GO molecular function ontology term - GO:0004839 - ubiquitin activating enzyme activity
Term summary
- ID
- GO:0004839
- Name
- ubiquitin activating enzyme activity
- Ontology or CV name
- GO molecular function
- Definition
- Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
