GO cellular component ontology term - GO:0000776 - kinetochore
Term summary
ID
GO:0000776
Name
kinetochore
Ontology or CV name
GO cellular component
Definition
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
Parents
is_a
intracellular membraneless organelle
is_a
supramolecular complex
part_of
condensed chromosome, centromeric region
Annotation
GO cellular component
GO:0000776
-
kinetochore
References:
GO_REF:0000033
GO_REF:0000111
PMID:11266451
PMID:11331883
PMID:11369198
PMID:11432827
PMID:11554922
PMID:11683390
PMID:11685532
PMID:11694582
PMID:11792803
PMID:11861551
PMID:11870212
PMID:11882285
PMID:11909965
PMID:11950879
PMID:11967147
PMID:12242294
PMID:12426374
PMID:14972679
PMID:15369671
PMID:15371542
PMID:15502821
PMID:15509783
PMID:15525536
PMID:15728720
PMID:15791413
PMID:15930132
PMID:16079914
PMID:16179942
PMID:16199877
PMID:16824200
PMID:16855399
PMID:16920624
PMID:17352737
PMID:18061564
PMID:18256284
PMID:18362178
PMID:18951025
PMID:19570910
PMID:19606211
PMID:19758558
PMID:20935472
PMID:21256022
PMID:21920317
PMID:22184248
PMID:22438582
PMID:22660415
PMID:22711988
PMID:23770679
PMID:25057016
PMID:25375240
PMID:26258632
PMID:28497540
PMID:34080538
PMID:36435910
PMID:36537249
PMID:9230309
Genes:
alp14 (SPCC895.07)
alp7 (SPAC890.02c)
ark1 (SPCC320.13c)
ask1 (SPBC27.02c)
bir1 (SPCC962.02c)
bub1 (SPCC1322.12c)
bub3 (SPAC23H3.08c)
cdc2 (SPBC11B10.09)
clp1 (SPAC1782.09c)
cnd1 (SPBC776.13)
cnp1 (SPBC1105.17)
cnp20 (SPBC800.13)
cnp3 (SPBC1861.01c)
csm1 (SPAC11E3.03)
cut14 (SPBP4H10.06c)
cut7 (SPAC25G10.07c)
dad2 (SPAC1805.07c)
dam1 (SPAC589.08c)
dis1 (SPCC736.14)
fta1 (SPAC4F10.12)
fta2 (SPAC1783.03)
fta3 (SPBP8B7.12c)
fta4 (SPCC1393.04)
fta6 (SPAC11H11.05c)
fta7 (SPCC1235.07)
hht1 (SPAC1834.04)
hht3 (SPBC1105.11c)
klp2 (SPAC664.10)
klp5 (SPBC2F12.13)
klp6 (SPBC1685.15c)
mad1 (SPBC3D6.04c)
mad2 (SPBC20F10.06)
mad3 (SPCC1795.01c)
mal2 (SPAC25B8.14)
mis12 (SPBC409.04c)
mis13 (SPBC409.09c)
mis14 (SPAC688.02c)
mis15 (SPBP22H7.09c)
mis16 (SPCC1672.10)
mis17 (SPBC21.01)
mis18 (SPCC970.12)
mis19 (SPBC27B12.02)
mis6 (SPAC1687.20c)
moa1 (SPAC15E1.07c)
mph1 (SPBC106.01)
nbl1 (SPBC725.12)
ndc80 (SPBC11C11.03)
nnf1 (SPAC29E6.04)
nuf2 (SPAC27F1.04c)
peg1 (SPAC3G9.12)
pic1 (SPBC336.15)
pkl1 (SPAC3A11.14c)
plo1 (SPAC23C11.16)
sgo1 (SPBP35G2.03c)
sgo2 (SPAC15A10.15)
slp1 (SPAC821.08c)
sos7 (SPAPB17E12.06)
spc24 (SPBC336.08)
spc25 (SPCC188.04c)
spc34 (SPAC8C9.17c)
spc7 (SPCC1020.02)
wip1 (SPAC17G8.15)
GO:0000776
-
kinetochore
References:
PMID:31615768
Genes:
peg1 (SPAC3G9.12)
GO:0042729
-
DASH complex
References:
PMID:16079914
PMID:17035632
Genes:
ask1 (SPBC27.02c)
dad1 (SPAC16A10.05c)
dad2 (SPAC1805.07c)
dad3 (SPAC14C4.16)
dad4 (SPBC3B9.22c)
dad5 (SPCC417.02)
dam1 (SPAC589.08c)
duo1 (SPBC32F12.08c)
spc19 (SPCC1223.15c)
spc34 (SPAC8C9.17c)
GO:0000939
-
inner kinetochore
References:
PMID:10398680
PMID:12719471
PMID:14972679
PMID:15908586
PMID:16541025
PMID:16855021
PMID:21920317
PMID:26275423
PMID:36705602
PMID:9230309
Genes:
ark1 (SPCC320.13c)
cnp20 (SPBC800.13)
fta2 (SPAC1783.03)
fta7 (SPCC1235.07)
mis12 (SPBC409.04c)
mis14 (SPAC688.02c)
mis6 (SPAC1687.20c)
par1 (SPCC188.02)
sgo1 (SPBP35G2.03c)
sim4 (SPBC18E5.03c)
GO:0180019
-
Knl1/Spc105 complex
References:
GO_REF:0000024
Genes:
sos7 (SPAPB17E12.06)
spc7 (SPCC1020.02)
GO:0000444
-
MIS12/MIND type complex
References:
GO_REF:0000033
PMID:15369671
PMID:29180432
Genes:
mis12 (SPBC409.04c)
mis13 (SPBC409.09c)
mis14 (SPAC688.02c)
nnf1 (SPAC29E6.04)
GO:0031511
-
Mis6-Sim4 complex
References:
PMID:12719471
PMID:16079914
PMID:21445296
Genes:
cnl2 (SPAC23H4.11c)
fta1 (SPAC4F10.12)
fta2 (SPAC1783.03)
fta3 (SPBP8B7.12c)
fta4 (SPCC1393.04)
fta6 (SPAC11H11.05c)
fta7 (SPCC1235.07)
mal2 (SPAC25B8.14)
mis15 (SPBP22H7.09c)
mis17 (SPBC21.01)
mis6 (SPAC1687.20c)
sim4 (SPBC18E5.03c)
GO:0033551
-
monopolin complex
References:
PMID:17627824
PMID:20935472
Genes:
csm1 (SPAC11E3.03)
mde4 (SPBC6B1.04)
GO:0031262
-
Ndc80 complex
References:
PMID:15728720
PMID:28502666
Genes:
ndc80 (SPBC11C11.03)
nuf2 (SPAC27F1.04c)
spc24 (SPBC336.08)
spc25 (SPCC188.04c)
GO:0000940
-
outer kinetochore
References:
GO_REF:0000024
PMID:11432827
PMID:11553715
PMID:14742702
PMID:16079915
PMID:22065639
PMID:36705602
Genes:
alp14 (SPCC895.07)
alp7 (SPAC890.02c)
bub1 (SPCC1322.12c)
dad1 (SPAC16A10.05c)
dam1 (SPAC589.08c)
mis12 (SPBC409.04c)
ndc80 (SPBC11C11.03)
nnf1 (SPAC29E6.04)
nsk1 (SPAC3G9.01)
spc25 (SPCC188.04c)
spc7 (SPCC1020.02)