GO cellular component ontology term - GO:0000176 - nuclear exosome (RNase complex)
Term summary
- ID
- GO:0000176
- Name
- nuclear exosome (RNase complex)
- Ontology or CV name
- GO cellular component
- Definition
- A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
