GO cellular component ontology term - GO:0030122 - AP-2 adaptor complex
Term summary
- ID
- GO:0030122
- Name
- AP-2 adaptor complex
- Ontology or CV name
- GO cellular component
- Definition
- A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
