Phenotype ontology term - FYPO:0005780 - decreased response to mitotic spindle assembly checkpoint signaling
Term summary
- ID
- FYPO:0005780
- Name
- decreased response to mitotic spindle assembly checkpoint signaling
- Ontology or CV name
- Phenotype
- Definition
- A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to the mitotic spindle assembly checkpoint is decreased. The mitotic spindle assembly checkpoint normally delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions.
Annotation
Multi-locus phenotype
References:
Genes:
Genotypes:
- bub1-deltaGLEBS(264-299 Δaa) spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- bub1delta bub3delta spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- bub3delta spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- cnp3C-bub1(cnp3C fusion)[Overexpression] spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
- mph1delta spc7-12E(T77E,S221E,T257E,T338E,T366E,T395E,T413E,T422E,T453E,T507E,T529E,T552E aa)
Single locus phenotype
References:
Genes:
Genotypes:
- bub1-P*(T340A,T423A,T455A,S466A aa)
- bub1-deltaGLEBS(264-299 Δaa)
- bub1delta
- bub3delta
- cnp3C-bub1(cnp3C fusion)[Overexpression]
- mph1delta
- spc7-12E(T77E,S221E,T257E,T338E,T366E,T395E,T413E,T422E,T453E,T507E,T529E,T552E aa)
- spc7-12TA(T77A,S221A,T257A,T338A,T366A,T395A,T413A,T422A,T453A,T507A,T529A,T552A aa)
