC12G12.13c)
• cid16 (SPAC17H9.01)

Genotypes:

• cid14delta
• cid16delta

FYPO:0003598 - decreased snRNA 3'-end processing

References:

• PMID:10445882

Genes:

• snu2 (SPSNRNA.02)

Genotypes:

• snu2-M4(CGCATGAAT213ATACTAGTC nt)
• snu2-M5(TTGACAAC222GGACTAGT nt)
• snu2-M6(ATTGGATGG230GACTAGTCC nt)

FYPO:0005786 - decreased spatial extent of double-strand break processing

References:

• PMID:21931565
• PMID:27729451

Genes:

• cdc24 (SPAC8F11.07c)
• dna2 (SPBC16D10.04c)
• exo1 (SPBC29A10.05)

Genotypes:

• cdc24-ts(C114R aa)
• dna2-L1097S(aa)
• exo1delta

FYPO:0006613 - decreased termination of RNA polymerase II transcription

References:

• PMID:11389847
• PMID:29899453
• PMID:31615333

Genes:

• cdk9 (SPBC32H8.10)
• cft1 (SPBC1709.08)
• ctf1 (SPBC3B9.11c)
• dhp1 (SPAC26A3.12c)
• dis3 (SPBC26H8.10)
• res2 (SPAC22F3.09c)
• rna14 (SPAC6F12.17)

Genotypes:

• cdk9-T120G(aa)
• cft1-665(unknown)
• ctf1-Tyr260Stop(Y260*)
• dhp1+(wild type)[Knockdown]
• dis3-54(P509L aa)
• res2delta
• rna14+(wild type)[Knockdown]
• rna14-393(L271P aa)

FYPO:0002894 - decreased transcription during cellular response to calcium ion

References:

• PMID:20018864
• PMID:22496451

Genes:

• msn5 (SPAC328.01c)
• ncs1 (SPAC18B11.04)
• pac1 (SPBC119.11c)
• pka1 (SPBC106.10)
• prz1 (SPAC4G8.13c)
• rad24 (SPAC8E11.02c)
• rad25 (SPAC17A2.13c)
• tfs1 (SPAC20H4.03c)

Genotypes:

• msn5::ura4+[Null]
• ncs1-mec1-promoter-delta((-130)-(-102))
• pac1-A324T(unknown)
• pka1+(wild type)[Overexpression]
• pka1delta
• prz1delta
• rad24+(wild type)[Overexpression]
• rad25+(wild type)[Overexpression]
• tfs1delta

FYPO:0006676 - decreased transcription during cellular response to hydroxyurea

References:

• PMID:11781565

Genes:

• cig2 (SPAPB2B4.03)

Genotypes:

• cig2delta-147--44((-147)-(-44))

FYPO:0001852 - decreased transcription during iron starvation

References:

• PMID:19915076
• PMID:25733668
• PMID:8321236

Genes:

• abc3 (SPBC359.05)
• frp1 (SPBC1683.09c)
• shu1 (SPAC1F8.02c)

Genotypes:

• abc3-M1,M2(T(-202)G,T(-201)A,A(-200)C,T(-199)G,C(-198)G,A(-197)C,T(-120)C,G(-119)C,A(-118)T,T(-117)G,A(-116)T,T(-115)C)
• abc3-M1(T(-202)G,T(-201)A,A(-200)C,T(-199)G,C(-198)G,A(-197)C)
• abc3-M2(T(-120)C,G(-119)C,A(-118)T,T(-117)G,A(-116)T,T(-115)C)
• abc3-promoter-delta((-239)-(-114))
• frp1(-67--138)((-138)-(-67))
• shu1-M1-GATA-box-mutant(-127AGATA-122,-136AGATAA-131,-136TGATAA-141GCCGTC)[Overexpression]

FYPO:0006544 - decreased transcription during mitosis

References:

• PMID:9755169

Genes:

• cdc10 (SPBC336.12c)

Genotypes:

• cdc10-129(T429A aa)

FYPO:0000781 - decreased transcription during vegetative growth

References:

• PMID:11781565
• PMID:1849107
• PMID:18849471
• PMID:22226946
• PMID:24224056
• PMID:24493644
• PMID:27227887
• PMID:27902423
• PMID:31748520
• PMID:34686329
• PMID:8163491

Genes:

• atf1 (SPBC29B5.01)
• cgs1 (SPAC8C9.03)
• cig2 (SPAPB2B4.03)
• gtr2 (SPCC777.05)
• lam2 (SPBC1778.05c)
• pcr1 (SPAC21E11.03c)
• rps2501 (SPBC3D6.15)
• rrp6 (SPAC1F3.01)
• spt20 (SPAC4D7.10c)
• thi1 (SPAC1486.10)
• tra1 (SPBP16F5.03c)
• tra2 (SPAC1F5.11c)
• trx2 (SPBC12D12.07c)
• trz2 (SPBC3D6.03c)
• ubr11 (SPAC15A10.11)

Genotypes:

• atf1delta
• cgs1-1(unknown)
• cig2delta-147--44((-147)-(-44))
• gtr2delta
• lam2delta
• pcr1delta
• rps2501(promoter-45--38)((-45)-(-38))
• rrp6delta
• spt20-HITd(290-300 Δaa)
• spt20delta
• thi1delta
• tra1-AA(W3660A,L3661A aa)
• tra1-Sptra2(Tra1 G2623-K2676 replaced by Tra2 H2564-K2617)
• tra1delta
• tra2-CKO(wild type)[Knockdown]
• trx2delta
• trz2(promoter-110--54)((-110)-(-54))
• ubr11delta

FYPO:0004452 - decreased transcription from CDRE promoter in response to calcium ion

References:

• PMID:25081204

Genes:

• cmk1 (SPACUNK12.02c)

Genotypes:

• cmk1+(wild type)[Overexpression]

FYPO:0004480 - decreased transcription from CDRE promoter in response to micafungin

References:

• PMID:16928959

Genes:

• cch1 (SPAC6F6.01)
• mkh1 (SPAC1F3.02c)
• pck2 (SPBC12D12.04c)
• pek1 (SPBC543.07)
• pmk1 (SPBC119.08)
• yam8 (SPAC1F5.08c)

Genotypes:

• cch1delta
• mkh1delta
• pck2delta
• pek1delta
• pmk1delta
• yam8delta

FYPO:0004479 - decreased transcription from CDRE promoter in response to salt stress

References:

• PMID:16928959

Genes:

• cch1 (SPAC6F6.01)
• mkh1 (SPAC1F3.02c)
• pck2 (SPBC12D12.04c)
• pek1 (SPBC543.07)
• pmk1 (SPBC119.08)
• yam8 (SPAC1F5.08c)

Genotypes:

• cch1delta
• mkh1delta
• pck2delta
• pek1delta
• pmk1delta
• yam8delta

FYPO:0005496 - decreased transcription from CRE promoter

References:

• PMID:26108447

Genes:

• sty1 (SPAC24B11.06c)

Genotypes:

• sty1delta

FYPO:0005499 - decreased transcription from CRE promoter during cellular response to miconazole

References:

• PMID:26108447

Genes:

• sty1 (SPAC24B11.06c)

Genotypes:

• sty1delta

FYPO:0005318 - decreased transcription from MCB promoter

References:

• PMID:26890608
• PMID:30134042
• PMID:31260531

Genes:

• arp5 (SPBC365.10)
• arp8 (SPAC664.02c)
• caa1 (SPAC10F6.13c)
• cid14 (SPAC12G12.13c)
• elp1 (SPBC36.07)
• elp4 (SPCC11E10.06c)
• elp6 (SPBC3H7.10)
• eme1 (SPAPB1E7.06c)
• gcn5 (SPAC1952.05)
• hht2 (SPBC8D2.04)
• iec3 (SPCC1259.04)
• ies2 (SPAC6B12.05c)
• ies4 (SPAC23G3.04)
• ies6 (SPAC222.04c)
• kti12 (SPAC30.02c)
• mms19 (SPAC1071.02)
• mtq2 (SPAC323.05c)
• nht1 (SPAC10F6.08c)
• pht1 (SPBC11B10.10c)
• rep2 (SPBC2F12.11c)
• rpl1101 (SPAC26A3.07c)
• rpl2702 (SPCC74.05)
• rpl3703 (SPAPB17E12.05)
• rps2801 (SPAC25G10.06)
• ser2 (SPBC3H7.07c)
• trm112 (SPAC31A2.02)
• ubc14 (SPAC1250.03)

Genotypes:

• arp5delta
• arp8delta
• caa1delta
• cid14delta
• elp1delta
• elp4delta
• elp6delta
• eme1delta
• gcn5delta
• hht2-K9R,K18R(K10R,K19R aa)
• iec3delta
• ies2delta
• ies4delta
• ies6delta
• kti12delta
• mms19delta
• mtq2delta
• nht1delta
• pht1-4KR(K6R,K8R,K13R,K17R aa)
• rep2delta
• rpl1101delta
• rpl2702delta
• rpl3703delta
• rps2801delta
• ser2delta
• trm112delta
• ubc14delta

FYPO:0005229 - decreased transcription from RNA polymerase II promoter during vegetative growth

References:

• PMID:12359329
• PMID:17339332
• PMID:28366642

Genes:

• rct1 (SPBC17G9.05)
• spt5 (SPAC23C4.19)
• sua7 (SPAC16E8.16)

Genotypes:

• rct1+(wild type)/rct1delta
• spt5-degron[Knockdown]
• sua7+(wild type)[Knockdown]

FYPO:0003251 - decreased transcription from SRE promoter

References:

• PMID:16537923
• PMID:24327658
• PMID:32053662

Genes:

• hhp2 (SPAC23C4.12)
• ofd1 (SPBC6B1.08c)
• sre1 (SPBC19C2.09)
• ssp2 (SPCC74.03c)
• tom70 (SPAC6B12.12)

Genotypes:

• hhp2+(wild type)[Overexpression]
• ofd1+(wild type)[Overexpression]
• sre1delta
• ssp2delta
• tom70+(wild type)[Overexpression]

FYPO:0007613 - decreased transcription from STREP promoter

References:

• PMID:33400299

Genes:

• cgs1 (SPAC8C9.03)

Genotypes:

• cgs1delta

FYPO:0006473 - decreased transcription of amino acid biosynthesis genes in response to amino acid starvation

References:

• PMID:29432178

Genes:

• fil1 (SPCC1393.08)

Genotypes:

• fil1delta

FYPO:0003722 - decreased tRNA 5'-leader removal

References:

• PMID:3443299

Genes:

• rrk1 (SPNCRNA.128)

Genotypes:

• rrk1+(wild type)/rrk1::ura4+[Null]

FYPO:0006251 - decreased tRNA aminoacylation

References:

• PMID:28977649
• PMID:29330317

Genes:

• nrs1 (SPBC1773.10c)
• prs1 (SPBC19C7.06)
• sla1 (SPAC57A10.10c)

Genotypes:

• nrs1-hmt1(unknown)
• prs1-hmt2(unknown)
• sla1delta

FYPO:0007024 - decreased tRNA guanosine 7-methylation

References:

• PMID:25404562

Genes:

• trm7 (SPAC4F10.03c)
• trm734 (SPBC1306.02)

Genotypes:

• trm7+(wild type)[Knockdown]
• trm734delta

FYPO:0007025 - decreased tRNA guanosine N2-methylation

References:

• PMID:25404562

Genes:

• trm7 (SPAC4F10.03c)
• trm734 (SPBC1306.02)

Genotypes: