GO cellular component ontology term - GO:0000347 - THO complex
Term summary
- ID
- GO:0000347
- Name
- THO complex
- Ontology or CV name
- GO cellular component
- Definition
- The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
