Phenotype ontology term - FYPO:0004537 - mitotic spindle assembly checkpoint override

Term summary

ID

FYPO:0004537

Name

mitotic spindle assembly checkpoint override

Ontology or CV name

Phenotype

Definition

A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to mitotic cell cycle spindle assembly checkpoint signaling does not occur. As a result, the septation initiation network (SIN) signaling pathway is activated despite activation of the mitotic spindle assembly checkpoint (SAC). Normally, under conditions that activate the SAC, SIN activation is inhibited and the cell cycle arrests in anaphase. In this phenotype, premature SIN activation leads to premature cytokinesis and the formation of cut cells.

Parents

• has_output cut
• is_a abnormal response to mitotic cell cycle spindle assembly checkpoint signaling

Annotation