GO biological process ontology term - GO:0007186 - G protein-coupled receptor signaling pathway
Term summary
- ID
- GO:0007186
- Name
- G protein-coupled receptor signaling pathway
- Ontology or CV name
- GO biological process
- Definition
- The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
