GO molecular function ontology term - GO:0000703 - oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
Term summary
- ID
- GO:0000703
- Name
- oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
- Ontology or CV name
- GO molecular function
- Definition
- Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
