Phenotype ontology term - FYPO:0004318 - abolished mitotic spindle assembly checkpoint
Term summary
- ID
- FYPO:0004318
- Name
- abolished mitotic spindle assembly checkpoint
- Ontology or CV name
- Phenotype
- Definition
- A cell cycle checkpoint phenotype in which cell cycle regulation mediated by the mitotic cell cycle spindle assembly checkpoint does not occur under conditions that normally trigger the checkpoint signaling and response. Normally, the mitotic spindle assembly checkpoint delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
Annotation
Multi-locus phenotype
References:
Genes:
Genotypes:
- TetR-bub1-CD1(TetR-bub1-S381A,T383A,T386A) TetR-mps1
- TetR-bub1-TPR(TetR-bub1(1-240)) TetR-mps1
- TetR-bub1 TetR-mps1 mad1delta
- TetR-bub1 TetR-mps1 mad2delta
- TetR-bub1 TetR-mps1 mad3delta
- TetR-bub1N(TetR-bub1(aa1-325)) TetR-mps1
- alp5-1134(S402N aa) bub1delta
- alp5-1134(S402N aa) mad1delta
- alp5-1134(S402N aa) mad2delta
- alp5-1134(S402N aa) mad3delta
- apc14delta mad2+(wild type)[Overexpression] nda3-311(unknown)
- apc14delta mph1+(wild type)[Overexpression] nda3-311(unknown)
- apc15delta mad2delta nda3-311(unknown)
- apc15delta nda3-311(unknown)
- bub1-KD(K762R,D900N aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa)
- bub1-SATATA(S381A,T383A,T386A aa) mad1-KT-tethered(mad1-mis12 fusion)
- bub1-delta28-160(aa) nda3-KM311(G93E aa)
- bub3delta mad2delta
- bub3delta mph1-delta(1-302)(aa)
- bub3delta mph1delta
- bub3delta nda3-KM311(G93E aa)
- cdc11-119(unknown) cut7-446(I954T aa)
- cnp3C-mph1(cnp3C fusion)[Overexpression] spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- cut7-24(V968A aa) mad2delta
- cut7-24(V968A aa) mad3delta
- hhp2-K41R-7A(K41R,S307A,T309A,T329A,T345A,S358A,S368A,S381A aa) nda3-KM311(G93E aa)
- hta1-S121A(S122A aa) hta2-S121A(S122A aa)
- mad2delta mis6-302(G135E aa)
- mad2delta nda3-311(unknown)
- slp1+(wild type) slp1-mr63(A131P,F132T aa)
Single locus phenotype
References:
Genes:
Genotypes:
- TetR-spc7(1-666)-9TA(TetR-spc7Δ667-1364-T257A,T338A,T366A,T395A,T422A,T453A,T507A,T529A,T552A)
- alp14delta
- alp4-1891(unknown)
- atf1delta
- bub1-KD(K762R,D900N aa)
- bub1-SATATA(S381A,T383A,T386A aa)
- bub1delta
- bub3delta
- dma1delta
- mad1+(wild type)[Overexpression]
- mad1-1-526(527-676 Δaa)
- mad1-1-600(601-676 Δaa)
- mad1-4A(R510A,V511A,L512A,Q513A aa)
- mad1-564-676(1-563 Δaa)
- mad1-585-676(1-584 Δaa)
- mad1-RLK/AAA-KT-tethered(mis12-mad1-RLK-580-AAA)
- mad1-RLK/AAA(R580A,L581A,K582A aa)
- mad1-RLK/ALA(R580A,K582A aa)
- mad1-RL/AG(R510A,L512G aa)
- mad1delta
- mad2+(wild type)[Knockdown]
- mad2-R133A,Q134A(aa)
- mad2-R133A(aa)
- mad2-W74A(aa)
- mad2delta
- mad3-KEN1-AAA(K20A,E21A,N22A aa)
- mis6-302(G135E aa)
- mph1-delta(1-302)(aa)
- nda3-1828(unknown)
- ndc80-AK01(L246P aa)
- nuf2-1(unknown)
- nuf2delta
- rad21-45(I67T aa)
- sgo2delta
- sim4delta
- slp1-mr63(A131P,F132T aa)