GO biological process ontology term - GO:0007094 - mitotic spindle assembly checkpoint signaling
Term summary
- ID
- GO:0007094
- Name
- mitotic spindle assembly checkpoint signaling
- Ontology or CV name
- GO biological process
- Definition
- A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC).
