GO molecular function ontology term - GO:0003714 - transcription corepressor activity
Term summary
- ID
- GO:0003714
- Name
- transcription corepressor activity
- Ontology or CV name
- GO molecular function
- Definition
- A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
